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MeSH Review

Medicine, Kampo

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Disease relevance of Medicine, Kampo


High impact information on Medicine, Kampo

  • Choto-san (kampo Medicine) for the treatment of headache [6].
  • PURPOSE: Kampo medicine Hangeshashin-to (TJ-14) which contains baicalin, a beta-glucuronidase inhibitor, alleviates diarrhea induced by irinotecan (CPT-11) [7].
  • Repair of amyloid beta(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to [8].
  • Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver [9].
  • The rats were divided into five groups: sham operated (Sham); ovariectomized (OVX); OVX given traditional Chinese (Kampo) medicine, Unkei-to; OVX given 17 beta-estradiol; and OVX given the estradiol vehicle, respectively [10].

Chemical compound and disease context of Medicine, Kampo


Biological context of Medicine, Kampo


Anatomical context of Medicine, Kampo

  • The effects of antioxidative enzymes (superoxide dismutase, catalase), of several drugs of natural origin (e.g. Kampo Medicines) and synthetic agents (e.g. stobadine, nitrosopine, ACE inhibitors) suggest that smooth muscle tissues are useful models to study ROS action and drug intervention in ROS induced injuries [21].
  • These Kampo medicines, especially TJ-35 scavenged superoxide generated from the hypoxanthine-xanthine oxidase system, and slightly inhibited the superoxide generation from polymorphonuclear leukocytes stimulated by phorbol myristate acetate or opsonized zymosan [22].
  • We recently found that Unkei-to, one of the Japanese Kampo medicines, stimulated CINC secretion by rat anterior pituitary cells and the pituitary folliculo-stellate (FS)-like cell line (TtT/GF) [23].
  • These findings suggest that the Kampo prescription Sho-saiko-to suppresses cytotoxicity or TNF-alpha production in macrophages treated with endotoxin and that it may be useful in improving septic shock symptoms [24].

Associations of Medicine, Kampo with chemical compounds

  • Sho-saiko-to (SST), Keishi-bukuryo-gan (KBG), and Shakuyaku-kanzo-to (SKT) are Japanese modified traditional Chinese herbal medicines (Kampo medicines) consisting of 7, 5, and 2 medical plants, respectively [25].
  • The administration of three Kampo medicines and 17beta-estradiol to OVX rats preserved the fine particle surface of the trabecular bone [26].
  • The acidic polysaccharide fraction (F-5-2) from "Juzen-Taiho-To" (TJ-48), a Kampo (Japanese herbal) medicine prepared by decocting a prescription of 10 kinds of herbs, has potent mitogenic activity [27].
  • Platelet-activating factor (PAF) in allergic diseases: inhibitory effects of anti-allergic drugs, ketotifen and three kampo medicines on PAF production [28].
  • The Kampo medicine, Ninjin-yoei-to, scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion as did ascorbic acid and alpha-tocopherol [29].

Gene context of Medicine, Kampo

  • CONCLUSIONS: Frequently used Kampo medicines may interact with Western drugs, which are substrates for CYP3A4, CYP2C9 and CYP1A2 [30].
  • Furthermore, this study evaluated the effect of the Japanese herbal (kampo) medicine Keishi-bukuryo-gan from the aspect of CGRP regulation [31].
  • We examined the effect of Dai-kenchu-to (DKCT), a traditional Chinese (Kampo) medicine, on the levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in plasma from 24 healthy subjects [32].
  • This study indicates that Kampo medicines are useful for reducing the adverse effects accompanying IFN treatment in patients with chronic hepatitis C without reducing the antiviral effects [33].
  • We have already reported the existence of aldose reductase inhibitors in some kampo medicines [34].

Analytical, diagnostic and therapeutic context of Medicine, Kampo

  • Simultaneous determination of ephedrine, pseudoephedrine, norephedrine and methylephedrine in Kampo medicines by high-performance liquid chromatography [35].
  • In the present study we conducted rat liver perfusion using the HMG Co A reductase inhibitor (CS-514) and Kampo medicine (Daisaikoto) to elucidate the mechanism of the effect of dietary cholesterol on hepatic lipoprotein and apolipoprotein synthesis [36].
  • Traditional Chinese Medicine (TCM) is now called "Kampo Medicine" in Japan. What is really needed for the treatment of human sickness and what is really wanted by sick people is medical care tailored to the particular patient, which respects the individual characteristics and personality of the patient [37].
  • In this study, we examined whether in vivo keishi-bukuryo-gan (a Kampo formulation) could prevent the progression of atherosclerosis in cholesterol-fed rabbits, an animal model for hypercholesterolaemia [38].
  • The patient was managed with the following medications: (1) tocolysis with ritodrine infusion, (2) 10%maltose infusion therapy (1500mL/day), (3) antibiotic infusion (cefotaxim sodium, 2 g/dayx7) and (4) kampo therapy with Sairei-to until delivery [39].


  1. Protective effect of oral administration of a pectic polysaccharide fraction from a Kampo (Japanese herbal) medicine "Juzen-Taiho-To" on adverse effects of cis-diaminedichloroplatinum. Kiyohara, H., Matsumoto, T., Komatsu, Y., Yamada, H. Planta Med. (1995) [Pubmed]
  2. Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats. Takasuna, K., Kasai, Y., Kitano, Y., Mori, K., Kobayashi, R., Hagiwara, T., Kakihata, K., Hirohashi, M., Nomura, M., Nagai, E. Jpn. J. Cancer Res. (1995) [Pubmed]
  3. Effects of TJ-9 Sho-saiko-to (kampo medicine) on interferon gamma and antibody production specific for hepatitis B virus antigen in patients with type B chronic hepatitis. Kakumu, S., Yoshioka, K., Wakita, T., Ishikawa, T. Int. J. Immunopharmacol. (1991) [Pubmed]
  4. Inhibition of ganciclovir-resistant human cytomegalovirus replication by Kampo (Japanese herbal medicine). Murayama, T., Yamaguchi, N., Iwamoto, K., Eizuru, Y. Antivir. Chem. Chemother. (2006) [Pubmed]
  5. Sho-saiko-to, a traditional Kampo medicine, enhances the anti-HIV-1 activity of lamivudine (3TC) in vitro. Piras, G., Makino, M., Baba, M. Microbiol. Immunol. (1997) [Pubmed]
  6. Choto-san (kampo Medicine) for the treatment of headache. Dohi, K., Aruga, T., Satoh, K., Shioda, S. Headache. (2004) [Pubmed]
  7. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Mori, K., Kondo, T., Kamiyama, Y., Kano, Y., Tominaga, K. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  8. Repair of amyloid beta(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Tohda, C., Tamura, T., Komatsu, K. Brain Res. (2003) [Pubmed]
  9. Orally administered decoction of Kampo (Japanese herbal) medicine, "Juzen-Taiho-To" modulates cytokine secretion and induces NKT cells in mouse liver. Matsumoto, T., Sakurai, M.H., Kiyohara, H., Yamada, H. Immunopharmacology (2000) [Pubmed]
  10. Thermal analysis of bones from ovariectomized rats. Okamoto, Y., Hidaka, S., Yamada, Y., Ouchi, K., Miyazaki, K., Liu, S.Y. J. Biomed. Mater. Res. (1998) [Pubmed]
  11. Comparing the effects of estrogen and an herbal medicine on peripheral blood flow in post-menopausal women with hot flashes: hormone replacement therapy and gui-zhi-fu-ling-wan, a Kampo medicine. Ushiroyama, T., Ikeda, A., Sakuma, K., Ueki, M. Am. J. Chin. Med. (2005) [Pubmed]
  12. Effect of processed Aconiti tuber on catecholamine and indoleamine contents in brain in rats. Ikeda, Y., Oyama, T., Taki, M. Acta anaesthesiologica Belgica. (1994) [Pubmed]
  13. Effects of 9 Kampo medicines clinically used in hypertension on hemodynamic changes induced by theophylline in rats. Sanae, F., Komatsu, Y., Amagaya, S., Chisaki, K., Hayashi, H. Biol. Pharm. Bull. (2000) [Pubmed]
  14. Protective effect of juzen-taiho-to against carboplatin-induced toxic side effects in mice. Sugiyama, K., Ueda, H., Ichio, Y. Biol. Pharm. Bull. (1995) [Pubmed]
  15. Effects of Byakko-ka-ninjin-to on salivary secretion and bladder function in rats. Sakaguchi, M., Goto, K., Ichiki, H., Hattori, N., Iizuka, A., Yamamoto, M., Takeda, S., Ishige, A., Aburada, M., Yasuda, M., Yamamoto, T. Journal of ethnopharmacology. (2005) [Pubmed]
  16. Effect of oral administration of a pectic polysaccharide fraction from a kampo (Japanese herbal) medicine "juzen-taiho-to" on antibody response of mice. Kiyohara, H., Matsumoto, T., Takemoto, N., Kawamura, H., Komatsu, Y., Yamada, H. Planta Med. (1995) [Pubmed]
  17. Age-related increase in nitric oxide synthase activity in senescence accelerated mouse brain and the effect of long-term administration of superoxide radical scavenger. Inada, K., Yokoi, I., Kabuto, H., Habu, H., Mori, A., Ogawa, N. Mech. Ageing Dev. (1996) [Pubmed]
  18. Effect of three Japanese kampo medicines on platelet activation by monoclonal anti-platelet membrane glycoprotein antibodies. Kawakatsu, T., Nomura, S., Kido, H., Yamaguchi, K., Fukuroi, T., Suzuki, M., Yanabu, M., Kokawa, T., Yasunaga, K. Am. J. Chin. Med. (1994) [Pubmed]
  19. Effects of switching to wen-jing-tang (unkei-to) from preceding herbal preparations selected by eight-principle pattern identification on endocrinological status and ovulatory induction in women with polycystic ovary syndrome. Ushiroyama, T., Hosotani, T., Mori, K., Yamashita, Y., Ikeda, A., Ueki, M. Am. J. Chin. Med. (2006) [Pubmed]
  20. Pharmacokinetic interactions between Japanese traditional medicine (kampo) and modern medicine (III). Effect of Sho-seiryu-to on the pharmacokinetics of azelastine hydrochloride in rats. Makino, T., Inagaki, T., Komatsu, K., Kano, Y. Biol. Pharm. Bull. (2004) [Pubmed]
  21. Reactive oxygen species induced smooth muscle responses in the intestine, vessels and airways and the effect of antioxidants. Bauer, V., Sotníková, R., Machová, J., Mátyás, S., Pucovský, V., Stefek, M. Life Sci. (1999) [Pubmed]
  22. Antioxidant properties of antiulcer Kampo medicines. Takahashi, S., Yoshikawa, T., Naito, Y., Minamiyama, Y., Tanigawa, T., Kondo, M. Free Radic. Res. Commun. (1993) [Pubmed]
  23. Evidence that folliculo-stellate cells mediate the inhibitory effect of Japanese kampo medicine, unkei-to, on growth hormone secretion in rat anterior pituitary cell cultures. Koike, K., Zhang, Z.X., Sakamoto, Y., Miyake, A., Inoue, M. Am. J. Reprod. Immunol. (1998) [Pubmed]
  24. Preventive effects of a traditional Chinese medicine (Sho-saiko-to) on endotoxin-induced cytotoxicity and tumor necrosis factor-alpha production in J774A.1 Cells. Sakaguchi, S., Furusawa, S. Biol. Pharm. Bull. (2004) [Pubmed]
  25. Suppression by kampo medicines in preneoplastic mammary hyperplastic alveolar nodules of SHN virgin mice. Sakamoto, S., Muroi, N., Matsuda, M., Tajima, M., Kudo, H., Kasahara, N., Suzuki, S., Sugiura, Y., Kuwa, K., Namiki, H. Planta Med. (1993) [Pubmed]
  26. Preventive effects of traditional Chinese (Kampo) medicines on experimental osteoporosis induced by ovariectomy in rats. Hidaka, S., Okamoto, Y., Nakajima, K., Suekawa, M., Liu, S.Y. Calcif. Tissue Int. (1997) [Pubmed]
  27. Characterization of mitogenic pectic polysaccharides from kampo (Japanese herbal) medicine "juzen-taiho-to". Kiyohara, H., Takemoto, N., Komatsu, Y., Kawamura, H., Hosoya, E., Yamada, H. Planta Med. (1991) [Pubmed]
  28. Platelet-activating factor (PAF) in allergic diseases: inhibitory effects of anti-allergic drugs, ketotifen and three kampo medicines on PAF production. Nakamura, T., Kuriyama, M., Ishihara, K., Matsumura, Y., Miyamoto, T. Lipids (1991) [Pubmed]
  29. Changes of materials that scavenge 1,1-diphenyl-2-picrylhydrazyl radicals in plasma by per-oral administration of Kampo medicine, Ninjin-yoei-to in rats. Egashira, T., Takayama, F., Komatsu, Y. J. Pharm. Pharmacol. (2003) [Pubmed]
  30. In vitro inhibitory effects of Kampo medicines on metabolic reactions catalyzed by human liver microsomes. Takahashi, K., Uejima, E., Morisaki, T., Takahashi, K., Kurokawa, N., Azuma, J. Journal of clinical pharmacy and therapeutics. (2003) [Pubmed]
  31. Menopausal hot flash and calciotonin gene-related peptide; effect of Keishi-bukuryo-gan, a kampo medicine, related to plasma calciotonin gene-related peptide level. Chen, J.T., Shiraki, M. Maturitas. (2003) [Pubmed]
  32. Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma. Nagano, T., Itoh, H., Takeyama, M. Biol. Pharm. Bull. (1999) [Pubmed]
  33. The efficacy of herbal medicine (kampo) in reducing the adverse effects of IFN-beta in chronic hepatitis C. Kainuma, M., Hayashi, J., Sakai, S., Imai, K., Mantani, N., Kohta, K., Mitsuma, T., Shimada, Y., Kashiwagi, S., Terasawa, K. Am. J. Chin. Med. (2002) [Pubmed]
  34. Anti-platelet action of GU-7, a 3-arylcoumarin derivative, purified from glycyrrhizae radix. Tawata, M., Yoda, Y., Aida, K., Shindo, H., Sasaki, H., Chin, M., Onaya, T. Planta Med. (1990) [Pubmed]
  35. Simultaneous determination of ephedrine, pseudoephedrine, norephedrine and methylephedrine in Kampo medicines by high-performance liquid chromatography. Okamura, N., Miki, H., Harada, T., Yamashita, S., Masaoka, Y., Nakamoto, Y., Tsuguma, M., Yoshitomi, H., Yagi, A. Journal of pharmaceutical and biomedical analysis. (1999) [Pubmed]
  36. Production of apolipoprotein E-rich LDL by the liver. The effect of dietary cholesterol and some lipid lowering agents. Teramoto, T., Matsushima, T., Horie, Y., Watanabe, T. Ann. N. Y. Acad. Sci. (1990) [Pubmed]
  37. Proposal of practicing Japanese Kampo in menopausal medicine. Ushiroyama, T. Journal of psychosomatic obstetrics and gynaecology. (2005) [Pubmed]
  38. Keishi-bukuryo-gan prevents the progression of atherosclerosis in cholesterol-fed rabbit. Sekiya, N., Tanaka, N., Itoh, T., Shimada, Y., Goto, H., Terasawa, K. Phytotherapy research : PTR. (1999) [Pubmed]
  39. Massive subchorionic hematoma (Breus' mole) complicated by intrauterine growth retardation. Nishida, N., Suzuki, S., Hamamura, Y., Igarashi, K., Hayashi, Z., Sawa, R., Yoneyama, Y., Asakura, H., Kawabata, K., Shima, Y., Shin, S., Araki, T. Journal of Nippon Medical School = Nihon Ika Daigaku zasshi. (2001) [Pubmed]
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