Disease relevance of Kill-Ko Rat Killer

• Twelve dogs (2 groups of 6) were given 2.5 mg of diphenadione/kg of body weight for 3 days [1].
• Also, no acute toxicity was noted for snails and slugs that feed on diphacinone baits [2].
• Diphacinone toxicity, von Willebrand's Disease, and Ehrlichia canis in a dog [3].

High impact information on Kill-Ko Rat Killer

• Other examples of transporter homologs with regulatory functions have recently been described in fungi as well [Madi L, et al. Genetics 1997; 146:499-508 (Ref. 3). and Didion T, et al. Mol Microbiol 1998;27:643-650 (Ref. 4)] [4].
• Sensitive fluorescence detection was possible for the coumarin-based rodenticides but not for diphacinone and chlorophacinone [5].
• In addition to unchanged diphacinone, four hydroxylated metabolites were identified in feces and liver [6].
• A method was developed for the determination of seven anticoagulant rodenticides, coumafuryl, pindone, warfarin, diphacinone, chlorophacinone, bromadiolone, and brodifacoum, in diverse matrices, animal feed, cooked beef, and fruit-flavored beverages using high-performance liquid chromatography/electrospray/mass spectrometry [7].
• Effect of diphacinone on blood coagulation in Spermophilus beecheyi as a basis for determining optimal timing of field bait applications [8].

Chemical compound and disease context of Kill-Ko Rat Killer

• Five cases of brodifacoum poisoning, 2 of bromadiolone, and 3 of diphacinone toxicity were verified [9].
• Vitamin K1 (5 mg/kg of body weight/day divided for several 5-day regimens) was effective in preventing bleeding diathesis in diphacinone-poisoned dogs [10].

Biological context of Kill-Ko Rat Killer

• As time following diphacinone dosing increased, there was higher individual variation in blood-clotting time [8].

Analytical, diagnostic and therapeutic context of Kill-Ko Rat Killer

• Bleeding was observed in the diphacinone-treated dogs up to 2 weeks after treatment [10].
• Production of antibodies and development of an immunoassay for the anticoagulant, diphacinone [11].
• Diphacinone was detected in a serum sample drawn 60 d post-exposure using gradient and isocratic HPLC methods with fluorescence and UV detection [12].

References