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Chemical Compound Review

Fenoverina     2-[4-(benzo[1,3]dioxol-5...

Synonyms: Fenoverine, Spasmopriv, Fenoverinum, SureCN25003, AG-K-40634, ...
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Disease relevance of Fenoverine


High impact information on Fenoverine


Biological context of Fenoverine


Anatomical context of Fenoverine

  • Based on the reported data, it is concluded that fenoverine does not act as a muscarinic or opiate-receptor antagonist, but that its main mechanism of action is due to modulation of the calcium gradient across the muscular cell membrane by regulating the influx of the extracellular calcium and/or the release of the intracellular pool [6].
  • We describe a high-performance liquid chromatographic method for the determination of fenoverine in striated muscle, smooth muscle, myocardium, and liver tissue [7].

Analytical, diagnostic and therapeutic context of Fenoverine


  1. Fenoverine-induced rhabdomyolysis. Chariot, P., Ratiney, R., Le Maguet, F., Fourestié, V., Astier, A., Gherardi, R. Human & experimental toxicology. (1995) [Pubmed]
  2. Research into individual predisposition to develop acute rhabdomyolysis attributed to fenoverine. Jouglard, J., Kozak-Ribbens, G., de Haro, L., Cozzone, P.J. Human & experimental toxicology. (1996) [Pubmed]
  3. Rhabdomyolysis induced by fenoverine: a case report and literature review. Chen, C.W., Chang, M.H. Acta neurologica Taiwanica. (2005) [Pubmed]
  4. Fenoverine inhibition of calcium channel currents in single smooth muscle cells from rat portal vein and myometrium. Mironneau, J., Arnaudeau, S., Mironneau, C. Br. J. Pharmacol. (1991) [Pubmed]
  5. Determination of fenoverine, a modulator of smooth muscle motility, in capsules and in human plasma: application to dosage form stability and a pilot study in humans. Hu, O.Y., Chen, P.H., Fang, Y.J., Tang, H.S., Pao, L.H., Kwok, K.M., King, M.L. Journal of pharmaceutical sciences. (1992) [Pubmed]
  6. Fenoverine: a novel synchronizer of smooth muscle motility by interference with cellular calcium flow. Gonella, J., Lalanne, C., Mironneau, J. Current medical research and opinion. (1987) [Pubmed]
  7. Determination of fenoverine in tissue samples by high-performance liquid chromatography. Ratiney, R., Astier, A., Chariot, P. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
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