Chemical Compound Review:
acivicin (2S)-2-amino-2-[(5S)-3- chloro-4,5-dihydro...
Synonyms:
Acivicine, Acivicino, Acivicinum, ACIA, SureCN4159, ...
- Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin. Nichols, K.E., Chitneni, S.R., Moore, J.O., Weinberg, J.B. Blood (1989)
- Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture. Williams, M.G., Earhart, R.H., Bailey, H., McGovren, J.P. Cancer Res. (1990)
- Effects of acivicin and dipyridamole on hepatoma 3924A cells. Zhen, Y.S., Lui, M.S., Weber, G. Cancer Res. (1983)
- Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin). Jayaram, H.N., Ardalan, B., Deas, M., Johnson, R.K. Cancer Res. (1985)
- Different sites of acivicin binding and inactivation of gamma-glutamyl transpeptidases. Smith, T.K., Ikeda, Y., Fujii, J., Taniguchi, N., Meister, A. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Inhibition of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) messenger RNA (mRNA) expression in HL-60 leukemia cells by pentoxifylline and dexamethasone: dissociation of acivicin-induced TNF-alpha and IL-1 beta mRNA expression from acivicin-induced monocytoid differentiation. Weinberg, J.B., Mason, S.N., Wortham, T.S. Blood (1992)
- Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole. Fischer, P.H., Pamukcu, R., Bittner, G., Willson, J.K. Cancer Res. (1984)
- Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity. Hanigan, M.H., Gallagher, B.C., Taylor, P.T., Large, M.K. Cancer Res. (1994)
- Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin). Ardalan, B., Jayaram, H.N., Johnson, R.K. Cancer Res. (1983)
- Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glutathion-S-yl)hydroquinone. Peters, M.M., Jones, T.W., Monks, T.J., Lau, S.S. Carcinogenesis (1997)
- Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma. Elson, P.J., Kvols, L.K., Vogl, S.E., Glover, D.J., Hahn, R.G., Trump, D.L., Carbone, P.P., Earle, J.D., Davis, T.E. Investigational new drugs. (1988)
- Efficiency of homocysteine plus copper in inducing apoptosis is inversely proportional to gamma-glutamyl transpeptidase activity. Bessede, G., Miguet, C., Gambert, P., Neel, D., Lizard, G. FASEB J. (2001)
- Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials. McGovren, J.P., Pratt, E.A., Belt, R.J., Taylor, S.A., Benjamin, R.S., Ardalan, B., Ohnuma, T. Cancer Res. (1985)
- Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501). Meck, R.A., Clubb, K.J., Allen, L.M., Yunis, A.A. Cancer Res. (1981)
- Relationship of acivicin-induced monocytoid differentiation of human myeloid leukemia cells to acivicin-induced modulation of growth factor, cytokine, and protooncogene mRNA expression. Weinberg, J.B., Mason, S.N. Cancer Res. (1991)
- Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase. Rosenfeld, H., Roberts, J. Cancer Res. (1981)
- Phase I clinical trial of a combination of dipyridamole and acivicin based upon inhibition of nucleoside salvage. Willson, J.K., Fischer, P.H., Tutsch, K., Alberti, D., Simon, K., Hamilton, R.D., Bruggink, J., Koeller, J.M., Tormey, D.C., Earhart, R.H. Cancer Res. (1988)
- The phagocytosis-associated respiratory burst in human monocytes is associated with increased uptake of glutathione. Seres, T., Knickelbein, R.G., Warshaw, J.B., Johnston, R.B. J. Immunol. (2000)
- Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N., Lieberman, M.W. J. Biol. Chem. (1997)
- The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. Nakamura, J., Straub, K., Wu, J., Lou, L. J. Biol. Chem. (1995)
- On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis. Raschle, T., Amrhein, N., Fitzpatrick, T.B. J. Biol. Chem. (2005)
- Biochemical assessment of the effects of acivicin and dipyridamole given as a continuous 72-hour intravenous infusion. Fischer, P.H., Willson, J.K., Risueno, C., Tutsch, K., Bruggink, J., Ranhosky, A., Trump, D.L. Cancer Res. (1988)
- Luminal and basolateral membrane transport of glutathione in isolated perfused S(1), S(2), and S(3) segments of the rabbit proximal tubule. Parks, L.D., Zalups, R.K., Barfuss, D.W. J. Am. Soc. Nephrol. (2000)
- Direct evidence of intercellular sharing of glutathione via metabolic cooperation. Kavanagh, T.J., Martin, G.M., Livesey, J.C., Rabinovitch, P.S. J. Cell. Physiol. (1988)