Disease relevance of Genitalia, Female

• McKusick-Kaufman syndrome (MKS) is an autosomal recessive disorder characterized by post-axial polydactyly, congenital heart defects and hydrometrocolpos, a congenital structural abnormality of female genitalia [1].
• A further investigation on the aging process of female genital organs in control mice revealed that their senility seemed to be preceded by the formation of ovarian cysts which first appeared at 6 months of age with a concomitant elevation of plasma 17 beta-estradiol level [2].

Psychiatry related information on Genitalia, Female

• Studies of 29 children revealed that despite the absence of the typical postnatal and pubertal androgen surges and the presence of female genitalia, all female-assigned subjects displayed a marked male-typical shift in psychosocial and psychosexual development [3].

High impact information on Genitalia, Female

• Using dachshund as a gene target for Decapentaplegic and Wingless signals, it was also found that Doublesex(M) and Doublesex(F) both positively and negatively control the response to these signals in male and female genitalia, respectively [4].
• Fluconazole can rapidly penetrate from plasma into the female genital organs, supporting high efficacy of fluconazole against fungal infections in the field of gynecology [5].
• Among 22 patients with a duplication in Xp, nine had unambiguous female genitalia and a well-documented duplication of the DSS region [6].
• Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs [7].
• Keratin is a strong, fibrous protein that coats the skin, male genitalia and some tissues in the mouth and female genitalia [8].

Biological context of Genitalia, Female

• Complete masculinisation of the external genitalia (type V of Prader classification) is reported in two siblings with normal internal female genitalia, normal ovaries and a 46,XX chromosome constitution in different cell lines without any detectable source of exposure to androgen during pregnancy [9].

Anatomical context of Genitalia, Female

• The present results suggest that the porcine female genital organs receive innervation by somatostatin- and neuropeptide Y-containing nerve fibers, but their exact functional role remains to be established [10].
• Fenoverine is a novel, potent, musculotropic, spasmolytic agent that affects primarily the gastrointestinal tract, bile duct, and female genital organs [11].
• In this article we discuss the reconstruction of the female genitalia in those that have had significant androgen stimulation as well as those with near normal external genitalia but significant urogenital sinus anomalies [12].
• Accessory male genital organs including the prostate, seminal vesicle, and coagulating gland also demonstrated a positive reaction, but the testis and female genital organs including uterus and ovaries did not [13].
• The female genitalia, the urinary tract, the respiratory system, the pancreas, the heart and the skin of several mammalian species, including rat, mouse, guinea pig, cat, pig, monkey and man were fixed in para-benzoquinone and portions of each organ were snap frozen [14].

Associations of Genitalia, Female with chemical compounds

• The distribution and co-localization of immunoreactivity to nitric oxide synthase, vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs [15].
• This androgen insensitivity results in development of normal external female genitalia, with high testosterone concentrations being released from developing testicles [16].
• Vasoactive intestinal polypeptide, substance P, neuropeptide Y and peptide histidine isoleucine immunoreactivities have been demonstrated in the female genitalia of rat, cat, mouse and guinea-pig using immunocytochemistry and radioimmunoassay [17].
• AIM: To determine the ultrastructural effects of sildenafil on the female genital organs [18].
• In that case, prenatal treatment with dexamethasone resulted in normal female genitalia [19].

Gene context of Genitalia, Female

• The analysis of the GPR54 mutant mice revealed developmental abnormalities of both male and female genitalia and histopathological changes in tissues which normally contain sexually dimorphic features [20].
• Expression of RCAS1 in female genital organs [21].
• Consistent with the fact that this infant had normal female genitalia, the SRY gene was not detected in the Y chromosome portion of the der(Y) [22].
• Two less frequent causes of CAH 17alpha-Hydroxylase/17,20-lyase and cholesterol desmolase result in external female genitalia in both sexes [23].
• Two patients with XY karyotypes had female genitalia and unmeasurable steroids after stimulation with ACTH and hCG [24].

Analytical, diagnostic and therapeutic context of Genitalia, Female

• VIP, a recently recognized neuropeptide, has been demonstrated by immunohistochemistry in nerves of the human female genital organs [25].
• Physical examination. Part 15. Female genitalia [26].

References