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MeSH Review


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Disease relevance of Pessaries


Psychiatry related information on Pessaries


High impact information on Pessaries


Chemical compound and disease context of Pessaries


Biological context of Pessaries


Anatomical context of Pessaries

  • A cervical tear occurred in two of 20 patients treated with PGE2 pessaries and all 20 required further dilatation of the cervix [18].
  • Our conclusion is that patients who require an induction of labor, when artificial rupture of the membranes is not feasible, benefit from the use of prostaglandin pessaries before the administration of oxytocin [21].
  • On Day 5 after pessary insertion, PGF2alpha (15 mg) was given i.m. At pessary removal, 400 IU of eCG were administered i.m. Ewes were inseminated 48-52 h after pessary removal using fresh diluted semen (200 x 10(6) to 350 x 10(6) spermatozoa per 0.2 ml) pooled from the same four rams each day during the experiment [22].
  • Blood serum lipids and cholesterol of the ewe during intravaginal pessary treatment [23].
  • We compared the efficacy and safety of estriol-containing vaginal pessary use with those of oral nitrofurantoin macrocrystal (NM) therapy for preventing urinary tract infection (UTI) in postmenopausal women with recurrent UTI [24].

Associations of Pessaries with chemical compounds

  • Vaginal pessaries containing 3 mg of prostaglandin E2 were used to induce labour in 200 patients with variable induction features [25].
  • Prostaglandin E, pessaries for induction of labour [25].
  • The serum concentrations of miconazole were measured in 11 healthy adult females for 72 hours following a single 1200 mg vaginal pessary [26].
  • The mean (+/- standard deviation) number of abnormal events was significantly greater in women treated with misoprostol (5.0 +/- 5.9) versus the dinoprostone pessary (1.6 +/- 2.5) and gel (2.2 +/- 3.1) (P < .05) [27].
  • Serum concentrations of oestradiol increased progressively in control sheep during the 48 h immediately after pessary removal [28].

Gene context of Pessaries

  • Animals were passively immunized against GnRH (groups 2-5, n = 6) or the carrier protein, keyhole limpet hemocyanin (KLH; group 1, n = 6), at the time of pessary removal (PR) [29].
  • Oestrous cycles were synchronized using progestagen pessaries and either unstimulated or superovulated with 200 mg pig FSH [30].
  • Three crossbred ewes synchronized for oestrus with ovarian autotransplants were infused with TGF-alpha (30 micrograms in 12 h) via the ovarian artery for 12 h before withdrawal of progestagen pessary [31].
  • RESULTS: Women with fetal fibronectin in their cervico-vaginal secretion had better cervical response to PGE2 pessaries and required fewer doses for induction of labor and they took a shorter time interval from induction to delivery [32].
  • However, when progesterone (250 mg) and oestradiol benzoate (7-5 mg) were given intramuscularly on the day of pessary insertion corpus luteum development was inhibited in animals treated at day 2 and was regressed in animals at day 12 [33].

Analytical, diagnostic and therapeutic context of Pessaries


  1. Pessary test: simple prognostic test in women with stress urinary incontinence. Bergman, A., Bhatia, N.N. Urology (1984) [Pubmed]
  2. The use of povidone-iodine ('Betadine') pessaries in the treatment of candidal and trichomonal vaginitis. Henderson, J.N., Tait, I.B. Current medical research and opinion. (1975) [Pubmed]
  3. Treatment of vaginal candidiasis with miconazole. Hilton, A.L., Warnock, D.W., Milne, J.D., Scott, A.J. Current medical research and opinion. (1977) [Pubmed]
  4. Investigation of the efficacy of progesterone pessaries in the relief of symptoms of premenstrual syndrome. progesterone Study Group. Magill, P.J. The British journal of general practice : the journal of the Royal College of General Practitioners. (1995) [Pubmed]
  5. Treatment of severe postpartum hemorrhage by rectally administered gemeprost pessaries. Craig, S., Chau, H., Cho, H. Journal of perinatal medicine. (1999) [Pubmed]
  6. A pharmacoepidemiological approach to investigating inappropriate physician prescribing in a managed care setting in Israel. Kahan, N.R., Blackman, S., Kutz, C., Waitman, D.A. The American journal of managed care. (2005) [Pubmed]
  7. Controlled-release prostaglandin E2 pessary. Taylor, A.V., MacKenzie, I.Z. Lancet (1990) [Pubmed]
  8. Cardiac standstill induced by prostaglandin pessaries. Kalra, P.A., Litherland, D., Sallomi, D.F., Critchley, H.O., Falconer, G.F., Holmes, A.M. Lancet (1989) [Pubmed]
  9. Induction of therapeutic abortion in early pregnancy with mifepristone in combination with prostaglandin pessary. Rodger, M.W., Baird, D.T. Lancet (1987) [Pubmed]
  10. Very early abortion by prostaglandins. Mackenzie, I.Z., Embrey, M.P., Davies, A.J., Guillebaud, J. Lancet (1978) [Pubmed]
  11. Comparison of single administration with an ovule of 600 mg fenticonazole versus a 500 mg clotrimazole vaginal pessary in the treatment of vaginal candidiasis. Wiest, W., Azzollini, E., Ruffmann, R. J. Int. Med. Res. (1989) [Pubmed]
  12. Metronidazole pessaries compared with placebo in the treatment of bacterial vaginosis. Bro, F. Scandinavian journal of primary health care. (1990) [Pubmed]
  13. The efficacy of povidone-iodine pessaries in a short, low-dose treatment regime on candidal, trichomonal and non-specific vaginitis. Yu, H., Tak-Yin, M. Postgraduate medical journal. (1993) [Pubmed]
  14. Phase I safety & preliminary acceptability of nonoxynol-9 vaginal pessary as a vaginal microbicide in low risk women in Pune, India. Joshi, S., Joglekar, N., Ghate, M., Unni, J., Risbud, A., Bentley, M., Shepherd, M., Bollinger, R., Mehendale, S. Indian J. Med. Res. (2003) [Pubmed]
  15. Comparison of clotrimazole, fluconazole and itraconazole in vaginal candidiasis. Woolley, P.D., Higgins, S.P. The British journal of clinical practice. (1995) [Pubmed]
  16. Effects of passive immunization against inhibin-peptide on secretion of follicle-stimulating hormone and ovulation rate in ewes carrying the Booroola fecundity gene. Wheaton, J.E., Thomas, D.L., Kusina, N.T., Gottfredson, R.G., Meyer, R.L. Biol. Reprod. (1996) [Pubmed]
  17. Prostaglandin E2 pessaries to facilitate first trimester aspiration termination. MacKenzie, I.Z., Fry, A. British journal of obstetrics and gynaecology. (1981) [Pubmed]
  18. A comparison of prostaglandin E2 pessaries and laminaria tents for ripening the cervix before termination of pregnancy. Killick, S.R., Vaughan Williams, C.A., Elstein, M. British journal of obstetrics and gynaecology. (1985) [Pubmed]
  19. Comparison of the Foley catheter and dinoprostone pessary for cervical preparation before second trimester abortion. Hackett, G.A., Reginald, P., Paintin, D.B. British journal of obstetrics and gynaecology. (1989) [Pubmed]
  20. Cervical dilatation with pessaries containing a new prostaglandin E1 analogue in patients undergoing induced abortion. Nakano, R. Am. J. Obstet. Gynecol. (1982) [Pubmed]
  21. The effect of vaginal prostaglandin E2 pessaries on induction of labor. Lange, I.R., Collister, C., Johnson, J., Cote, D., Torchia, M., Freund, G., Manning, F.A. Am. J. Obstet. Gynecol. (1984) [Pubmed]
  22. Development of a new transcervical artificial insemination method for sheep: effects of a new transcervical artificial insemination catheter and traversing the cervix on semen quality and fertility. Wulster-Radcliffe, M.C., Lewis, G.S. Theriogenology (2002) [Pubmed]
  23. Blood serum lipids and cholesterol of the ewe during intravaginal pessary treatment. Pareek, P.K., Roychoudhury, P.N., Gowda, H.C. Zentralblatt für Veterinärmedizin. Reihe A. (1977) [Pubmed]
  24. Effectiveness of estriol-containing vaginal pessaries and nitrofurantoin macrocrystal therapy in the prevention of recurrent urinary tract infection in postmenopausal women. Raz, R., Colodner, R., Rohana, Y., Battino, S., Rottensterich, E., Wasser, I., Stamm, W. Clin. Infect. Dis. (2003) [Pubmed]
  25. Prostaglandin E, pessaries for induction of labour. Pearce, J.M., Shepherd, J.H., Sims, C.D. Lancet (1979) [Pubmed]
  26. Systemic absorption of miconazole from the vagina. Daneshmend, T.K. J. Antimicrob. Chemother. (1986) [Pubmed]
  27. Cardiotocographic abnormalities associated with dinoprostone and misoprostol cervical ripening. Ramsey, P.S., Meyer, L., Walkes, B.A., Harris, D., Ogburn, P.L., Heise, R.H., Ramin, K.D. Obstetrics and gynecology. (2005) [Pubmed]
  28. Effect of stress-like concentrations of cortisol on follicular development and the preovulatory surge of LH in sheep. Daley, C.A., Macfarlane, M.S., Sakurai, H., Adams, T.E. J. Reprod. Fertil. (1999) [Pubmed]
  29. Pattern of gonadotropin-releasing hormone (GnRH)-like stimuli sufficient to induce follicular growth and ovulation in ewes passively immunized against GnRH. Sakurai, H., Adams, B.M., Adams, T.E. Biol. Reprod. (1992) [Pubmed]
  30. Effect of nutrition and superovulation on oocyte morphology, follicular fluid composition and systemic hormone concentrations in ewes. O'Callaghan, D., Yaakub, H., Hyttel, P., Spicer, L.J., Boland, M.P. J. Reprod. Fertil. (2000) [Pubmed]
  31. Changes in progesterone secretion following treatment with transforming growth factor alpha (TGF-alpha) during the follicular phase of the sheep oestrous cycle. Murray, J.F., Downing, J.A., Evans, G., Findlay, J.K., Scaramuzzi, R.J. J. Reprod. Fertil. (1994) [Pubmed]
  32. Prediction of cervical response to prostaglandin E2 using fetal fibronectin. Tam, W.H., Tai, S.M., Rogers, M.S. Acta obstetricia et gynecologica Scandinavica. (1999) [Pubmed]
  33. The effects of progesterone and oestrogen treatment in heifers on oestrous cycle control and plasma progesterone levels. Sreenan, J.M., Mulvehill, P. Vet. Rec. (1977) [Pubmed]
  34. Vaginal administration of a single dose of 16, 16 dimethyl prostaglandin E2 p-benzaldehyde semicarbazone ester for pre-operative cervical dilatation in first trimester nulliparae. Karim, S.M., Ratnam, S.S., Prasad, R.N., Wong, Y.M. British journal of obstetrics and gynaecology. (1977) [Pubmed]
  35. Pituitary suppression in ultrasound-monitored frozen embryo replacement cycles. A randomised study. El-Toukhy, T., Taylor, A., Khalaf, Y., Al-Darazi, K., Rowell, P., Seed, P., Braude, P. Hum. Reprod. (2004) [Pubmed]
  36. The application of long- and short-term progestagen treatments for oestrous cycle control in heifers. Sreenan, J.M., Mulvehill, P. J. Reprod. Fertil. (1975) [Pubmed]
  37. Preoperative dilatation of the first-trimester cervix: a comparison between Lamicel and 16,16-dimethyl-trans delta 2 prostaglandin E1 methyl ester pessaries. Welch, C.C., Macpherson, M., Johnson, I.R., Nicolaides, K., Filshie, G.M. Am. J. Obstet. Gynecol. (1984) [Pubmed]
  38. The effect of pre-operative povidone iodine vaginal pessaries on vault infections after hysterectomy. Blackmore, M.A., Turner, G.M., Adams, M.R., Speller, D.C. British journal of obstetrics and gynaecology. (1981) [Pubmed]
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