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Chemical Compound Review

AC1NRBOB     [(1S)-1-hydroxy-3,7,11- trimethyl...

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Disease relevance of alpha-hydroxyfarnesylphosphonic acid


High impact information on alpha-hydroxyfarnesylphosphonic acid


Biological context of alpha-hydroxyfarnesylphosphonic acid


Anatomical context of alpha-hydroxyfarnesylphosphonic acid

  • Using primary cultures of ovine pulmonary arterial endothelial cells we demonstrated that the NO donor SpermineNONOate, increased p21ras activity by 2.3-fold compared to untreated cells, and that the farnesyl-transferase inhibitor, alpha-hydroxyfarnesylphosphonic acid, reduced p21ras activity and significantly reduced inhibition of eNOS [8].

Gene context of alpha-hydroxyfarnesylphosphonic acid


  1. Hyperinsulinemia potentiates activation of p21Ras by growth factors. Leitner, J.W., Kline, T., Carel, K., Goalstone, M., Draznin, B. Endocrinology (1997) [Pubmed]
  2. Insulin promotes phosphorylation and activation of geranylgeranyltransferase II. Studies with geranylgeranylation of rab-3 and rab-4. Goalstone, M.L., Leitner, J.W., Golovchenko, I., Stjernholm, M.R., Cormont, M., Le Marchand-Brustel, Y., Draznin, B. J. Biol. Chem. (1999) [Pubmed]
  3. Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor. Goalstone, M.L., Leitner, J.W., Wall, K., Dolgonos, L., Rother, K.I., Accili, D., Draznin, B. J. Biol. Chem. (1998) [Pubmed]
  4. Differential activation of mitogen-activated protein kinases by nitric oxide-related species. Lander, H.M., Jacovina, A.T., Davis, R.J., Tauras, J.M. J. Biol. Chem. (1996) [Pubmed]
  5. Farnesyl protein transferase: identification of K164 alpha and Y300 beta as catalytic residues by mutagenesis and kinetic studies. Wu, Z., Demma, M., Strickland, C.L., Radisky, E.S., Poulter, C.D., Le, H.V., Windsor, W.T. Biochemistry (1999) [Pubmed]
  6. Choline phosphate potentiates sphingosine-1-phosphate-induced Raf-1 kinase activation dependent of Ras--phosphatidylinositol-3-kinase pathway. Lee, M., Han, S.S. Cell. Signal. (2002) [Pubmed]
  7. Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase. Mau, C.J., Garneau, S., Scholte, A.A., Van Fleet, J.E., Vederas, J.C., Cornish, K. Eur. J. Biochem. (2003) [Pubmed]
  8. Nitric oxide activates p21ras and leads to the inhibition of endothelial NO synthase by protein nitration. Brennan, L.A., Wedgwood, S., Bekker, J.M., Black, S.M. DNA Cell Biol. (2003) [Pubmed]
  9. Raf-independent and MEKK1-dependent activation of NF-kappaB by hydrogen peroxide in 70Z/3 pre-B lymphocyte tumor cells. Lee, M., Koh, W.S. J. Cell. Biochem. (2003) [Pubmed]
  10. Role of G proteins and modulation of p38 MAPK activation in the protection by nitric oxide against ischemia-reoxygenation injury. Rakhit, R.D., Kabir, A.N., Mockridge, J.W., Saurin, A., Marber, M.S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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