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Chemical Compound Review

Bromoquinol     2-bromobenzene-1,4-diol

Synonyms: SureCN48156, NSC-3977, AG-G-06468, ACMC-209m42, ANW-32928, ...
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Disease relevance of NSC 3977

  • There is a specific sequence of events in 2-bromohydroquinone-induced toxicity [1].
  • The basis of extracellular acidosis amelioration of 2-bromohydroquinone (BHQ)-induced renal proximal tubular cell death was determined by comparing the metabolism, uptake and mitochondrial effects of BHQ (0.2 mM) and bromoquinone (BQ) (0.05 mM) on isolated rabbit renal proximal tubules incubated in pH 7.4 and pH 6.4 buffers [2].

High impact information on NSC 3977


Biological context of NSC 3977


Associations of NSC 3977 with other chemical compounds


  1. Cellular toxicity of bromobenzene and bromobenzene metabolites to rabbit proximal tubules: the role and mechanism of 2-bromohydroquinone. Schnellmann, R.G., Mandel, L.J. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  2. Mechanism of pH amelioration of 2-bromohydroquinone-induced toxicity to rabbit renal proximal tubules. Rodeheaver, D.P., Schnellmann, R.G. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  3. Identification of 2-bromohydroquinone as a metabolite of bromobenzene and o-bromophenol: implications for bromobenzene-induced nephrotoxicity. Lau, S.S., Monks, T.J., Gillette, J.R. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  4. Glutathione conjugates of 2-bromohydroquinone are nephrotoxic. Monks, T.J., Lau, S.S., Highet, R.J., Gillette, J.R. Drug Metab. Dispos. (1985) [Pubmed]
  5. 2-Bromohydroquinone-induced toxicity to rabbit renal proximal tubules: evidence against oxidative stress. Schnellmann, R.G. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  6. Proteinases in renal cell death. Yang, X., Schnellmann, R.G. Journal of toxicology and environmental health. (1996) [Pubmed]
  7. Proteases in renal cell death: calpains mediate cell death produced by diverse toxicants. Schnellmann, R.G., Williams, S.W. Renal failure. (1998) [Pubmed]
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