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Chemical Compound Review

Gaviscon     magnesium; sodium; aluminum(+3) cation;...

Synonyms: Gastrocote, Quigel, LS-186695, AC1O3SV3, 66220-44-8, ...
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Disease relevance of Alginic acid compound

  • Liquid Gaviscon suppressed gastro-oesophageal reflux of both food and acid whereas only an insignificant reduction in reflux was seen after Algicon Suspension [1].
  • Indeed, clinical studies have shown Gaviscon is superior to placebo, and equal to or significantly better than traditional antacids for relieving heartburn symptoms [2].
  • An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote') [3].
  • Severe hypokalaemic metabolic alkalosis following ingestion of gaviscon [4].
  • A multicentric, randomized clinical trial of Gaviscon in reflux esophagitis [5].

Psychiatry related information on Alginic acid compound

  • There was a clear trend towards improvement of endoscopic oesophagitis at ten weeks in the combined therapy group when compared to single agent treatment with cimetidine or Gastrocote although the difference was not significant due to inadequate numbers [6].

High impact information on Alginic acid compound


Chemical compound and disease context of Alginic acid compound


Anatomical context of Alginic acid compound

  • The validity and clinical acceptance of an alginic acid-containing agent, Gaviscon, which through a foaming action delivers a minimal dose of antacid directly at the site of acid irritation of the esophageal mucosa, has been confirmed in a multicentric, well-controlled randomized clinical trial [5].

Associations of Alginic acid compound with other chemical compounds


Analytical, diagnostic and therapeutic context of Alginic acid compound


  1. A comparison of gastro-oesophageal reflux in volunteers assessed by ambulatory pH and gamma monitoring after treatment with either Liquid Gaviscon or Algicon Suspension. Washington, N., Greaves, J.L., Iftikhar, S.Y. Aliment. Pharmacol. Ther. (1992) [Pubmed]
  2. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Mandel, K.G., Daggy, B.P., Brodie, D.A., Jacoby, H.I. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  3. Treatment of moderate to severe gastro-oesophageal reflux with an alginate/antacid combination. Hasan, S.S. Current medical research and opinion. (1980) [Pubmed]
  4. Severe hypokalaemic metabolic alkalosis following ingestion of gaviscon. Gawarammana, I.B., Coburn, J., Greene, S., Dargan, P.I., Jones, A.L. Clinical toxicology (Philadelphia, Pa.) (2007) [Pubmed]
  5. A multicentric, randomized clinical trial of Gaviscon in reflux esophagitis. McHardy, G. South. Med. J. (1978) [Pubmed]
  6. Combined cimetidine-alginate antacid therapy versus single agent treatment for reflux oesophagitis: results of prospective double-blind randomised clinical trial. Eriksen, C.A., Cheadle, W.G., Cranford, C.A., Cuschieri, A. Annales chirurgiae et gynaecologiae. (1988) [Pubmed]
  7. The mode of action alginic acid compound in the reduction of gastroesophageal reflux. Malmud, L.S., Charkes, N.D., Littlefield, J., Reilley, J., Stern, H., Rosenberg, R., Fisher, R.S. J. Nucl. Med. (1979) [Pubmed]
  8. Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo. Marciani, L., Little, S.L., Snee, J., Coleman, N.S., Tyler, D.J., Sykes, J., Jolliffe, I.G., Dettmar, P.W., Spiller, R.C., Gowland, P.A. J. Pharm. Pharmacol. (2002) [Pubmed]
  9. Gastro-oesophageal reflux in infants. Evaluation of treatment by pH monitoring. Vandenplas, Y., Sacré-Smits, L. Eur. J. Pediatr. (1987) [Pubmed]
  10. Cisapride treatment for gastro-oesophageal reflux in children. Augood, C., MacLennan, S., Gilbert, R., Logan, S. Cochrane database of systematic reviews (Online) (2003) [Pubmed]
  11. Gaviscon bezoars. Sorbie, A.L., Symon, D.N., Stockdale, E.J. Arch. Dis. Child. (1984) [Pubmed]
  12. A comparison of the efficacy of the alginate preparation, Gaviscon Advance, with placebo in the treatment of gastro-oesophageal reflux disease. Chatfield, S. Current medical research and opinion. (1999) [Pubmed]
  13. A comparative crossover study on the treatment of heartburn and epigastric pain: Liquid Gaviscon and a magnesium--aluminium antacid gel. Chevrel, B. J. Int. Med. Res. (1980) [Pubmed]
  14. Controlled trial of a new dosage form of carbenoxolone (Pyrogastrone) in the treatment of reflux esophagitis. Reed, P.I., Davies, W.A. The American journal of digestive diseases. (1978) [Pubmed]
  15. The effects of gaviscon and metoclopramide in gastroesophageal reflux in children. Forbes, D., Hodgson, M., Hill, R. J. Pediatr. Gastroenterol. Nutr. (1986) [Pubmed]
  16. In-vivo anti-reflux and raft properties of alginates. Lambert, J.R., Korman, M.G., Nicholson, L., Chan, J.G. Aliment. Pharmacol. Ther. (1990) [Pubmed]
  17. Clinical and laboratory studies of the antacid and raft-forming properties of Rennie alginate suspension. Tytgat, G.N., Simoneau, G. Aliment. Pharmacol. Ther. (2006) [Pubmed]
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