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Chemical Compound Review

Vanadocene     cyclopentane; vanadium

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Disease relevance of Vanadocene


High impact information on Vanadocene


Biological context of Vanadocene


Anatomical context of Vanadocene

  • All seven chelate complexes of vanadocene elicited potent spermicidal activity at micromolar concentrations (EC50 values: 3.9-106 microM) without affecting the sperm acrosome integrity [9].

Analytical, diagnostic and therapeutic context of Vanadocene

  • Both the unsubstituted and the pentamethyl-substituted vanadocene induced rapid sperm immobilization (T(1/2) < 15 s) [10].
  • This study sought to determine the vaginal contraceptive activity of vanadocene dithiocarbamate (VDDTC), a stable vanadocene (IV)-chelated complex, using the standard rabbit model as well as the domestic pig as a physiologically relevant animal model for contraception [11].


  1. Apoptosis-inducing vanadocene compounds against human testicular cancer. Ghosh, P., D'Cruz, O.J., Narla, R.K., Uckun, F.M. Clin. Cancer Res. (2000) [Pubmed]
  2. Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  3. Subchronic (13-week) toxicity studies of intravaginal administration of spermicidal vanadocene acetylacetonato monotriflate in mice. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Toxicology (2002) [Pubmed]
  4. Spermicidal activity of metallocene complexes containing vanadium(IV) in humans. D'Cruz, O.J., Ghosh, P., Uckun, F.M. Biol. Reprod. (1998) [Pubmed]
  5. Investigation of vanadocene(IV) alpha-amino acid complexes: synthesis, structure, and behavior in physiological solutions, human plasma, and blood. Vinklárek, J., Palácková, H., Honzícek, J., Holubová, J., Holcapek, M., Císarová, I. Inorganic chemistry. (2006) [Pubmed]
  6. Vanadocene-mediated in vivo male germ cell apoptosis. D'Cruz, O.J., Uckun, F.M. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  7. Molecular genotoxicity profiles of apoptosis-inducing vanadocene complexes. Aubrecht, J., Narla, R.K., Ghosh, P., Stanek, J., Uckun, F.M. Toxicol. Appl. Pharmacol. (1999) [Pubmed]
  8. Vanadocenes as potent anti-proliferative agents disrupting mitotic spindle formation in cancer cells. Navara, C.S., Benyumov, A., Vassilev, A., Narla, R.K., Ghosh, P., Uckun, F.M. Anticancer Drugs (2001) [Pubmed]
  9. Spermicidal activity of chelated complexes of bis(cyclopentadienyl)vanadium(IV). D'Cruz, O.J., Ghosh, P., Uckun, F.M. Mol. Hum. Reprod. (1998) [Pubmed]
  10. Evaluation of boar sperm as a model system to study the mechanism of spermicidal activity of vanadocenes. D'Cruz, O.J., Vassilev, A., Uckun, F.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  11. Vaginal contraceptive activity of a chelated vanadocene. D'Cruz, O.J., Uckun, F.M. Contraception. (2005) [Pubmed]
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