Chemical Compound Review:
Lurselle 4-[2-(4-hydroxy-3,5-ditert- butyl...
Synonyms:
probucol, Lorelco, Panavir, Biphenabid, Superlipid, ...
- Polymorphic ventricular tachycardia (Torsade de Pointes) associated with the use of probucol. Gohn, D.C., Simmons, T.W. N. Engl. J. Med. (1992)
- Probucol (Lorelco) in treatment of hyperlipemia. Murphy, B.F. JAMA (1977)
- A comparison of the antiatherogenic effects of probucol and of a structural analogue of probucol in low density lipoprotein receptor-deficient rabbits. Fruebis, J., Steinberg, D., Dresel, H.A., Carew, T.E. J. Clin. Invest. (1994)
- Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. Neale, T.J., Ojha, P.P., Exner, M., Poczewski, H., Rüger, B., Witztum, J.L., Davis, P., Kerjaschki, D. J. Clin. Invest. (1994)
- Ischemic acute renal failure and antioxidant therapy in the rat. The relation between glomerular and tubular dysfunction. Bird, J.E., Milhoan, K., Wilson, C.B., Young, S.G., Mundy, C.A., Parthasarathy, S., Blantz, R.C. J. Clin. Invest. (1988)
- Dietary phytosterols reduce probucol-induced atherogenesis in apo E-KO mice. Moghadasian, M.H. Atherosclerosis (2006)
- The cholesterol-lowering drug probucol increases apolipoprotein E production in the hippocampus of aged rats: implications for Alzheimer's disease. Champagne, D., Pearson, D., Dea, D., Rochford, J., Poirier, J. Neuroscience (2003)
- Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Multivitamins and Probucol Study Group. Tardif, J.C., Cöté, G., Lespérance, J., Bourassa, M., Lambert, J., Doucet, S., Bilodeau, L., Nattel, S., de Guise, P. N. Engl. J. Med. (1997)
- Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. Wu, B.J., Kathir, K., Witting, P.K., Beck, K., Choy, K., Li, C., Croft, K.D., Mori, T.A., Tanous, D., Adams, M.R., Lau, A.K., Stocker, R. J. Exp. Med. (2006)
- Abnormally high thromboxane biosynthesis in homozygous homocystinuria. Evidence for platelet involvement and probucol-sensitive mechanism. Di Minno, G., Davì, G., Margaglione, M., Cirillo, F., Grandone, E., Ciabattoni, G., Catalano, I., Strisciuglio, P., Andria, G., Patrono, C. J. Clin. Invest. (1993)
- Propranolol for probucol-induced QT prolongation with polymorphic ventricular tachycardia. Kajinami, K., Takekoshi, N., Mabuchi, H. Lancet (1993)
- Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis. Glueck, C.J. Ann. Intern. Med. (1982)
- Probucol with colestipol in the treatment of hypercholesterolemia. Dujovne, C.A., Krehbiel, P., Decoursey, S., Jackson, B., Chernoff, S.B., Pitterman, A., Garty, M. Ann. Intern. Med. (1984)
- Antioxidants improve impaired insulin-mediated glucose uptake and prevent migration and proliferation of cultured rabbit coronary smooth muscle cells induced by high glucose. Yasunari, K., Kohno, M., Kano, H., Yokokawa, K., Minami, M., Yoshikawa, J. Circulation (1999)
- Dissociation of atherogenesis from aortic accumulation of lipid hydro(pero)xides in Watanabe heritable hyperlipidemic rabbits. Witting, P., Pettersson, K., Ostlund-Lindqvist, A.M., Westerlund, C., Wâgberg, M., Stocker, R. J. Clin. Invest. (1999)
- Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. Keaney, J.F., Xu, A., Cunningham, D., Jackson, T., Frei, B., Vita, J.A. J. Clin. Invest. (1995)
- Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol. Kaplan, R., Aynedjian, H.S., Schlondorff, D., Bank, N. J. Clin. Invest. (1990)
- Probucol inhibits oxidative modification of low density lipoprotein. Parthasarathy, S., Young, S.G., Witztum, J.L., Pittman, R.C., Steinberg, D. J. Clin. Invest. (1986)
- Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? Sasahara, M., Raines, E.W., Chait, A., Carew, T.E., Steinberg, D., Wahl, P.W., Ross, R. J. Clin. Invest. (1994)
- Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein. Navab, M., Imes, S.S., Hama, S.Y., Hough, G.P., Ross, L.A., Bork, R.W., Valente, A.J., Berliner, J.A., Drinkwater, D.C., Laks, H. J. Clin. Invest. (1991)
- Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice. Zhang, S.H., Reddick, R.L., Avdievich, E., Surles, L.K., Jones, R.G., Reynolds, J.B., Quarfordt, S.H., Maeda, N. J. Clin. Invest. (1997)
- Restenosis: a challenge for pharmacology. Bult, H. Trends Pharmacol. Sci. (2000)
- Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. Wu, C.A., Tsujita, M., Hayashi, M., Yokoyama, S. J. Biol. Chem. (2004)
- Probucol promotes reverse cholesterol transport in heterozygous familial hypercholesterolemia. Effects on apolipoprotein AI-containing lipoprotein particles. Adlouni, A., El Messal, M., Saïle, R., Parra, H., Fruchart, J., Ghalim, N. Atherosclerosis (2000)
- Regulation of mitochondrial transcription factor A expression by high glucose. Choi, Y.S., Lee, K.U., Pak, Y.K. Ann. N. Y. Acad. Sci. (2004)
- Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice: possible mechanisms of action. Moghadasian, M.H., McManus, B.M., Godin, D.V., Rodrigues, B., Frohlich, J.J. Circulation (1999)
- Probucol and multivitamins in the prevention of restenosis after coronary angioplasty. Sirtori, C.R., Franceschini, G. N. Engl. J. Med. (1997)
- Probucol decreases neointimal formation in a swine model of coronary artery balloon injury. A possible role for antioxidants in restenosis. Schneider, J.E., Berk, B.C., Gravanis, M.B., Santoian, E.C., Cipolla, G.D., Tarazona, N., Lassegue, B., King, S.B. Circulation (1993)
- Effects of probucol on vascular remodeling after coronary angioplasty. Multivitamins and Protocol Study Group. Côté, G., Tardif, J.C., Lespérance, J., Lambert, J., Bourassa, M., Bonan, R., Gosselin, G., Joyal, M., Tanguay, J.F., Nattel, S., Gallo, R., Crépeau, J. Circulation (1999)