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Gene Review

Hrh3  -  histamine receptor H3

Rattus norvegicus

Synonyms: H3R, HH3R, Histamine H3 receptor
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Disease relevance of Hrh3


Psychiatry related information on Hrh3


High impact information on Hrh3


Chemical compound and disease context of Hrh3


Biological context of Hrh3


Anatomical context of Hrh3


Associations of Hrh3 with chemical compounds


Regulatory relationships of Hrh3

  • Whether or not neuropeptide Y (NPY)-induced feeding in rats is influenced by the histaminergic system in the brain was investigated by intracerebroventricular (i.c.v.) administration of a selective histamine H3 receptor antagonist prior to i.c.v. administration of NPY [28].

Other interactions of Hrh3


Analytical, diagnostic and therapeutic context of Hrh3


  1. Histamine H3 receptor-mediated inhibition of sympathetically evoked mydriasis in rats. Yu, Y., Kawarai, M., Koss, M.C. Eur. J. Pharmacol. (2001) [Pubmed]
  2. Regulation of substance P release mediated via prejunctional histamine H3 receptors. Ohkubo, T., Shibata, M., Inoue, M., Kaya, H., Takahashi, H. Eur. J. Pharmacol. (1995) [Pubmed]
  3. Relationship between histamine receptors in the brain and diazepam-induced hyperphagia in rats. Naruse, T., Ishii, R. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  4. Sensitivity of histamine H3 receptor agonist-stimulated [35S]GTP gamma[S] binding to pertussis toxin. Clark, E.A., Hill, S.J. Eur. J. Pharmacol. (1996) [Pubmed]
  5. Effect of BP 2.94, a histamine H3-receptor agonist prodrug, on different models of colitis. Coruzzi, G., Poli, E., Pozzoli, C., Nosalova, V., Grandi, D., Lazzaretti, M., Schunack, W. Inflamm. Res. (2002) [Pubmed]
  6. Effects of histamine H3 receptor ligands in experimental models of anxiety and depression. Pérez-García, C., Morales, L., Cano, M.V., Sancho, I., Alguacil, L.F. Psychopharmacology (Berl.) (1999) [Pubmed]
  7. Effects of selective activation or blockade of the histamine H3 receptor on sleep and wakefulness. Monti, J.M., Jantos, H., Boussard, M., Altier, H., Orellana, C., Olivera, S. Eur. J. Pharmacol. (1991) [Pubmed]
  8. Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. Giovannini, M.G., Bartolini, L., Bacciottini, L., Greco, L., Blandina, P. Behav. Brain Res. (1999) [Pubmed]
  9. Effect of histamine H3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats. Chen, Z. Acta Pharmacol. Sin. (2000) [Pubmed]
  10. Thioperamide, a histamine H3 receptor antagonist, powerfully suppresses peptide YY-induced food intake in rats. Itoh, E., Fujimiya, M., Inui, A. Biol. Psychiatry (1999) [Pubmed]
  11. Histamine h3 receptor antagonists potentiate methamphetamine self-administration and methamphetamine-induced accumbal dopamine release. Munzar, P., Tanda, G., Justinova, Z., Goldberg, S.R. Neuropsychopharmacology (2004) [Pubmed]
  12. Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure. Kazuta, Y., Hirano, K., Natsume, K., Yamada, S., Kimura, R., Matsumoto, S., Furuichi, K., Matsuda, A., Shuto, S. J. Med. Chem. (2003) [Pubmed]
  13. Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. Sasse, A., Kiec-Kononowicz, K., Stark, H., Motyl, M., Reidemeister, S., Ganellin, C.R., Ligneau, X., Schwartz, J.C., Schunack, W. J. Med. Chem. (1999) [Pubmed]
  14. Histamine H3 receptors modulate reactive hyperemia in rat gut. Pawlik, W.W., Obuchowicz, R., Pawlik, M.W., Sendur, R., Biernat, J., Brzozowski, T., Konturek, S.J. J. Physiol. Pharmacol. (2004) [Pubmed]
  15. Histamine H3 receptor-mediated depression of synaptic transmission in the dentate gyrus of the rat in vitro. Brown, R.E., Reymann, K.G. J. Physiol. (Lond.) (1996) [Pubmed]
  16. Histamine H3 receptor-mediated modulation of water consumption in the rat. Clapham, J., Kilpatrick, G.J. Eur. J. Pharmacol. (1993) [Pubmed]
  17. Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. De Esch, I.J., Vollinga, R.C., Goubitz, K., Schenk, H., Appelberg, U., Hacksell, U., Lemstra, S., Zuiderveld, O.P., Hoffmann, M., Leurs, R., Menge, W.M., Timmerman, H. J. Med. Chem. (1999) [Pubmed]
  18. Design, synthesis, and structure-activity relationships of acetylene-based histamine H3 receptor antagonists. Ali, S.M., Tedford, C.E., Gregory, R., Handley, M.K., Yates, S.L., Hirth, W.W., Phillips, J.G. J. Med. Chem. (1999) [Pubmed]
  19. Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives. Kovalainen, J.T., Christiaans, J.A., Kotisaari, S., Laitinen, J.T., Männistö, P.T., Tuomisto, L., Gynther, J. J. Med. Chem. (1999) [Pubmed]
  20. Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, [125I]-iodophenpropit, to rat brain. Jansen, F.P., Wu, T.S., Voss, H.P., Steinbusch, H.W., Vollinga, R.C., Rademaker, B., Bast, A., Timmerman, H. Br. J. Pharmacol. (1994) [Pubmed]
  21. Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat. Lozada, A.F., Aarnisalo, A.A., Karlstedt, K., Stark, H., Panula, P. BMC neuroscience [electronic resource]. (2004) [Pubmed]
  22. 4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity. Krause, M., Ligneau, X., Stark, H., Garbarg, M., Schwartz, J.C., Schunack, W. J. Med. Chem. (1998) [Pubmed]
  23. [3H]-thioperamide as a radioligand for the histamine H3 receptor in rat cerebral cortex. Alves-Rodrigues, A., Leurs, R., Wu, T.S., Prell, G.D., Foged, C., Timmerman, H. Br. J. Pharmacol. (1996) [Pubmed]
  24. Histamine H3-receptor blockade in the rat nucleus basalis magnocellularis improves place recognition memory. Orsetti, M., Ferretti, C., Gamalero, R., Ghi, P. Psychopharmacology (Berl.) (2002) [Pubmed]
  25. Histamine receptor subtypes mediating hyperpolarization in the isolated, perfused rat mesenteric pre-arteriolar bed. Adeagbo, A.S., Oriowo, M.A. Eur. J. Pharmacol. (1998) [Pubmed]
  26. Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity. Stark, H., Purand, K., Ligneau, X., Rouleau, A., Arrang, J.M., Garbarg, M., Schwartz, J.C., Schunack, W. J. Med. Chem. (1996) [Pubmed]
  27. Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats. Blandina, P., Giorgetti, M., Bartolini, L., Cecchi, M., Timmerman, H., Leurs, R., Pepeu, G., Giovannini, M.G. Br. J. Pharmacol. (1996) [Pubmed]
  28. Thioperamide, a histamine H3 receptor antagonist, suppresses NPY-but not dynorphin A-induced feeding in rats. Itoh, E., Fujimiya, M., Inui, A. Regul. Pept. (1998) [Pubmed]
  29. Effect of interleukin-1beta on the ascending and descending reflex in rat small intestine. Hahn, A., Huber, A., Neumayer, N., Allescher, H.D. Eur. J. Pharmacol. (1998) [Pubmed]
  30. Involvement of presynaptic histamine H3 receptors in the modulation of somatostatin binding and its effects on adenylyl cyclase activity in the rat frontoparietal cortex. Puebla, L., Arilla, E. J. Neurochem. (1996) [Pubmed]
  31. The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat. Baldi, E., Bucherelli, C., Schunack, W., Cenni, G., Blandina, P., Passani, M.B. Neuropharmacology (2005) [Pubmed]
  32. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Allen, M.C. Eur. J. Pharmacol. (1998) [Pubmed]
  33. Guanosine 5'-(gamma-[35S]thio)triphosphate autoradiography allows selective detection of histamine H3 receptor-dependent G protein activation in rat brain tissue sections. Laitinen, J.T., Jokinen, M. J. Neurochem. (1998) [Pubmed]
  34. Bioavailability, antinociceptive and antiinflammatory properties of BP 2-94, a histamine H3 receptor agonist prodrug. Rouleau, A., Garbarg, M., Ligneau, X., Mantion, C., Lavie, P., Advenier, C., Lecomte, J.M., Krause, M., Stark, H., Schunack, W., Schwartz, J.C. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  35. In vivo modulation of rat hypothalamic histamine release by the histamine H3 receptor ligands, immepip and clobenpropit. Effects of intrahypothalamic and peripheral application. Jansen, F.P., Mochizuki, T., Yamamoto, Y., Timmerman, H., Yamatodani, A. Eur. J. Pharmacol. (1998) [Pubmed]
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