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Chemical Compound Review

AC1NQXHH     (Z)-7-[(1R,2S,3R)-3-hydroxy- 5-oxo-2-[(E)-3...

Synonyms: CHEBI:15547, HMDB03175, SureCN11681397, BML1-F11, LMFA03010030, ...
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Disease relevance of 15-Oxo-PGE2

  • Human serum albumin, in a concentration-dependent fashion, catalyzed the dehydration of 15-keto-PGE2 with the concurrent generation of this chromophore (lambda max = 505 nm, epsilon = 35,000) [1].

High impact information on 15-Oxo-PGE2


Anatomical context of 15-Oxo-PGE2


Associations of 15-Oxo-PGE2 with other chemical compounds

  • The absorption rates of PGE2 released from tablets, gel and pessary bases inserted into the vagina for the induction of labour in a total of 27 patients have been measured by means of serial plasma 15-keto-PGE2 levels [8].


  1. Albumin-eicosanoid interactions. A model system to determine their attributes and inhibition. Fitzpatrick, F.A., Liggett, W.F., Wynalda, M.A. J. Biol. Chem. (1984) [Pubmed]
  2. A novel cyclooxygenase metabolite of arachidonic acid. Morrison, A.R., McLaughlin, L., Bloch, M., Needleman, P. J. Biol. Chem. (1984) [Pubmed]
  3. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Nishigaki, N., Negishi, M., Ichikawa, A. Mol. Pharmacol. (1996) [Pubmed]
  4. Biosynthesis of prostaglandin D2, 15-ketoprostaglandin E2, and hydroxy fatty acids by ram seminal vesicle microsomes. Ravikumar, P.R., Pai, J.K., Zmijewski, M.J., Sih, C.J. Journal of pharmaceutical sciences. (1979) [Pubmed]
  5. Fetal guinea pig brain 15-hydroxyprostaglandin dehydrogenase: ontogeny and effect of ethanol. Treissman, D., Brien, J.F. Alcohol (1991) [Pubmed]
  6. Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans. el Attar, T.M., Lin, H.S., Vanderhoek, J.Y. Cancer Lett. (1985) [Pubmed]
  7. Prostaglandin E2 catabolism in the spinal nerve roots of the cat. Bishai, I., Coceani, F. Can. J. Physiol. Pharmacol. (1980) [Pubmed]
  8. The systemic absorption from the vagina of prostaglandin E2 administered for the induction of labour. Gordon-Wright, A.P., Elder, M.G. Prostaglandins (1979) [Pubmed]
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