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Chemical Compound Review:

Likviritin (2S)-7-hydroxy-2-[4- [(2S,3R,4S,5S,6R)-3,4...

Synonyms: Liquiritin, Liquiritoside, CHEMBL511995, Ambap551-15-5, AC1L9XRQ, ...

Li, K. et al., Li, L. et al., Okamura, N. et al., Ohtake, N. et al., Kawamori, T. et al., et al.

Ohtake, Suzuki, Daikuhara, Nakai, Yamamoto, Amagaya, Ishige, Sasaki, Komatsu, Fukuda, Hayashi, Okamura, Maki, Ishida, Uraguchi, Onishi, Sadasue, Tsuruta, Yagi,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AIDS166098

Previously, we showed that liquiritigenin (LQ), an aglycone of liquiritin in G. radix, exerts cytoprotective effects against heavy metal-induced toxicity in vitro [1].
Topical liquiritin improves melasma [2].

High impact information on AIDS166098

In groups of rats given AOM and liquiritin, oleanolic acid, or costunolide, the numbers of silver-stained nucleolar organizer regions/nucleus were significantly lower than that of AOM alone (P < 0.05, P < 0.01, and P < 0.05, respectively) [3].
In this study, we report the development of a liquid chromatography tandem mass spectrometry (LC-MS/MS)-based method capable of simultaneously quantifying multiple active licorice flavonoids (including liquiritin apioside, liquiritin, liquiritigenin, isoliquiritin apioside, isoliquiritin, and isoliquiritigenin) in plasma [4].
Liquiritigenin, a metabolite of liquiritin which is one of the major ingredients in SST enhanced in vitro IL-6 production in anti-CD3 monoclonal antibody (anti-CD3 mAb)-stimulated lung mononuclear cells in a cell-type specific and dose-dependent manner [5].
We describe here a method using HPLC for the simultaneous determination of albiflorin, paeoniflorin, glycyrrhizin and six flavanone glycosides (liquiritin, liquiritin apioside, naringin, neohesperidin, hesperidin and narirutin) in the Kampo medicines, Shigyaku-san and Haino-san [6].
High-performance liquid chromatography was employed to determine the contents of the eight marker components liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid [7].

Associations of AIDS166098 with other chemical compounds

Determination of Liquiritin, Naringin, Hesperidin, Thymol, Imperatorin, Honokiol, Isoimperatorin, and Magnolol in the Traditional Chinese Medicinal Preparation Huoxiang-zhengqi Liquid Using High-performance Liquid Chromatography [7].

References

Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine. Kim, Y.W., Ki, S.H., Lee, J.R., Lee, S.J., Kim, C.W., Kim, S.C., Kim, S.G. Chem. Biol. Interact. (2006) [Pubmed]
Topical liquiritin improves melasma. Amer, M., Metwalli, M. International journal of dermatology. (2000) [Pubmed]
Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. Kawamori, T., Tanaka, T., Hara, A., Yamahara, J., Mori, H. Cancer Res. (1995) [Pubmed]
Simultaneous quantification of multiple licorice flavonoids in rat plasma. Li, L., Liang, S., Du, F., Li, C. J. Am. Soc. Mass Spectrom. (2007) [Pubmed]
Modulation of lung local immune responses by oral administration of a herbal medicine Sho-saiko-to. Ohtake, N., Suzuki, R., Daikuhara, H., Nakai, Y., Yamamoto, M., Amagaya, S., Ishige, A., Sasaki, H., Komatsu, Y., Fukuda, K., Hayashi, S. Int. J. Immunopharmacol. (2000) [Pubmed]
Dissolution profiles of principal ingredients in Kampo medicinal powders by high-performance liquid chromatography. Okamura, N., Maki, T., Ishida, S., Uraguchi, C., Onishi, Y., Sadasue, E., Tsuruta, Y., Yagi, A. Chem. Pharm. Bull. (2000) [Pubmed]
Determination of Liquiritin, Naringin, Hesperidin, Thymol, Imperatorin, Honokiol, Isoimperatorin, and Magnolol in the Traditional Chinese Medicinal Preparation Huoxiang-zhengqi Liquid Using High-performance Liquid Chromatography. Li, K., Yuan, J., Su, W. Yakugaku Zasshi (2006) [Pubmed]

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