Chemical Compound Review:
CHEMBL2062137 (2S)-1-[(2S,4S)-2-hydroxy-4- [[(1R,2R)-2...
Synonyms:
AKOS016007841, AC1L4BH9, AK105055, L-754394, L-754,394, ...
- Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394. Lightning, L.K., Jones, J.P., Friedberg, T., Pritchard, M.P., Shou, M., Rushmore, T.H., Trager, W.F. Biochemistry (2000)
- Time- and dose-dependent pharmacokinetics of L-754,394, an HIV protease inhibitor, in rats, dogs and monkeys. Lin, J.H., Chiba, M., Chen, I.W., Vastag, K.J., Nishime, J.A., Dorsey, B.D., Michelson, S.R., McDaniel, S.L. J. Pharmacol. Exp. Ther. (1995)
- In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4. Sahali-Sahly, Y., Balani, S.K., Lin, J.H., Baillie, T.A. Chem. Res. Toxicol. (1996)
- Route-dependent nonlinear pharmacokinetics of a novel HIV protease inhibitor: involvement of enzyme inactivation. Lin, J.H., Chen, I.W., Chiba, M., Nishime, J.A., Deluna, F.A. Drug Metab. Dispos. (2000)
- Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4. Achira, M., Suzuki, H., Ito, K., Sugiyama, Y. AAPS PharmSci (1999)
- Potent and selective inactivation of human liver microsomal cytochrome P-450 isoforms by L-754,394, an investigational human immune deficiency virus protease inhibitor. Chiba, M., Nishime, J.A., Lin, J.H. J. Pharmacol. Exp. Ther. (1995)