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Chemical Compound Review

Ketoleucine     4-methyl-2-oxo-pentanoic acid

Synonyms: oxoisocaproate, AGN-PC-00FS03, CHEMBL445647, AG-A-76821, ACMC-209pm0, ...
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Disease relevance of COI


Psychiatry related information on COI


High impact information on COI


Chemical compound and disease context of COI


Biological context of COI


Anatomical context of COI


Associations of COI with other chemical compounds


Gene context of COI


Analytical, diagnostic and therapeutic context of COI


  1. Evidence for valine intolerance in patients with cirrhosis. Schauder, P., Schröder, K., Herbertz, L., Langer, K., Langenbeck, U. Hepatology (1984) [Pubmed]
  2. Effect of experimental liver disease on the utilization for protein synthesis of orally administered alpha-ketoisocaproate. Muñoz, S., Walser, M. Hepatology (1986) [Pubmed]
  3. Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. Hoenig, M., Ferguson, D.C., Matschinsky, F.M. Diabetes (1984) [Pubmed]
  4. Inhibition, by 2-oxo acids that accumulate in maple-syrup-urine disease, of lactate, pyruvate, and 3-hydroxybutyrate transport across the blood-brain barrier. Cremer, J.E., Teal, H.M., Cunningham, V.J. J. Neurochem. (1982) [Pubmed]
  5. Chronic metabolic acidosis accelerates whole body proteolysis and oxidation in awake rats. May, R.C., Masud, T., Logue, B., Bailey, J., England, B. Kidney Int. (1992) [Pubmed]
  6. Nutritional and metabolic effects and significance of mild orotic aciduria during dietary supplementation with arginine or its organic salts after trauma injury in rats. Jeevanandam, M., Begay, C.K., Holaday, N.J., Petersen, S.R. Metab. Clin. Exp. (1997) [Pubmed]
  7. Utilization of alpha-ketoisocaproate for synthesis of hepatic export proteins and peripheral proteins in normal and cirrhotic subjects. Muñoz, S., Walser, M. Gastroenterology (1986) [Pubmed]
  8. Glucose-induced translocation of protein kinase C in rat pancreatic islets. Ganesan, S., Calle, R., Zawalich, K., Smallwood, J.I., Zawalich, W.S., Rasmussen, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  9. Mechanism of muscle wasting in myotonic dystrophy. Griggs, R.C., Jozefowicz, R., Kingston, W., Nair, K.S., Herr, B.E., Halliday, D. Ann. Neurol. (1990) [Pubmed]
  10. Assessment of mitochondrial function in vivo with a breath test utilizing alpha-ketoisocaproic acid. Michaletz, P.A., Cap, L., Alpert, E., Lauterburg, B.H. Hepatology (1989) [Pubmed]
  11. Alternative pathways for biosynthesis of leucine and other amino acids in Bacteroides ruminicola and Bacteroides fragilis. Allison, M.J., Baetz, A.L., Wiegel, J. Appl. Environ. Microbiol. (1984) [Pubmed]
  12. Hypobaric hypoxia affects endogenous levels of alpha-keto acids in murine heart ventricles. Mühling, J., Paddenberg, R., Hempelmann, G., Kummer, W. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Alpha-ketoisocaproic acid increases phosphorylation of intermediate filament proteins from rat cerebral cortex by mechanisms involving Ca2+ and cAMP. Funchal, C., Zamoner, A., dos Santos, A.Q., Loureiro, S.O., Wajner, M., Pessoa-Pureur, R. Neurochem. Res. (2005) [Pubmed]
  14. Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. van Someren, K.A., Edwards, A.J., Howatson, G. International journal of sport nutrition and exercise metabolism. (2005) [Pubmed]
  15. Glucose stimulation of beta-cell DNA replication in the intact rat and in pancreatic islets in suspension culture. Effects of alpha-ketoisocaproic acid, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine in the in vitro system. Logothetopoulos, J., Valiquette, N., Cvet, D. Diabetes (1983) [Pubmed]
  16. The mechanism of alpha-ketoisocaproate oxygenase. Formation of beta-hydroxyisovalerate from alpha-ketoisocaproate. Sabourin, P.J., Bieber, L.L. J. Biol. Chem. (1982) [Pubmed]
  17. pH regulation of mitochondrial branch chain alpha-keto acid transport and oxidation in rat heart mitochondria. Hutson, S.M. J. Biol. Chem. (1987) [Pubmed]
  18. Effects of branched chain alpha-ketoacids on the metabolism of isolated rat liver cells. I. Regulation of branched chain alpha-ketoacid metabolism. Williamson, J.R., Wałajtys-Rode, E., Coll, K.E. J. Biol. Chem. (1979) [Pubmed]
  19. Direct inhibition of the pancreatic beta-cell ATP-regulated potassium channel by alpha-ketoisocaproate. Bränström, R., Efendić, S., Berggren, P.O., Larsson, O. J. Biol. Chem. (1998) [Pubmed]
  20. Regulation of leucine and alpha-ketoisocaproic acid metabolism in skeletal muscle. Effects of starvation and insulin. Hutson, S.M., Zapalowski, C., Cree, T.C., Harper, A.E. J. Biol. Chem. (1980) [Pubmed]
  21. Alpha-ketoisocaproate is not a true substrate for ATP production by pancreatic beta-cell mitochondria. Lembert, N., Idahl, L.A. Diabetes (1998) [Pubmed]
  22. Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans. Ohta, M., Nelson, D., Nelson, J., Meglasson, M.D., Erecińska, M. J. Biol. Chem. (1990) [Pubmed]
  23. Studies on the regulation of the branched chain alpha-keto acid dehydrogenase in the perfused rat liver. Patel, T.B., DeBuysere, M.S., Barron, L.L., Olson, M.S. J. Biol. Chem. (1981) [Pubmed]
  24. A 13C nuclear magnetic resonance investigation of the metabolism of leucine to isoamyl alcohol in Saccharomyces cerevisiae. Dickinson, J.R., Lanterman, M.M., Danner, D.J., Pearson, B.M., Sanz, P., Harrison, S.J., Hewlins, M.J. J. Biol. Chem. (1997) [Pubmed]
  25. Regulation of alpha-ketoisocaproate oxidation in liver mitochondria by adenine nucleotides and calcium. Aftring, R.P., May, M.E., Manos, P.N., Buse, M.G. J. Biol. Chem. (1982) [Pubmed]
  26. Purification and characterization of an alpha-ketoisocaproate oxygenase of rat liver. Sabourin, P.J., Bieber, L.L. J. Biol. Chem. (1982) [Pubmed]
  27. Human Mitochondrial Branched Chain Aminotransferase Isozyme: STRUCTURAL ROLE OF THE CXXC CENTER IN CATALYSIS. Yennawar, N.H., Islam, M.M., Conway, M., Wallin, R., Hutson, S.M. J. Biol. Chem. (2006) [Pubmed]
  28. Somatostatin inhibits oxidative respiration in pancreatic beta-cells. Daunt, M., Dale, O., Smith, P.A. Endocrinology (2006) [Pubmed]
  29. Involvement of branched-chain amino acid aminotransferase (Bcat1/Eca39) in apoptosis. Eden, A., Benvenisty, N. FEBS Lett. (1999) [Pubmed]
  30. Pyruvate decarboxylase encoded by the PDC1 gene contributes, at least partially, to the decarboxylation of alpha-ketoisocaproate for isoamyl alcohol formation in Saccharomyces cerevisiae. Yoshimoto, H., Fukushige, T., Yonezawa, T., Sakai, Y., Okawa, K., Iwamatsu, A., Sone, H., Tamai, Y. J. Biosci. Bioeng. (2001) [Pubmed]
  31. Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells. Nakazaki, M., Kakei, M., Ishihara, H., Koriyama, N., Hashiguchi, H., Aso, K., Fukudome, M., Oka, Y., Yada, T., Tei, C. J. Physiol. (Lond.) (2002) [Pubmed]
  32. The C-terminal of rat 4-hydroxyphenylpyruvate dioxygenase is indispensable for enzyme activity. Lee, M.H., Zhang, Z.H., MacKinnon, C.H., Baldwin, J.E., Crouch, N.P. FEBS Lett. (1996) [Pubmed]
  33. 2-Oxoacids regulate kynurenic acid production in the rat brain: studies in vitro and in vivo. Hodgkins, P.S., Wu, H.Q., Zielke, H.R., Schwarcz, R. J. Neurochem. (1999) [Pubmed]
  34. Quantitation of endogenous analytes in biofluid without a true blank matrix. Li, W., Cohen, L.H. Anal. Chem. (2003) [Pubmed]
  35. Is a clinical application of hybrid liver support systems limited by an initial disorder in cellular amino acid and alpha-keto acid metabolism, rather than by later gradual loss of primary hepatocyte function? Gerlach, J.C., Fuchs, M., Smith, M.D., Bornemann, R., Encke, J., Neuhaus, P., Riedel, E. Transplantation (1996) [Pubmed]
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