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Chemical Compound Review

Priaxim     (2S)-2-[2-(4- fluorophenyl)benzooxazol-5...

Synonyms: Flunoxaprofen, Flunoxaprofeno, flunoxaprofene, SureCN25196, MK-830, ...
 
 
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Disease relevance of Priaxim

 

High impact information on Priaxim

 

Biological context of Priaxim

 

Anatomical context of Priaxim

  • The anti-inflammatory activity and the eicosanoid generation in rat gastric mucosa after a single oral dose of S-(+)-2(4-fluorophenyl)-alpha-methyl-5-benzoxazolacetic acid (flunoxaprofen, 10 mg/kg) or indomethacin (5 mg/kg) were compared [7].
 

Associations of Priaxim with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Priaxim

  • Determination of flunoxaprofen enantiomers in biological fluids by high-performance liquid chromatography [8].
  • A clinical study on normal volunteers was performed in order to establish the pharmacokinetic pattern of the non-steroidal antiinflammatory drug S-(+)-2-(4-fluorophenyl-a-methyl-5-benzoxazole-acetic acid (flunoxaprofen, Priaxim, FLU) after oral administration or after transcutaneous absorption [9].
  • Blood was withdrawn at different time intervals up to 120 h in rats and up to 48 h in man and serum levels of flunoxaprofen enantiomers were determined by a HPLC method [10].

References

  1. Influence of rat prenatal and postnatal exposure to a non-steroidal anti-inflammatory agent (flunoxaprofen) on cardiovascular function in the progeny. Filippelli, A., Marrazzo, R., Susanna, V., Cenicola, M.L., Servodio, R., Romano, A.R., Molinario, L., Russo, S., Marmo, E. Prostaglandins Leukot. Essent. Fatty Acids (1989) [Pubmed]
  2. Multicentre clinical study with flunoxaprofen in osteoarthritis: preliminary data on 154 patients. Forgione, A., Zanoboni, A., Zanoboni-Muciaccia, W., Sacchi, C., Pupita, F. International journal of clinical pharmacology research. (1985) [Pubmed]
  3. Determination of the quaternary compound ciclotropium in human biological material after hydrolysis and derivatization with the fluorophor flunoxaprofen chloride. Liebmann, B., Henke, D., Spahn-Langguth, H., Mutschler, E. J. Chromatogr. (1991) [Pubmed]
  4. Pharmacokinetics of flunoxaprofen in rats, dogs, and monkeys. Segre, G., Bianchi, E., Zanolo, G. Journal of pharmaceutical sciences. (1988) [Pubmed]
  5. Comparison of the pro-oxidative interactions of flunoxaprofen and benoxaprofen with human polymorphonuclear leucocytes in vitro. Van Rensburg, A.J., Theron, A.J., Anderson, R. Agents Actions (1991) [Pubmed]
  6. Interference of the new antiinflammatory compound flunoxaprofen with eicosanoid formation in various biological systems. Berti, F., Galli, G., Omini, C., Rossoni, G., Brunelli, G., Daffonchio, L., Viganò, T., Magni, F., Crivellari, M.T., Forgione, A. Arzneimittel-Forschung. (1987) [Pubmed]
  7. Flunoxaprofen, a new non-steroidal anti-inflammatory drug, does not interfere with prostaglandin synthesis in rat gastric mucosa. Sacchi, C., Magni, F., Toia, A., Cazzaniga, F., Galli, G., Berti, F. Pharmacol. Res. (1989) [Pubmed]
  8. Determination of flunoxaprofen enantiomers in biological fluids by high-performance liquid chromatography. Pedrazzini, S., Zanoboni-Muciaccia, W., Sacchi, C., Forgione, A. J. Chromatogr. (1987) [Pubmed]
  9. Pharmacokinetic study in man with the non-steroidal antiinflammatory drug flunoxaprofen. Serum concentration-time profile after oral or topical preparations. Bareggi, S.R., Pedrazzini, S., De Angelis, M. Arzneimittel-Forschung. (1988) [Pubmed]
  10. Stereochemical pharmacokinetics of the 2-arylpropionic acid non-steroidal antiinflammatory drug flunoxaprofen in rats and in man. Pedrazzini, S., De Angelis, M., Muciaccia, W.Z., Sacchi, C., Forgione, A. Arzneimittel-Forschung. (1988) [Pubmed]
 
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