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Chemical Compound Review

beta-Fddc     4-amino-5-fluoro-1-[(2S,5R)- 5...

Synonyms: L-FddC, CHEMBL40724, SureCN913431, AG-K-91463, CTK4C5243, ...
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Disease relevance of beta-Fddc


High impact information on beta-Fddc


Biological context of beta-Fddc


  1. 2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo. Zoulim, F., Dannaoui, E., Borel, C., Hantz, O., Lin, T.S., Liu, S.H., Trépo, C., Cheng, Y.C. Antimicrob. Agents Chemother. (1996) [Pubmed]
  2. Antiviral activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-FddC) and 2',3'-dideoxy-beta-L-cytidine (beta-L-ddC) against hepatitis B virus and human immunodeficiency virus type 1 in vitro. Lin, T.S., Luo, M.Z., Liu, M.C., Pai, S.B., Dutschman, G.E., Cheng, Y.C. Biochem. Pharmacol. (1994) [Pubmed]
  3. L- and D-enantiomers of 2',3'-dideoxycytidine 5'-triphosphate analogs as substrates for human DNA polymerases. Implications for the mechanism of toxicity. Kukhanova, M., Liu, S.H., Mozzherin, D., Lin, T.S., Chu, C.K., Cheng, Y.C. J. Biol. Chem. (1995) [Pubmed]
  4. Removal of anti-human immunodeficiency virus 2',3'-dideoxynucleoside monophosphates from DNA by a novel human cytosolic 3'-->5' exonuclease. Skalski, V., Liu, S.H., Cheng, Y.C. Biochem. Pharmacol. (1995) [Pubmed]
  5. Early detection of mixed mutations selected by antiretroviral agents in HIV-infected primary human lymphocytes. Schinazi, R.F., Schlueter-Wirtz, S., Stuyver, L. Antivir. Chem. Chemother. (2001) [Pubmed]
  6. Immunomodulatory and antiviral activities of 2',3'-dideoxy-beta-L-cytidine and 2',3'-dideoxy-beta-L-5-fluorocytidine. Gagnon, L., Nordstrom, P.A., Duchaine, J., Jutras, D., Hamel, M., Barbeau, D., Hooker, E., Ashman, C., Cammack, N., Tse, A. Immunopharmacology and immunotoxicology. (1995) [Pubmed]
  7. In vitro and in vivo metabolism and pharmacokinetics of bis [(t-butyl)-S-acyl-2-thioethyl]-beta-L-2',3'-dideoxy-5-fluorocytidine monophosphate. Martin, L.T., Cretton-Scott, E., Placidi, L., Faraj, A., Loi, A.G., Schinazi, R.F., McClure, H.M., Gosselin, G., Imbach, J.L., Sommadossi, J.P. Nucleosides Nucleotides Nucleic Acids (2000) [Pubmed]
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