Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NUPI0 (6E)-6-[[1-(3H-imidazol-4- yl)propan-2...

Synonyms: SureCN1648788, BP-2-94, BP 2-94, L001548, 139191-80-3

Rouleau, A. et al., Soldani, G. et al., Valcheva-Kuzmanova, S.V. et al., Rouleau, A. et al., Boucher, Y. et al.

Boucher, Hofman, Joulin, Azérad, Rouleau, Stark, Schunack, Schwartz,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BP-2-94

Repeated oral administrations of BP 2-94 reduced the pre-established Freund's complete adjuvant-induced edema with an ED(50) value of 5 +/- 2 micromol/kg (p.o.) and a maximal effect of 47% [1].
From its pharmacokinetics and pharmacological profile BP 2-94 appears to be a promising novel therapeutic agent in disorders such as asthma, migraine or a variety of inflammatory diseases and pain associated with these disorders [2].
CONCLUSIONS: BP 2-94 had a hepatoprotective effect in a model of CCl4-induced toxicity in rats [3].

High impact information on BP-2-94

Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug [2].
A sensitive radioimmunoassay was developed to study the generation of (R)alpha-MeHA slowly released from BP 2-94 in vitro and in vivo by chemical hydrolysis [2].
The effects of BP 2-94 on gastric acid secretion and on histamine, gastrin, and somatostatin release were also investigated [4].
Gastric antisecretory effects of compound BP 2-94: a histamine H3-receptor agonist prodrug [4].
The increase in plasma gastrin levels induced by 2-deoxy-D-glucose, bombesin or a test meal was not significantly modified by BP 2-94 (30 mg/kg, intragastrically) [4].

Biological context of BP-2-94

Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp [5].

Anatomical context of BP-2-94

In anesthetized dogs BP 2-94 (30 mg/kg, intragastrically) significantly reduced histamine release detected in the portal vein under bombesin infusion, whereas it did not modify gastrin and somatostatin plasma levels [4].

Associations of BP-2-94 with other chemical compounds

Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats [3].

Analytical, diagnostic and therapeutic context of BP-2-94

In mice after oral administration of BP 2-94 high levels of both prodrug and (R)alpha-MeHA were detected in plasma and various tissues except in the brain [2].

References

Anti-inflammatory and antinociceptive properties of BP 2-94, a histamine H(3)-receptor agonist prodrug. Rouleau, A., Stark, H., Schunack, W., Schwartz, J.C. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. Rouleau, A., Garbarg, M., Ligneau, X., Mantion, C., Lavie, P., Advenier, C., Lecomte, J.M., Krause, M., Stark, H., Schunack, W., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
Protective effect of BP 2-94, a histamine H3-receptor agonist prodrug, in a model of carbon tetrachloride-induced hepatotoxicity in rats. Valcheva-Kuzmanova, S.V., Popova, P.B., Krasnaliev, I.J., Galunska, B.T., Belcheva, A., Schunack, W. Folia medica. (2004) [Pubmed]
Gastric antisecretory effects of compound BP 2-94: a histamine H3-receptor agonist prodrug. Soldani, G., Bertini, S., Rouleau, A., Schwartz, J.C., Coruzzi, G. Dig. Dis. Sci. (1999) [Pubmed]
Effects of BP 2-94, a selective H(3)-receptor agonist, on blood flow and vascular permeability of the rat mandibular incisor pulp. Boucher, Y., Hofman, S., Joulin, Y., Azérad, J. Arch. Oral Biol. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.