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Chemical Compound Review:

PLUTONIUM-238 plutonium

Synonyms: AC1L1VRV, 238Pu, 13981-16-3, Plutonium, isotope of mass 238

Griffiths, S.D. et al., Riches, A.C. et al., Stradling, G.N. et al., Nagasawa, H. et al., Robertson, J.B. et al., et al.

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Disease relevance of plutonium

Primary bone neoplasms in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide [1].
Human thyroid carcinomas have been induced following exposure of SV40-immortalized human thyroid epithelial cells in vitro to single doses (0.14 Gy to 1.57 Gy) of 3.26 MeV alpha-particles from a plutonium 238 source [2].

High impact information on plutonium

We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation [3].
The induction of sister chromatid exchanges (SCE) was examined in Chinese hamster ovary cells irradiated in the G1 phase of the cell cycle with alpha-particles from a plutonium-238 source [4].
Primary liver tumors in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide [5].
Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particles [6].
Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells [7].

Anatomical context of plutonium

Oncogenic transformation of mouse BALB/3T3 cells by plutonium-238 alpha particles [8].
Sudden reversion to normal radiosensitivity to the effects of x irradiation and plutonium-238 alpha particles by a radioresistant rat-mouse hybrid cell line [9].
Induction of sister chromatid exchanges (SCE) in G0 lymphocytes by plutonium-238 alpha-particles [10].
Uptake and clearance of plutonium-238 from liver cells transplanted into fat pads of F344 rats [11].

Associations of plutonium with other chemical compounds

Enhanced killing of Chinese hamster cells by alpha-irradiation from plutonium-238 in the presence of cordycepin [12].
In blood, 0.001 micrometer diameter plutonium-238 oxide particles undergo a rapid reaction to form a low molecular weight species before plutonium is complexed with transferrin and citrate ions [13].

References

Primary bone neoplasms in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide. Hahn, F.F., Mewhinney, J.A., Merickel, B.S., Guilmette, R.A., Boecker, B.B., McClellan, R.O. J. Natl. Cancer Inst. (1981) [Pubmed]
Radiation-induced transformation of SV40-immortalized human thyroid epithelial cells by single exposure to plutonium alpha-particles in vitro. Riches, A.C., Herceg, Z., Bryant, P.E., Stevens, D.L., Goodhead, D.T. Int. J. Radiat. Biol. (1997) [Pubmed]
Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis. Griffiths, S.D., Goodhead, D.T., Marsden, S.J., Wright, E.G., Krajewski, S., Reed, J.C., Korsmeyer, S.J., Greaves, M. J. Exp. Med. (1994) [Pubmed]
Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Nagasawa, H., Little, J.B. Cancer Res. (1992) [Pubmed]
Primary liver tumors in beagle dogs exposed by inhalation to aerosols of plutonium-238 dioxide. Gillett, N.A., Muggenburg, B.A., Mewhinney, J.A., Hahn, F.F., Seiler, F.A., Boecker, B.B., McClellan, R.O. Am. J. Pathol. (1988) [Pubmed]
Bound PCNA in nuclei of primary rat tracheal epithelial cells after exposure to very low doses of plutonium-238 alpha particles. Hill, M.A., Ford, J.R., Clapham, P., Marsden, S.J., Stevens, D.L., Townsend, K.M., Goodhead, D.T. Radiat. Res. (2005) [Pubmed]
Cytogenetic effects of extremely low doses of plutonium-238 alpha-particle irradiation in CHO K-1 cells. Nagasawa, H., Little, J.B., Inkret, W.C., Carpenter, S., Thompson, K., Raju, M.R., Chen, D.J., Strniste, G.F. Mutat. Res. (1990) [Pubmed]
Oncogenic transformation of mouse BALB/3T3 cells by plutonium-238 alpha particles. Robertson, J.B., Koehler, A., George, J., Little, J.B. Radiat. Res. (1983) [Pubmed]
Sudden reversion to normal radiosensitivity to the effects of x irradiation and plutonium-238 alpha particles by a radioresistant rat-mouse hybrid cell line. Robertson, J.B., Raju, M.R. Radiat. Res. (1980) [Pubmed]
Induction of sister chromatid exchanges (SCE) in G0 lymphocytes by plutonium-238 alpha-particles. Aghamohammadi, S.Z., Goodhead, D.T., Savage, J.R. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1988) [Pubmed]
Uptake and clearance of plutonium-238 from liver cells transplanted into fat pads of F344 rats. Brooks, A.L., Guilmette, R.A., Hahn, F.F., Jirtle, R.L. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1986) [Pubmed]
Enhanced killing of Chinese hamster cells by alpha-irradiation from plutonium-238 in the presence of cordycepin. Robertson, J.B., Bain, E., Raju, M.R. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1980) [Pubmed]
Factors affecting the mobility of plutonium-238 dioxide in the rat. Stradling, G.N., Ham, G.J., Smith, H., Cooper, J., Breadmore, S.E. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. (1978) [Pubmed]

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