Disease relevance of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• Evaluation of carbenoxolone sodium in the treatment of duodenal ulcer [1].
• Neither basal nor peak acid output changed significantly after treatment for four weeks with carbenoxolone sodium as Biogastrone tablets in patients with gastric ulcer or Duogastrone capsules in patients with duodenal ulcer [2].
• The related triterpenoid compounds carbenoxolone sodium (CBX) and cicloxolone sodium (CCX) have been investigated in clinical trials for treatment of herpes simplex virus (HSV) infections [3].
• The fistula healed with conservative management and treatment with carbenoxolone sodium [4].
• Thus Pyrogastrone is more effective in the treatment of reflux esophagitis than the most efficacious compound in current use [5].

High impact information on (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• Effect of carbenoxolone sodium on human gastric acid secretion [2].
• The concentrations of intraepithelial lymphocytes and polymorphonuclear leucocytes in lesser curve and prepyloric gastirc ulcers were compared, the effect of treatment with carbenoxolone sodium was studied [6].
• The licorice derivative, carbenoxolone sodium, is a potent inhibitor of the enzyme 11 beta-hydroxysteroid dehydrogenase [7].
• The influence of carbenoxolone sodium on HCO-3 transport has been examined in spontaneously alkalinizing amphibian antral (Necturus and Rana catesbeiana) and proximal duodenal (Rana catesbeiana) mucosa and in cimetidine-treated fundic mucosa (Rana temporaria) in vivo [8].
• The fall in potential difference (p.d.) across the gastric mucosa induced by aspirin has been studied before and after administration of carbenoxolone sodium in normal subjects [9].

Chemical compound and disease context of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• The first example is liquorice root, its active principle carbenoxolone, and the drugs Biogastrone and Caved-S for the treatment of gastic, peptic and duodenal ulcers; the second example is the fruits of the milk thistle, its active principles silymarin and silybinin as well as the drug Legalon for the treatment of liver diseases [10].
• Controlled comparison of cimetidine and carbenoxolone sodium in gastric ulcer [11].
• The study with concomitant chlorpropamide treatment was repeated with 6 gastric ulcer patients on an established Biogastrone regimen [12].
• Summary: Among drugs recently introduced into Canada for treatment of gastrointestinal disease are carbenoxolone sodium (used in treating gastric ulcer) and metoclopramide hydrochloride (which modifies upper gastrointestinal tract motility) [13].

Biological context of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• A 76-year-old on long-term Lasix and Pyrogastrone presented with stridor [14].
• In the group treated with Duogastrone the following side effects were noted: weight gain, edema, mild hypokalemia, increase in blood pressure and slight increases in serum concentrations of lactic dehydrogenase and alkaline phosphatase [15].

Anatomical context of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• A quantitative morphological study of the effects of carbenoxolone sodium on duodenal goblet-cells of the rat [16].
• The effects of sodium carbenoxolone on the stability of cellular membranes [17].

Associations of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid with other chemical compounds

• In the present study four volunteers each received a single 100 mg dose of Biogastrone and the plasma half-life of carbenoxolone was determined [12].

Gene context of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• The results suggest that histamine H2-receptor blockade is at least as effective as carbenoxolone sodium for benign gastric ulcer and produces fewer side effects [11].

Analytical, diagnostic and therapeutic context of (2S,6aS,6aS,8aS,10S)-10-(3-carboxypropanoyloxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid

• The responses to both adrenalectomy and carbenoxolone sodium treatment suggest that the observed responses to corticosteroids can occur in the physiological range of endogenous circulating corticosteroids [18].
• It was found that carbenoxolone sodium, anticholinergic drug therapy, bed rest in hospital, and advice to cease smoking did not accelerate ulcer healing [19].
• A study was made of the effect of age, sex, ulcer size, bed rest, carbenoxolone sodium and anticholinergic drug therapy, and advice to cease smoking on the healing rate of chronic gastric ulcer determined radiologically over 21 days in a factorially designed experiment in 54 patients admitted to hospital [19].
• Evaluation of Duogastrome (carbenoxolone sodium) for the treatment of duodenal ulcer: a multicentre study [15].
• A double-blind study was carried out in 152 Canadian patients, 76 given Duogastrone (carbenoxolone sodium) capsules, 50 mg qid, and 76 given placebo capsules qid for 6 weeks [15].

References