The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

HMDB10216     (5S,6E,8Z,11Z,13E,15S)-5,15- dihydroxyicosa...

Synonyms: BML1-D01, LMFA03060010, AC1NR1NK, 5,15-Dihete, 5S,15S-DiHETE, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of AIDS-163835

 

Psychiatry related information on AIDS-163835

 

High impact information on AIDS-163835

  • When human neutrophils, prelabeled with [3H]arachidonic acid, were incubated with 5S,15S-dihydroxyeicosatetraenoic acid (5,15-diHETE), a dose-dependent increase in the 15-lipoxygenase product [3H]-15-HETE was observed relative to untreated cells [3].
  • In addition, 5,15-diHETE itself stimulated the inactive 5-lipoxygenase and eight times more [3H]diHETE was bound to cells than became incorporated into cellular lipids [4].
  • Purification of this ECL by high performance liquid chromatography revealed that ECL is structurally different from well known eosinophil chemotactic eicosanoids such as leukotriene B4, 5,15-(6E,8Z,11Z,13E)-dihydroxyeicosatetraenoic acid (5,15-diHETE), and (8S,15S)-(5Z,9E,11Z,13E)-dihydroxyeicosatetra eno ic acid ((8S,15S)-diHETE) [5].
  • Only 5,15-DiHETE as well as 8(S), 15(S)-dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic acid were found to be chemotaxins for human eosinophils, however, with an ED50 near 0.3 microM and 1.5 microM, respectively [6].
  • Similar, if not identical, tetraenes were produced by action of the keratinocyte enzyme on 5(S),15(S)-diHETE, which points to the role of the latter as an intermediate between 5-HETE and the tetraenes [7].
 

Associations of AIDS-163835 with other chemical compounds

 

Gene context of AIDS-163835

  • Reversed phase HPLC of incubation supernatants revealed major lipid-like eosinophil chemotactic activity eluting in a peak containing 5(S), 15(S)dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid (5,15-DiHETE) as well as a 8,15-dihydroxyeicosatetraenoic acid [6].
  • However, stimulation of neutrophils with PAF resulted in the transformation of the 15-hydroperoxy acid into the 5,15-diHETE, and furthermore, preincubation of neutrophils with GM-CSF resulted in enhanced formation of 5,15-diHETE in response to PAF [9].

References

  1. Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes. Maas, R.L., Turk, J., Oates, J.A., Brash, A.R. J. Biol. Chem. (1982) [Pubmed]
  2. Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis. Thomas, E., Leroux, J.L., Blotman, F., Chavis, C. Inflamm. Res. (1995) [Pubmed]
  3. 5-Hydroxyeicosanoids selectively stimulate the human neutrophil 15-lipoxygenase to use endogenous substrate. Nichols, R.C., Vanderhoek, J.Y. J. Exp. Med. (1990) [Pubmed]
  4. 15-Hydroxyeicosatetraenoic acid (15-HETE) receptors. Involvement in the 15-HETE-induced stimulation of the cryptic 5-lipoxygenase in PT-18 mast/basophil cells. Vonakis, B.M., Vanderhoek, J.Y. J. Biol. Chem. (1992) [Pubmed]
  5. Identification of 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid as a novel and potent human eosinophil chemotactic eicosanoid. Schwenk, U., Morita, E., Engel, R., Schröder, J.M. J. Biol. Chem. (1992) [Pubmed]
  6. Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid. Morita, E., Schröder, J.M., Christophers, E. J. Immunol. (1990) [Pubmed]
  7. Transformations of 5-HETE by activated keratinocyte 15-lipoxygenase and the activation mechanism. Green, F.A. Lipids (1990) [Pubmed]
  8. Metabolism of 5(S)-hydroxyeicosanoids by a specific dehydrogenase in human neutrophils. Powell, W.S., Gravelle, F., Gravel, S., Hashefi, M. Journal of lipid mediators. (1993) [Pubmed]
  9. Enhancement of platelet-activating factor-induced leukotriene synthesis in neutrophils by granulocyte-macrophage colony-stimulating factor (GM-CSF): studies on the mechanism of action of GM-CSF. McColl, S.R., Krump, E., McDonald, P.P., Braquet, M., Naccache, P.H., Borgeat, P. Journal of lipid mediators. (1990) [Pubmed]
 
WikiGenes - Universities