The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

ACMC-1BXT3     3-methyl-2-oxo-pentanoic acid

Synonyms: AG-D-90199, CHEBI:35932, HMDB00491, ANW-20983, AC1Q5BWY, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of alpha-keto-beta-methyl-valerate

 

High impact information on alpha-keto-beta-methyl-valerate

 

Biological context of alpha-keto-beta-methyl-valerate

  • An enzymatic method for the separate measurement of both chiral 2-oxo-3-methylvaleric acid (OMV) compounds, (S)- and (R)-OMV, by NADH-dependent enantioselective amination using leucine dehydrogenase in the presence of a NADH regenerating system is described [7].

References

  1. Mechanism of biosynthesis of 2-oxo-3-methylvalerate in Chlorobium vibrioforme. Nesbakken, T., Kolsaker, P., Ormerod, J. J. Bacteriol. (1988) [Pubmed]
  2. An improved assay for pyruvate dehydrogenase in liver and heart. Paxton, R., Sievert, L.M. Biochem. J. (1991) [Pubmed]
  3. Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. Coitinho, A.S., de Mello, C.F., Lima, T.T., de Bastiani, J., Fighera, M.R., Wajner, M. Brain Res. (2001) [Pubmed]
  4. Comparative metabolism and structure of BCKD-E2 in primary biliary cirrhosis. Turchany, J.M., Leung, P.S., Iwayama, T., Jefferson, D.M., Ishida, J., Yamaguchi, M., Munoz, S., Danner, D.J., Dickson, E.R., Gershwin, M.E. J. Autoimmun. (1993) [Pubmed]
  5. Effects of alpha-ketomonocarboxylic acids upon insulin secretion and metabolism of isolated pancreatic islets. Panten, U. Naunyn Schmiedebergs Arch. Pharmacol. (1975) [Pubmed]
  6. Alpha-keto-beta-methylvaleric acid increases the in vitro phosphorylation of intermediate filaments in cerebral cortex of young rats through the gabaergic system. Funchal, C., Dall Bello Pessutto, F., de Almeida, L.M., de Lima Pelaez, P., Loureiro, S.O., Vivian, L., Wajner, M., Pessoa-Pureur, R. J. Neurol. Sci. (2004) [Pubmed]
  7. Determination of (S)- and (R)-2-oxo-3-methylvaleric acid in plasma of patients with maple syrup urine disease. Wendel, U., Even, G., Langenbeck, U., Schadewaldt, P., Hummel, W. Clin. Chim. Acta (1992) [Pubmed]
 
WikiGenes - Universities