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Chemical Compound Review

Magnolol     2-(2-hydroxy-5-prop-2-enyl- phenyl)-4-prop...

Synonyms: UPCMLD-DP037, PubChem19035, S2321_Selleck, CHEMBL180920, SureCN132477, ...
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Disease relevance of Magnolol


High impact information on Magnolol


Chemical compound and disease context of Magnolol


Biological context of Magnolol

  • Overexpression of Bcl-2 protected CH27 cells against magnolol-triggered apoptosis [2].
  • Previously, we showed that magnolol induces cell-cycle arrest in cultured colon and liver cancer cells through an upregulation of the p21 protein [1] [3].
  • Major components from the cortex of Magnoliae (magnolol and honokiol), which have anti-inflammatory and anti-bacterial actions, inhibited the acetyltransferase activity in rat spleen microsomes (IC50, 150 and 150 microM, respectively) and membrane fractions of human PMNs (IC50, 70 and 60 microM, respectively) [12].
  • Pretreatment with z-VAD-fmk markedly inhibited magnolol-induced cell death, but did not prevent cytosolic cytochrome c accumulation [2].
  • Gel shift assays using the (32)P-labelled NF-kappa B consensus sequence as probe showed that magnolol pretreatment reduced the density of the shifted bands seen after TNF-alpha-induced activation [13].

Anatomical context of Magnolol

  • CONCLUSIONS: These results provide evidence that, in addition to the presence of antioxidative activity, magnolol is potent in stimulating BK(Ca) channel activity in tracheal smooth muscle cells [6].
  • Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils [14].
  • 3. Magnolol (5 and 10 microM) significantly reduced the binding of the human monocytic cell line, U937, to TNF-alpha-stimulated HAECs (58.4 and 56.4% inhibition, respectively) [13].
  • 5. Taken together, these data demonstrate that magnolol inhibits TNF-alpha-induced nuclear translocation of NF-kappa B p65 and thereby suppresses expression of VCAM-1, resulting in reduced adhesion of leukocytes [13].
  • Intravenous pretreatment with magnolol protects myocardium against stunning [15].

Associations of Magnolol with other chemical compounds


Gene context of Magnolol


Analytical, diagnostic and therapeutic context of Magnolol


  1. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells. Lin, S.Y., Chang, Y.T., Liu, J.D., Yu, C.H., Ho, Y.S., Lee, Y.H., Lee, W.S. Mol. Carcinog. (2001) [Pubmed]
  2. Effector mechanism of magnolol-induced apoptosis in human lung squamous carcinoma CH27 cells. Yang, S.E., Hsieh, M.T., Tsai, T.H., Hsu, S.L. Br. J. Pharmacol. (2003) [Pubmed]
  3. Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells. Hsu, Y.F., Lee, T.S., Lin, S.Y., Hsu, S.P., Juan, S.H., Hsu, Y.H., Zhong, W.B., Lee, W.S. Mol. Carcinog. (2007) [Pubmed]
  4. Magnolol attenuates peroxidative damage and improves survival of rats with sepsis. Kong, C.W., Tsai, K., Chin, J.H., Chan, W.L., Hong, C.Y. Shock (2000) [Pubmed]
  5. Carbon nanotube/poly(methyl methacrylate) composite electrode for capillary electrophoretic measurement of honokiol and magnolol in Cortex Magnoliae Officinalis. Yao, X., Xu, X., Yang, P., Chen, G. Electrophoresis (2006) [Pubmed]
  6. Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol. Wu, S.N., Chen, C.C., Li, H.F., Lo, Y.K., Chen, S.A., Chiang, H.T. Thorax (2002) [Pubmed]
  7. Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells. Zhai, H., Nakade, K., Mitsumoto, Y., Fukuyama, Y. Eur. J. Pharmacol. (2003) [Pubmed]
  8. The inhibitory effect of magnolol on cutaneous permeability in mice is probably mediated by a nonselective vascular hyporeactivity to mediators. Wang, J.P., Raung, S.L., Chen, C.C., Kuo, J.S., Teng, C.M. Naunyn Schmiedebergs Arch. Pharmacol. (1993) [Pubmed]
  9. Magnolol decreases body temperature by reducing 5-hydroxytryptamine release in the rat hypothalamus. Hsieh, M.T., Chueh, F.Y., Lin, M.T. Clin. Exp. Pharmacol. Physiol. (1998) [Pubmed]
  10. Effects of magnolol (5,5'-diallyl-2,2'-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Sohn, E.J., Kim, C.S., Kim, Y.S., Jung, D.H., Jang, D.S., Lee, Y.M., Kim, J.S. Life Sci. (2007) [Pubmed]
  11. Catecholaminergic mechanisms-mediated hypothermia induced by magnolol in rats. Hsieh, M.T., Chueh, F.Y., Lin, S.M., Chueh, F.S., Chen, C.F., Lin, M.T. Jpn. J. Pharmacol. (1998) [Pubmed]
  12. Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors. Inhibition by magnolol and honokiol from Magnoliae cortex. Yamazaki, R., Sugatani, J., Fujii, I., Kuroyanagi, M., Umehara, K., Ueno, A., Suzuki, Y., Miwa, M. Biochem. Pharmacol. (1994) [Pubmed]
  13. Magnolol attenuates VCAM-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in the aorta of cholesterol-fed rabbits. Chen, Y.H., Lin, S.J., Chen, J.W., Ku, H.H., Chen, Y.L. Br. J. Pharmacol. (2002) [Pubmed]
  14. Mechanisms of the influence of magnolol on eicosanoid metabolism in neutrophils. Hsu, M.F., Lu, M.C., Tsao, L.T., Kuan, Y.H., Chen, C.C., Wang, J.P. Biochem. Pharmacol. (2004) [Pubmed]
  15. Intravenous pretreatment with magnolol protects myocardium against stunning. Huang, C.H., Hong, C.Y., Tsai, S.K., Lai, S.T., Weng, Z.C., Chih, C.L., Hsieh, Y.H. Planta Med. (2000) [Pubmed]
  16. Magnolol from Magnolia officinalis inhibits 11beta-hydroxysteroid dehydrogenase without increases of corticosterone and thymocyte apoptosis in mice. Horigome, H., Homma, M., Hiran, T., Oka, K., Niitsuma, T., Hayashi, T. Planta Med. (2001) [Pubmed]
  17. Signaling pathway of magnolol-stimulated lipolysis in sterol ester-loaded 3T3-L1 preadipocyes. Huang, S.H., Shen, W.J., Yeo, H.L., Wang, S.M. J. Cell. Biochem. (2004) [Pubmed]
  18. Magnolol induces apoptosis in vascular smooth muscle. Chen, J.H., Wu, C.C., Hsiao, G., Yen, M.H. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  19. The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus. Lu, Y.C., Chen, H.H., Ko, C.H., Lin, Y.R., Chan, M.H. Naunyn Schmiedebergs Arch. Pharmacol. (2003) [Pubmed]
  20. Herbal remedy magnolol suppresses IL-6-induced STAT3 activation and gene expression in endothelial cells. Chen, S.C., Chang, Y.L., Wang, D.L., Cheng, J.J. Br. J. Pharmacol. (2006) [Pubmed]
  21. Magnolol stimulates steroidogenesis in rat adrenal cells. Wang, S.M., Lee, L.J., Huang, Y.T., Chen, J.J., Chen, Y.L. Br. J. Pharmacol. (2000) [Pubmed]
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