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Chemical Compound Review:

AC1NPKIS 2-nitrobenzoate

Synonyms: SureCN160082, CPD-9168, CHEBI:25619, ZINC00080841, A830533, ...

This record was replaced with 11087.

Iwaki, H. et al., Muraki, T. et al., Jones, R.M. et al., Khailova, L.S. et al., Hasegawa, Y. et al., et al.

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Disease relevance of NSC 9576

Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7 [1].
Degradation of 2-Nitrobenzoate by Burkholderia terrae Strain KU-15 [2].

High impact information on NSC 9576

Transcriptional fusion studies demonstrated that NagR regulates the expression of the nag operon positively in the presence of salicylate and to a lesser extent in the presence of 2-nitrobenzoate [3].
All mutants are defective in their thioredoxin reduction activity, although they still show reactivity with 5,5'-dithiobis (2-nitrobenzoate) [4].
Titration with 5,5'-dithiobis (2-nitrobenzoate) gave 19.1 +/- 2.2 sulfhydryl groups/mol ATPase [5].
Metabolite analyses by thin layer chromatography and high pressure liquid chromatography indicated that 3-hydroxyanthranilate is an intermediate of 2-nitrobenzoate metabolism in KU-7 cells [6].
Metabolite analyses by high-performance liquid chromatography indicated that 3-hydroxyanthranilate, anthranilate, and catechol are intermediates of 2-nitrobenzoate metabolism in strain KU-15 [2].

Chemical compound and disease context of NSC 9576

Bacterial strain KU-15, identified as a Burkholderia terrae by 16S rRNA gene sequence analysis, was one of 11 new isolates that grew on 2-nitrobenzoate as sole source of carbon and nitrogen [2].

Biological context of NSC 9576

The kinetics of inactivation of the pyruvate dehydrogenase component of the pigeon breast muscle pyruvate dehydrogenase complex in the presence of 5,5'-dithiobis (2-nitrobenzoate) is biphasic [7].

Associations of NSC 9576 with other chemical compounds

Various types of SH-reactive agents, except 5,5'-dithio-bis (2-nitrobenzoate) (DTNB), were found to inhibit adherence of mouse peritoneal M phi to serum-coated Falcon surfaces [8].

Analytical, diagnostic and therapeutic context of NSC 9576

The modified enzyme was shown to contain only 5 free sulfhydryl groups upon 5,5'-dithiobis (2-nitrobenzoate) titration as compared with 6 in the unmodified enzyme [9].

References

Prokaryotic homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase in the 2-nitrobenzoate degradation pathway of Pseudomonas fluorescens strain KU-7. Muraki, T., Taki, M., Hasegawa, Y., Iwaki, H., Lau, P.C. Appl. Environ. Microbiol. (2003) [Pubmed]
Degradation of 2-Nitrobenzoate by Burkholderia terrae Strain KU-15. Iwaki, H., Hasegawa, Y. Biosci. Biotechnol. Biochem. (2007) [Pubmed]
The naphthalene catabolic (nag) genes of Ralstonia sp. strain U2 are an operon that is regulated by NagR, a LysR-type transcriptional regulator. Jones, R.M., Britt-Compton, B., Williams, P.A. J. Bacteriol. (2003) [Pubmed]
The role of the C-terminus for catalysis of the large thioredoxin reductase from Plasmodium falciparum. Gilberger, T.W., Bergmann, B., Walter, R.D., Müller, S. FEBS Lett. (1998) [Pubmed]
Sulfhydryl groups of the F1 adenosine triphosphatase of Escherichia coli and the stoichiometry of the subunits. Stan-Lotter, H., Bragg, P.D. Arch. Biochem. Biophys. (1984) [Pubmed]
A novel degradative pathway of 2-nitrobenzoate via 3-hydroxyanthranilate in Pseudomonas fluorescens strain KU-7. Hasegawa, Y., Muraki, T., Tokuyama, T., Iwaki, H., Tatsuno, M., Lau, P.C. FEMS Microbiol. Lett. (2000) [Pubmed]
Study on the role of SH-groups in the activity of muscle pyruvate dehydrogenase. Khailova, L.S., Aleksandrovich, O.V., Severin, S.E. Biochem. Int. (1983) [Pubmed]
Effect of heparin on the reactivity of SH-groups in the macrophage membrane. Kelemenics, K., Jókay, I., Földes, I. Acta physiologica Hungarica. (1986) [Pubmed]
Identification of cysteine-319 as the target amino acid of 8-[(4-bromo-2,3-dioxobutyl)thio]adenosine 5'-triphosphate in bovine liver glutamate dehydrogenase. Ozturk, D.H., Colman, R.F. Biochemistry (1991) [Pubmed]

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