Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

MK-476 sodium 2-[1-[[(1R)-1-[3-[(E)-2-(7...

Synonyms:

Balani, S.K. et al., Straub, D.A. et al., Guay, D. et al., Cheng, H. et al., Gallant, M. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of montelukast

Montelukast sodium [1-([(1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)- ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio]methyl)cyclopropylacetic acid sodium salt] (MK-476, Singulair) is a potent and selective antagonist of the cysteinyl leukotriene (Cys-LT1) receptor and is under investigation for the treatment of bronchial asthma [1].
In the present study, we evaluated the effect of montelukast (Singulair, Merck, USA) on the cough reflex in an experimental model of allergen-induced rhinitis in guinea pigs [2].

High impact information on montelukast

OBJECTIVE: The study was undertaken to investigate the influence of once-daily treatment with montelukast (Singulair; MSD; Glattbrugg, Switzerland) on levels of exhaled nitric oxide (eNO) and lung function in preschool children with asthma [3].
The safety, tolerability, and pharmacokinetics of intravenous *i.v.) montelukast sodium (Singulair, MK-0476), and the oral bioavailability of montelukast sodium in healthy males and healthy females were studied [4].
The structure-activity relationship of a series of styrylpyridine analogs of MK-0476 (montelukast, Singulair) is described [5].
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair [5].
L-745310, which is structurally related to the potent LTD4 antagonist MK-0476 (Singulair), was found to selectively label a 43-kDa protein in guinea-pig lung membrane previously identified as the LTD4 receptor [6].

References

Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile. Balani, S.K., Xu, X., Pratha, V., Koss, M.A., Amin, R.D., Dufresne, C., Miller, R.R., Arison, B.H., Doss, G.A., Chiba, M., Freeman, A., Holland, S.D., Schwartz, J.I., Lasseter, K.C., Gertz, B.J., Isenberg, J.I., Rogers, J.D., Lin, J.H., Baillie, T.A. Drug Metab. Dispos. (1997) [Pubmed]
Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs. Brozmanova, M., Plevkova, J., Bartos, V., Plank, L., Tatar, M. J. Physiol. Pharmacol. (2005) [Pubmed]
The effect of montelukast on exhaled nitric oxide and lung function in asthmatic children 2 to 5 years old. Straub, D.A., Minocchieri, S., Moeller, A., Hamacher, J., Wildhaber, J.H. Chest (2005) [Pubmed]
Pharmacokinetics, bioavailability, and safety of montelukast sodium (MK-0476) in healthy males and females. Cheng, H., Leff, J.A., Amin, R., Gertz, B.J., De Smet, M., Noonan, N., Rogers, J.D., Malbecq, W., Meisner, D., Somers, G. Pharm. Res. (1996) [Pubmed]
A series of non-quinoline cysLT1 receptor antagonists: SAR study on pyridyl analogs of Singulair. Guay, D., Gauthier, J.Y., Dufresne, C., Jones, T.R., McAuliffe, M., McFarlane, C., Metters, K.M., Prasit, P., Rochette, C., Roy, P., Sawyer, N., Zamboni, R. Bioorg. Med. Chem. Lett. (1998) [Pubmed]
A novel photoaffinity probe for the LTD4 receptor. Gallant, M., Sawyer, N., Metters, K.M., Zamboni, R.J. Bioorg. Med. Chem. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share