Disease relevance of Fenoverine

• Fenoverine-induced rhabdomyolysis [1].
• The probability of finding by chance such rare muscle disorders associated with the equally rare rhabdomyolysis attributed to fenoverine is practically zero [2].
• Physicians should be aware of the possibility of rhabdomyolysis in patients receiving fenoverine, whether they are healthy or have musculoskeletal or liver dysfunction [3].
• The foregoing symptoms and signs and abnormal biochemistry improved gradually after discontinuation of fenoverine use [3].
• A 77-year-old patient without previous history of liver diseases received fenoverine therapy for four days due to abdominal pain [3].

High impact information on Fenoverine

• In myometrium, the fenoverine concentration which blocked 50% of the slow Ca2+ channel current (holding potential of -70 mV) was 2.3 microM [4].
• 1. The effects of fenoverine, an antispasmodic drug, have been studied on the Ca2+ channel currents of isolated cells from rat portal vein and pregnant myometrium by the patch-clamp technique (whole-cell configuration) [4].
• 4. When cells held at depolarized membrane potentials at which fast or slow Ca2+ channel currents were strongly inactivated, the inhibitory effects of fenoverine were enhanced on both Ca2+ channel currents which indicates that the fenoverine-induced inhibition was voltage-dependent [4].
• Determination of fenoverine, a modulator of smooth muscle motility, in capsules and in human plasma: application to dosage form stability and a pilot study in humans [5].
• Fenoverine is a novel, potent, musculotropic, spasmolytic agent that affects primarily the gastrointestinal tract, bile duct, and female genital organs [5].

Biological context of Fenoverine

• Based on the hypothesis that such a phenomenon may occur in rare cases of rhabdomyolysis attributed to fenoverine (DCI), we designed a protocol to look for a genetic predisposition [2].

Anatomical context of Fenoverine

• Based on the reported data, it is concluded that fenoverine does not act as a muscarinic or opiate-receptor antagonist, but that its main mechanism of action is due to modulation of the calcium gradient across the muscular cell membrane by regulating the influx of the extracellular calcium and/or the release of the intracellular pool [6].
• We describe a high-performance liquid chromatographic method for the determination of fenoverine in striated muscle, smooth muscle, myocardium, and liver tissue [7].

Analytical, diagnostic and therapeutic context of Fenoverine

• A simple, specific, and accurate HPLC method was developed for the determination of fenoverine in capsules and plasma [5].
• This method has been successfully applied to stability studies of fenoverine capsules and to a pilot study in a normal, healthy volunteer following oral administration of fenoverine [5].
• This method is well suited for the determination of fenoverine in various organs in animal experiments [7].
• Determination of fenoverine in tissue samples by high-performance liquid chromatography [7].

References