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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Tiliroside     [(2R,3S,4S,5R,6S)-6-[5,7- dihydroxy-2-(4...

Synonyms: AC1NSZRJ, SureCN23597, CHEMBL266564, CHEBI:493090, MEGxp0_000169, ...
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High impact information on AIDS003029


Biological context of AIDS003029

  • Of these compounds, compound 2 exhibited potent anti-complement activity (IC50= 1.0 +/- 0.1 microM) on the classical pathway of the complement, as compared to tiliroside (IC50= 76.5 +/- 1.1 microM), which was used as a positive control [5].

Associations of AIDS003029 with other chemical compounds

  • It might be assumed that determined biological properties are due to the presence of (-)-epigallocatechin in the plant, although the flavonoids, kaempferol and tiliroside isolated from the leaves, could account for the antiprotozoal properties of this herbal resource, used in Mayan traditional medicine for the treatment of bloody diarrhoea [6].
  • In conclusion, tiliroside and gnaphaliin are antioxidants against in vitro Cu(2+)-induced LDL oxidation in the same order of magnitude compared to that of the reference drug, probucol [7].
  • A new natural C-benzylated chalcone, 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-6'-methoxychalcone (2), along with two other flavonoids, tiliroside and kaempferol 3-O-rutinoside, and an oxoaporphine alkaloid, lanuginosine were isolated from the aerial parts of Ellipeiopsis cherrevensis (Annonaceae) [8].
  • Platanoside (1) exhibited cytotoxic activity against most of the cell lines tested, while tiliroside (2) was active against two of the nine tested cell lines [9].


  1. Biotransformation of the flavonoid tiliroside to 7-methylether tiliroside: bioactivity of this metabolite and of its acetylated derivative. Demetzos, C., Magiatis, P., Typas, M.A., Dimas, K., Sotiriadou, R., Perez, S., Kokkinopoulos, D. Cell. Mol. Life Sci. (1997) [Pubmed]
  2. Assessment of the anti-inflammatory activity and free radical scavenger activity of tiliroside. Sala, A., Recio, M.C., Schinella, G.R., Máñez, S., Giner, R.M., Cerdá-Nicolás, M., Rosí, J.L. Eur. J. Pharmacol. (2003) [Pubmed]
  3. Cytotoxic and antiproliferative effects of heptaacetyltiliroside on human leukemic cell lines. Dimas, K., Demetzos, C., Vaos, B., Marselos, M., Kokkinopoulos, D. Leuk. Res. (1999) [Pubmed]
  4. Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum. Calzada, F., Alan??s, A.D. Phytotherapy research : PTR (2007) [Pubmed]
  5. A potent anti-complementary acylated sterol glucoside from Orostachys japonicus. Yoon, N.Y., Min, B.S., Lee, H.K., Park, J.C., Choi, J.S. Arch. Pharm. Res. (2005) [Pubmed]
  6. Antiprotozoal properties of Helianthemum glomeratum. Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. Phytotherapy research : PTR. (1999) [Pubmed]
  7. Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation. Schinella, G.R., Tournier, H.A., M????ez, S., de Buschiazzo, P.M., Del Carmen Recio, M., R??os, J.L. Fitoterapia (2007) [Pubmed]
  8. Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis. Wirasathien, L., Pengsuparp, T., Moriyasu, M., Kawanishi, K., Suttisri, R. Arch. Pharm. Res. (2006) [Pubmed]
  9. Cytotoxic activity of kaempferol glycosides against human leukaemic cell lines in vitro. Dimas, K., Demetzos, C., Mitaku, S., Marselos, M., Tzavaras, T., Kokkinopoulos, D. Pharmacol. Res. (2000) [Pubmed]
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