Disease relevance of ISODRIN

• However, neither facial flushing nor testing the pupil reactions with pholedrine or hydroxyamphetamine can be relied on to predict the probable site of any lesion causing congenital Horner's syndrome [1].

High impact information on ISODRIN

• Inhibition of MAO by MP or its metabolites (amphetamine, p-hydroxyamphetamine and p-hydroxymethamphetamine) increased with the use of the following substrates in the order: DA, 5-HT, NE and beta-PEA [2].
• Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver [3].
• The aim of the study presented here was to identify the human hepatic cytochrome P450 (P450) enzymes involved in the biotransformation of PMMA to p-hydroxymethamphetamine [4].
• Promethin, a 15-kDa cytosolic protein, is not normally expressed in liver but induced robustly in liver with hepatic adiposis caused by PPARgamma overexpression [3].
• This paper describes a method for screening for and simultaneous quantification of the above-mentioned compounds and the metabolites p-hydroxyamphetamine and p-hydroxymethamphetamine (pholedrine) in human blood plasma [5].

Biological context of ISODRIN

• p-Hydroxymethamphetamine enantiomer pharmacokinetics and metabolism in rats: absence of N-demethylation [6].

Anatomical context of ISODRIN

• The major metabolite of MA in rat hepatocytes was p-hydroxymethamphetamine [7].
• The influence of lipophilic counter ions on the transport of the hydrophilic drugs pholedrine and bretylium across artificial lipid membranes has been studied using a permeation model system [8].
• Simultaneous quantitative analysis of methamphetamine and 4-hydroxymethamphetamine in body fluids by gas chromatography/mass spectrometry [9].

Associations of ISODRIN with other chemical compounds

• A simple, rapid and highly sensitive high-performance liquid chromatographic method with fluorescence detection for determining the enantiomers of methamphetamine and its major metabolites, amphetamine and p-hydroxymethamphetamine, in urine samples was developed [10].
• Direct determination of p-hydroxymethamphetamine glucuronide in human urine by high-performance liquid chromatography [11].
• Liquid chromatography, on the other hand, showed the urinary concentrations of p-hydroxymethamphetamine and p-hydroxyamphetamine for the ethanol-positive subjects to be lower than those for the ethanol-negative subjects in all three groups [12].

Gene context of ISODRIN

• The inhibition assay of enzyme-linked immunosorbent assay (ELISA) analysis using methamphetamine analogs indicated that NK-1 showed considerable reactivity not only MA-BSA but also methamphetamine and its major metabolite, para-hydroxymethamphetamine (p-hydroxymethamphetamine) [13].

Analytical, diagnostic and therapeutic context of ISODRIN

• Methamphetamine and 4-hydroxy-N-methylamphetamine were found to be non-reactive in the radioimmunoassay procedure [14].
• A sensitive and specific gas chromatography/mass spectrometry (GC/MS) method has been developed for the simultaneous analysis of methampthetamine and its metabolites (amphetamine, p-hydroxymethamphetamine, and p-hydroxyamphetamine) in monkey urine [15].
• Subcutaneous injection instead of oral administration of methamphetamine increased the urinary excretion of unchanged drug and amphetamine, and decreased the excretion of p-hydroxymethamphetamine [16].
• Fluorescence analysis of p-hydroxymethamphetamine in urine by thin-layer chromatography [17].

References