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Chemical Compound Review

Brodifakum     3-[3-[4-(4- bromophenyl)phenyl]- 1,2,3,4...

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Disease relevance of Klerat

  • The vitamin K metabolism of three patients with factitious purpura due to brodifacoum ingestion was studied [1].
  • On admission, the brodifacoum level was 731 micrograms/L and the patient suffered severe urinary tract hemorrhage, requiring transfusion of blood products [2].
  • CONCLUSION: This case demonstrates that brodifacoum poisoning is not an absolute contraindication to organ donation from brain-dead patients who have sustained a fatal ingestion [3].
  • CASE: A woman presented at 22 weeks' gestation in hemorrhagic diathesis, attributed to the ingestion of rat poison containing brodifacoum several days earlier [4].
  • In this case of an intentional ingestion of brodifacoum, a longitudinal analysis of specific coagulation factor derangements was carried out in an attempt to guide a future treatment strategy for this type of toxicity [5].

Psychiatry related information on Klerat


High impact information on Klerat


Chemical compound and disease context of Klerat


Biological context of Klerat


Anatomical context of Klerat


Associations of Klerat with other chemical compounds


Analytical, diagnostic and therapeutic context of Klerat


  1. Surreptitious ingestion of a long-acting vitamin K antagonist/rodenticide, brodifacoum: clinical and metabolic studies of three cases. Weitzel, J.N., Sadowski, J.A., Furie, B.C., Moroose, R., Kim, H., Mount, M.E., Murphy, M.J., Furie, B. Blood (1990) [Pubmed]
  2. Case management and plasma half-life in a case of brodifacoum poisoning. Hollinger, B.R., Pastoor, T.P. Arch. Intern. Med. (1993) [Pubmed]
  3. Successful donation and transplantation of multiple organs after fatal poisoning with brodifacoum, a long-acting anticoagulant rodenticide: case report. Ornstein, D.L., Lord, K.E., Yanofsky, N.N., Cornell, C.J., Zacharski, L.R. Transplantation (1999) [Pubmed]
  4. Pregnancy outcome after maternal poisoning with brodifacoum, a long-acting warfarin-like rodenticide. Zurawski, J.M., Kelly, E.A. Obstetrics and gynecology. (1997) [Pubmed]
  5. Evaluation of coagulation factor abnormalities in long-acting anticoagulant overdose. Hoffman, R.S., Smilkstein, M.J., Goldfrank, L.R. J. Toxicol. Clin. Toxicol. (1988) [Pubmed]
  6. Brodifacoum intoxication with marijuana smoking. La Rosa, F.G., Clarke, S.H., Lefkowitz, J.B. Arch. Pathol. Lab. Med. (1997) [Pubmed]
  7. Rodenticide-induced coagulopathy in a young child. A case of Munchausen syndrome by proxy. Babcock, J., Hartman, K., Pedersen, A., Murphy, M., Alving, B. The American journal of pediatric hematology/oncology. (1993) [Pubmed]
  8. Spontaneous hemorrhage associated with accidental brodifacoum poisoning in a child. Travis, S.F., Warfield, W., Greenbaum, B.H., Molokisher, M., Siegel, J.E. J. Pediatr. (1993) [Pubmed]
  9. The long-term effects of the rodenticide, brodifacoum, on blood coagulation and vitamin K metabolism in rats. Mosterd, J.J., Thijssen, H.H. Br. J. Pharmacol. (1991) [Pubmed]
  10. Accidental poisoning with a superwarfarin compound (brodifacoum) in a child. Watts, R.G., Castleberry, R.P., Sadowski, J.A. Pediatrics (1990) [Pubmed]
  11. Dispositional and pharmacodynamic characteristics of brodifacoum in warfarin-sensitive rats. Bachmann, K.A., Sullivan, T.J. Pharmacology (1983) [Pubmed]
  12. Inhibition of thrombin-induced endothelium-dependent relaxation after coronary ischemia in the dog: possible role of the coagulation cascade. Winn, M.J., Ku, D.D., Nelson, J.M. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
  13. Comparative effect of the three rodenticides warfarin, difenacoum and brodifacoum on eight rodent species in short feeding periods. Lund, M. The Journal of hygiene. (1981) [Pubmed]
  14. Trials of the anticoagulant rodenticide WBA 8119 against confined colonies of warfarin-resistant house mice (Mus musculus L.). Roew, F.P., Bradfield, A. The Journal of hygiene. (1976) [Pubmed]
  15. A study of the relationship between the pharmacokinetics and the pharmacodynamics of the 4-hydroxycoumarin anticoagulants warfarin, difenacoum and brodifacoum in the rabbit. Breckenridge, A.M., Cholerton, S., Hart, J.A., Park, B.K., Scott, A.K. Br. J. Pharmacol. (1985) [Pubmed]
  16. Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Bruno, G.R., Howland, M.A., McMeeking, A., Hoffman, R.S. Annals of emergency medicine. (2000) [Pubmed]
  17. Assessment of risks of brodifacoum to non-target birds and mammals in New Zealand. Eason, C.T., Murphy, E.C., Wright, G.R., Spurr, E.B. Ecotoxicology (2002) [Pubmed]
  18. Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation. Trivedi, L.S., Rhee, M., Galivan, J.H., Fasco, M.J. Arch. Biochem. Biophys. (1988) [Pubmed]
  19. The determination of the anticoagulant rodenticide brodifacoum in blood serum by liquid chromatography with fluorescence detection. Felice, L.J., Murphy, M.J. Journal of analytical toxicology. (1989) [Pubmed]
  20. Brodifacoum toxicosis in two neonatal puppies. Munday, J.S., Thompson, L.J. Vet. Pathol. (2003) [Pubmed]
  21. A comparative study of the effects of warfarin and brodifacoum on the relationship between vitamin K1 metabolism and clotting factor activity in warfarin-susceptible and warfarin-resistant rats. Leck, J.B., Park, B.K. Biochem. Pharmacol. (1981) [Pubmed]
  22. A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits. Hart, J.A., Haynes, B.P., Park, B.K. Biochem. Pharmacol. (1984) [Pubmed]
  23. The multi-residue determination of coumarin-based anticoagulant rodenticides in animal materials by high-performance liquid chromatography. Mundy, D.E., Machin, A.F. J. Chromatogr. (1982) [Pubmed]
  24. 'Superwarfarin' poisoning leading to prolonged coagulopathy. Hui, C.H., Lie, A., Lam, C.K., Bourke, C. Forensic Sci. Int. (1996) [Pubmed]
  25. Determination of brodifacoum and bromadiolone residues in rodent and canine liver. Ray, A.C., Murphy, M.J., DuVall, M.D., Reagor, J.C. Am. J. Vet. Res. (1989) [Pubmed]
  26. Rapid determination of three anticoagulant rodenticides in whole blood by liquid chromatography coupled with electrospray ionization mass spectrometry. Jin, M.C., Chen, X.H. Rapid Commun. Mass Spectrom. (2006) [Pubmed]
  27. Quantification of brodifacoum in plasma and liver tissue by HPLC. O'Bryan, S.M., Constable, D.J. Journal of analytical toxicology. (1991) [Pubmed]
  28. Successful liver transplantation from a donor with brodifacoum intoxication. Emre, S., Kitabayashi, K., Miller, C.M. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. (1999) [Pubmed]
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