The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL18028     (6E,8Z,11Z,14Z)-5-oxoicosa- 6,8,11,14...

Synonyms: BSPBio_001453, CHEBI:52449, HMDB10217, BML1-D12, LMFA03060011, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 5-Oxo-ETE


High impact information on 5-Oxo-ETE

  • 5-Oxo-ETE induced a dramatic increase in the numbers of eosinophils (ED50, 2.5 microg) around the walls of the airways, which reached maximal levels (five times control levels) between 15 and 24 h after administration, and then declined [3].
  • 5-Oxo-ETE and leukotriene B(4) had similar effects on GM-CSF release at low concentrations, but 5-oxo-ETE induced a much stronger response at concentrations of 10 nm or higher [4].
  • 5-Oxo-ETE synthesis was also strongly stimulated by hydroperoxides in blood monocytes, lymphocytes, and platelets, but not neutrophils [5].
  • 5-Oxo-ETE (5-oxo-6,8,11,14-eicosatetraenoic acid) is a highly potent granulocyte chemoattractant that acts through a selective G-protein coupled receptor [5].
  • 5-Oxo-ETE (EC50, 10 nM) also rapidly stimulated actin polymerization in neutrophils, with a maximal response at 20 s [6].

Biological context of 5-Oxo-ETE


Anatomical context of 5-Oxo-ETE


Associations of 5-Oxo-ETE with other chemical compounds


Gene context of 5-Oxo-ETE


  1. Metabolism and biologic effects of 5-oxoeicosanoids on human neutrophils. Powell, W.S., MacLeod, R.J., Gravel, S., Gravelle, F., Bhakar, A. J. Immunol. (1996) [Pubmed]
  2. Eotaxin and RANTES enhance 5-oxo-6,8,11,14-eicosatetraenoic acid-induced eosinophil chemotaxis. Powell, W.S., Ahmed, S., Gravel, S., Rokach, J. J. Allergy Clin. Immunol. (2001) [Pubmed]
  3. 5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats. Stamatiou, P., Hamid, Q., Taha, R., Yu, W., Issekutz, T.B., Rokach, J., Khanapure, S.P., Powell, W.S. J. Clin. Invest. (1998) [Pubmed]
  4. 5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes. Stamatiou, P.B., Chan, C.C., Monneret, G., Ethier, D., Rokach, J., Powell, W.S. J. Biol. Chem. (2004) [Pubmed]
  5. Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells. Erlemann, K.R., Rokach, J., Powell, W.S. J. Biol. Chem. (2004) [Pubmed]
  6. Effects of 5-oxo-6,8,11,14-eicosatetraenoic acid on expression of CD11b, actin polymerization, and adherence in human neutrophils. Powell, W.S., Gravel, S., Halwani, F., Hii, C.S., Huang, Z.H., Tan, A.M., Ferrante, A. J. Immunol. (1997) [Pubmed]
  7. Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells. Erlemann, K.R., Cossette, C., Gravel, S., Stamatiou, P.B., Lee, G.J., Rokach, J., Powell, W.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  8. LTA(4)-derived 5-oxo-eicosatetraenoic acid: pH-dependent formation and interaction with the LTB(4) receptor of human polymorphonuclear leukocytes. Falgueyret, J., Riendeau, D. Biochim. Biophys. Acta (2000) [Pubmed]
  9. 5-Lipoxygenase products regulate basophil functions: 5-Oxo-ETE elicits migration, and leukotriene B(4) induces degranulation. Iikura, M., Suzukawa, M., Yamaguchi, M., Sekiya, T., Komiya, A., Yoshimura-Uchiyama, C., Nagase, H., Matsushima, K., Yamamoto, K., Hirai, K. J. Allergy Clin. Immunol. (2005) [Pubmed]
  10. 5-Oxo-ETE regulates tone of guinea pig airway smooth muscle via activation of Ca2+ pools and Rho-kinase pathway. Mercier, F., Morin, C., Cloutier, M., Proteau, S., Rokach, J., Powell, W.S., Rousseau, E. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  11. 5-Oxo-6,8,11,14-eicosatetraenoic acid stimulates isotonic volume reduction of guinea pig jejunal crypt epithelial cells. MacLeod, R.J., Lembessis, P., Hamilton, J.R., Powell, W.S. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  12. Trans-basement membrane migration of human basophils: role of matrix metalloproteinase-9. Suzukawa, M., Komiya, A., Iikura, M., Nagase, H., Yoshimura-Uchiyama, C., Yamada, H., Kawasaki, H., Ohta, K., Matsushima, K., Hirai, K., Yamamoto, K., Yamaguchi, M. Int. Immunol. (2006) [Pubmed]
  13. Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. Langlois, A., Ferland, C., Tremblay, G.M., Laviolette, M. J. Allergy Clin. Immunol. (2006) [Pubmed]
WikiGenes - Universities