Chemical Compound Review:
WHI-07 methyl(2S)-2-[[[(2R,3S,5R)-3- azido-5-(5...
Synonyms:
AC1NUK89
- Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats. D'Cruz, O.J., Waurzyniak, B., Uckun, F.M. Antimicrob. Agents Chemother. (2004)
- Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07). D'Cruz, O.J., Uckun, F.M. J. Antimicrob. Chemother. (2002)
- Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07). D'Cruz, O.J., Venkatachalam, T.K., Uckun, F.M. Biol. Reprod. (2000)
- Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice. D'Cruz, O.J., Uckun, F.M. Toxicol. Sci. (2001)
- Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm. D'Cruz, O.J., Venkatachalam, T.K., Uckun, F.M. Biol. Reprod. (2001)
- Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus. D'Cruz, O.J., Venkatachalam, T.K., Zhu, Z., Shih, M.J., Uckun, F.M. Biol. Reprod. (1998)
- Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities. D'Cruz, O.J., Shih, M.J., Yiv, S.H., Chen, C.L., Uckun, F.M. Mol. Hum. Reprod. (1999)
- Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits. D'Cruz, O.J., Uckun, F.M. Fertil. Steril. (2003)
- Developmental toxicology studies of WHI-07, a novel nucleoside analogue-based dual-function microbicide, administered intravaginally to rabbits. D'Cruz, O.J., Erbeck, D., Uckun, F.M. Toxicologic pathology. (2003)
- Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07). D'Cruz, O.J., Uckun, F.M. Journal of applied toxicology : JAT. (2001)
- Antileukemic activity and cellular metabolism of the aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07). Uckun, F.M., Tai, H.L., D'Cruz, O.J. Arzneimittel-Forschung. (2005)