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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NUPI0     (6E)-6-[[1-(3H-imidazol-4- yl)propan-2...

Synonyms: SureCN1648788, BP-2-94, BP 2-94, L001548, 139191-80-3
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Disease relevance of BP-2-94

  • Repeated oral administrations of BP 2-94 reduced the pre-established Freund's complete adjuvant-induced edema with an ED(50) value of 5 +/- 2 micromol/kg (p.o.) and a maximal effect of 47% [1].
  • From its pharmacokinetics and pharmacological profile BP 2-94 appears to be a promising novel therapeutic agent in disorders such as asthma, migraine or a variety of inflammatory diseases and pain associated with these disorders [2].
  • CONCLUSIONS: BP 2-94 had a hepatoprotective effect in a model of CCl4-induced toxicity in rats [3].

High impact information on BP-2-94


Biological context of BP-2-94


Anatomical context of BP-2-94


Associations of BP-2-94 with other chemical compounds


Analytical, diagnostic and therapeutic context of BP-2-94

  • In mice after oral administration of BP 2-94 high levels of both prodrug and (R)alpha-MeHA were detected in plasma and various tissues except in the brain [2].


  1. Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. Rouleau, A., Stark, H., Schunack, W., Schwartz, J.C. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  2. Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. Rouleau, A., Garbarg, M., Ligneau, X., Mantion, C., Lavie, P., Advenier, C., Lecomte, J.M., Krause, M., Stark, H., Schunack, W., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  3. Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats. Valcheva-Kuzmanova, S.V., Popova, P.B., Krasnaliev, I.J., Galunska, B.T., Belcheva, A., Schunack, W. Folia medica. (2004) [Pubmed]
  4. Gastric antisecretory effects of compound BP 2-94: a histamine H3-receptor agonist prodrug. Soldani, G., Bertini, S., Rouleau, A., Schwartz, J.C., Coruzzi, G. Dig. Dis. Sci. (1999) [Pubmed]
  5. Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp. Boucher, Y., Hofman, S., Joulin, Y., Azérad, J. Arch. Oral Biol. (2001) [Pubmed]
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