The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Phenylbutyrate     4-phenylbutanoic acid

Synonyms: SureCN1716, NSC-295, AGN-PC-006I8K, AG-C-45091, ACMC-209eip, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC 295

  • 1-Aryl-3-(2-chloroethyl) ureas and 1-aryl-3-nitroso-3-(2-chloroethyl) ureas, derived from 4-phenylbutyric acid and alkylanilines, were synthesized and their cytotoxicity was evaluated on human adenocarcinoma cells in vitro [1].

High impact information on NSC 295


Biological context of NSC 295

  • In contrast, its enantiomer PD 140548 ((benzenebutanoic acid, beta-[[3-(1H-indol-3-yl)-2-methyl-1-oxo-2-[[(tricyclo[,7] dec-2-yloxy)carbonyl]amino]propyl] amino],-[S-(R*,S*)) displayed the reverse selectivity (CCKA IC50 = 2.8 nM, CCKB IC50 = 260 nM) [5].

Anatomical context of NSC 295


Associations of NSC 295 with other chemical compounds

  • The structural analysis of the isolated product by (1)H, (13)C NMR, mass spectroscopy and FT-IR revealed it to be a 4-phenyl butanoic acid derivative (CL) of lisinopril [6].
  • HPLC stability studies at pH 5.0 with the related model compounds 5, 7, 8, and 9, in which chlorambucil was substituted by 4-phenylbutyric acid, demonstrated that the carboxylic hydrazone derivatives have acid-sensitive properties; the acid lability of 7 was particular prominent with a half-life of only a few hours [7].

Gene context of NSC 295


Analytical, diagnostic and therapeutic context of NSC 295


  1. 1-Aryl-3-(2-chloroethyl) ureas: synthesis and in vitro assay as potential anticancer agents. Gaudreault, R.C., Lacroix, J., Pagé, M., Joly, L.P. Journal of pharmaceutical sciences. (1988) [Pubmed]
  2. Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Bonapace, G., Waheed, A., Shah, G.N., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Inhibition of Histone Deacetylation Does Not Block Resilencing of p16 after 5-Aza-2'-Deoxycytidine Treatment. Egger, G., Aparicio, A.M., Escobar, S.G., Jones, P.A. Cancer Res. (2007) [Pubmed]
  4. The peroxisome proliferator phenylbutyric acid (PBA) protects astrocytes from ts1 MoMuLV-induced oxidative cell death. Liu, N., Qiang, W., Kuang, X., Thuillier, P., Lynn, W.S., Wong, P.K. J. Neurovirol. (2002) [Pubmed]
  5. Peptoid CCK receptor antagonists: pharmacological evaluation of CCKA, CCKB and mixed CCKA/B receptor antagonists. Singh, L., Field, M.J., Hill, D.R., Horwell, D.C., McKnight, A.T., Roberts, E., Tang, K.W., Woodruff, G.N. Eur. J. Pharmacol. (1995) [Pubmed]
  6. Identification of a new impurity in lisinopril. Shinde, V., Trivedi, A., Upadhayay, P.R., Gupta, N.L., Kanase, D.G., Chikate, R. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  7. Albumin conjugates of the anticancer drug chlorambucil: synthesis, characterization, and in vitro efficacy. Kratz, F., Beyer, U., Roth, T., Schütte, M.T., Unold, A., Fiebig, H.H., Unger, C. Arch. Pharm. (Weinheim) (1998) [Pubmed]
  8. Antitumor drug-protein interactions. Binding of 1-beta-D-arabinofuranosyl cytosine to albumin and chemically modified albumin. Szekerke, M., Horváth, M., Hudecz, F. Arzneimittel-Forschung. (1979) [Pubmed]
  9. Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency. Burrows, J.A., Willis, L.K., Perlmutter, D.H. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
WikiGenes - Universities