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Chemical Compound Review:

asragalin 5,7-dihydroxy-2-(4- hydroxyphenyl)-3-[(2S...

Synonyms: Astragalin, Astragaline, SureCN23897, AC1NQZH5, CHEMBL233930, ...

Jian, J. et al., Le Gall, G. et al., Calzada, F. et al., Ni, Z. et al., Doi, K. et al., et al.

Jian, Wu,

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Disease relevance of Kaempferol-3-beta-monoglucoside

Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice [1].

High impact information on Kaempferol-3-beta-monoglucoside

RESULTS: Persimmon leaf extract or astragalin inhibited histamine release from KU812 in response to cross-linkage of FcepsilonRI [1].
Three flavonoids, quercetin 3- O-glucoside-2''-gallate (QGG), quercetin 3- O-rhamnoside-2''-gallate (QRG) and kaempferol 3- O-glucoside-2''-gallate (KGG) were isolated from Japanese Polygonum species [2].
The influence of traditional Chinese medicine (TCM) formulation from Astragalus Root (Radix astragalin seu Hedysari) and Chinese Angelica Root (R. Angelicae Sinensis) at a ratio of 5:1 (w/w) on non-specific immunity of Jian carp, Cyprinus carpio var [3].
Parallel assays that measured thiobarbituric acid related substances confirm the antioxidant effects of KA and KG and explain the results of spin trapping experiments complicated by low pH's [4].
LC/NMR, LC/MS, and LC/MS/MS enabled us to identify these as kaempferol-3,7-di-O-glucoside (1), kaempferol-3-O-rutinoside-7-O-glucoside (2), two dihydrokaempferol-O-hexosides (3 and 4), rutin (5), kaempferol-3-O-rutinoside (6), kaempferol-3-O-glucoside (7), naringenin-7-O-glucoside (8) and naringenin chalcone (9), which were quantified by HPLC/DAD [5].

Biological context of Kaempferol-3-beta-monoglucoside

CONCLUSIONS: Astragalin inhibits cell proliferation and matrix over-synthesis which might be mediated, at least, partly by decrease of beta 1 integrin gene over-expression [6].

Anatomical context of Kaempferol-3-beta-monoglucoside

OBJECTIVE: To investigate the effect of Astragalin on human renal mesangial cells [6].

Associations of Kaempferol-3-beta-monoglucoside with other chemical compounds

Two novel prenylflavanes (1, 2) and a glycoside (3) of 1 were isolated along with six known compounds, isoquercitrin (4), astragalin (5), scopolin (6), skimmin (7), roseoside II (8) and benzyl D-glucopyranoside (9), from the leaves of Morus alba [7].
Bioassay-guided fractionation of the methanol extract of aerial parts from Helianthemum glomeratum afforded five antiprotozoal flavonol glycosides: tiliroside, kaempferol-3-O-(3'',6''di-O-E-p-coumaroyl)-betad-glucopyranoside, astragalin, quercitrin and isoquercitrin [8].

Analytical, diagnostic and therapeutic context of Kaempferol-3-beta-monoglucoside

RESULTS: Oral administration of persimmon leaf extract (250 mg kg(-1)) or astragalin (1.5 mg kg-1) for 4 weeks into NC/Nga mice with overt dermatitis resulted in a decrease in the severity of the condition [9].

References

Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice. Kotani, M., Matsumoto, M., Fujita, A., Higa, S., Wang, W., Suemura, M., Kishimoto, T., Tanaka, T. J. Allergy Clin. Immunol. (2000) [Pubmed]
Effect of three flavonoids isolated from Japanese Polygonum species on superoxide generation in human neutrophils. Liu, G., Wang, W., Masuoka, N., Isobe, T., Yamashita, K., Manabe, M., Kodama, H. Planta Med. (2005) [Pubmed]
Influences of traditional Chinese medicine on non-specific immunity of Jian Carp (Cyprinus carpio var. Jian). Jian, J., Wu, Z. Fish Shellfish Immunol. (2004) [Pubmed]
Antioxidant activity of Sempervivum tectorum and its components. Sentjurc, M., Nemec, M., Connor, H.D., Abram, V. J. Agric. Food Chem. (2003) [Pubmed]
Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits. Le Gall, G., DuPont, M.S., Mellon, F.A., Davis, A.L., Collins, G.J., Verhoeyen, M.E., Colquhoun, I.J. J. Agric. Food Chem. (2003) [Pubmed]
Effect of Astragalin on matrix secretion and beta 1 integrin mRNA expression in human mesangial cells. Ni, Z., Zhang, Q., Qian, J., Wang, L. Chin. Med. J. (1999) [Pubmed]
Studies on the constituents of the leaves of Morus alba L. Doi, K., Kojima, T., Makino, M., Kimura, Y., Fujimoto, Y. Chem. Pharm. Bull. (2001) [Pubmed]
Additional antiprotozoal flavonol glycosides of the aerial parts of Helianthemum glomeratum. Calzada, F., Alan??s, A.D. Phytotherapy research : PTR (2007) [Pubmed]
Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Matsumoto, M., Kotani, M., Fujita, A., Higa, S., Kishimoto, T., Suemura, M., Tanaka, T. Br. J. Dermatol. (2002) [Pubmed]

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