The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-00OFOK     4-amino-1-[5- (hydroxymethyl)oxolan-2...

Synonyms: AG-K-92482, ACMC-209ow4, D0914_SIGMA, SureCN12149465, CHEBI:121037, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC606170


High impact information on NSC606170


Chemical compound and disease context of NSC606170


Biological context of NSC606170


Anatomical context of NSC606170


Associations of NSC606170 with other chemical compounds


Gene context of NSC606170


Analytical, diagnostic and therapeutic context of NSC606170


  1. Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase. St Clair, M.H., Martin, J.L., Tudor-Williams, G., Bach, M.C., Vavro, C.L., King, D.M., Kellam, P., Kemp, S.D., Larder, B.A. Science (1991) [Pubmed]
  2. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides. Perno, C.F., Yarchoan, R., Cooney, D.A., Hartman, N.R., Gartner, S., Popovic, M., Hao, Z., Gerrard, T.L., Wilson, Y.A., Johns, D.G. J. Exp. Med. (1988) [Pubmed]
  3. Phase I studies of 2',3'-dideoxycytidine in severe human immunodeficiency virus infection as a single agent and alternating with zidovudine (AZT). Yarchoan, R., Perno, C.F., Thomas, R.V., Klecker, R.W., Allain, J.P., Wills, R.J., McAtee, N., Fischl, M.A., Dubinsky, R., McNeely, M.C. Lancet (1988) [Pubmed]
  4. Inhibition of duck hepatitis B virus replication by 2',3'-dideoxycytidine. A potent inhibitor of reverse transcriptase. Kassianides, C., Hoofnagle, J.H., Miller, R.H., Doo, E., Ford, H., Broder, S., Mitsuya, H. Gastroenterology (1989) [Pubmed]
  5. Alternating and intermittent regimens of zidovudine and dideoxycytidine in patients with AIDS or AIDS-related complex. Skowron, G., Bozzette, S.A., Lim, L., Pettinelli, C.B., Schaumburg, H.H., Arezzo, J., Fischl, M.A., Powderly, W.G., Gocke, D.J., Richman, D.D., Pottage, J.C., Antoniskis, D., McKinley, G.F., Hyslop, N.E., Ray, G., Simon, G., Reed, N., LoFaro, M.L., Uttamchandani, R.B., Gelb, L.D., Sperber, S.J., Murphy, R.L., Leedom, J.M., Grieco, M.H., Zachary, J., Hirsch, M.S., Spector, S.A., Bigley, J., Soo, W., Merigan, T.C. Ann. Intern. Med. (1993) [Pubmed]
  6. 2'3'-Dideoxycytidine-induced thymic lymphoma correlates with species-specific suppression of a subpopulation of primitive hematopoietic progenitor cells in mouse but not rat or human bone marrow. Irons, R.D., Le, A.T., Som, D.B., Stillman, W.S. J. Clin. Invest. (1995) [Pubmed]
  7. Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs. Gu, Z., Arts, E.J., Parniak, M.A., Wainberg, M.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Shirasaka, T., Yarchoan, R., O'Brien, M.C., Husson, R.N., Anderson, B.D., Kojima, E., Shimada, T., Broder, S., Mitsuya, H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Targeting antiretroviral nucleoside analogues in phosphorylated form to macrophages: in vitro and in vivo studies. Magnani, M., Rossi, L., Brandi, G., Schiavano, G.F., Montroni, M., Piedimonte, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. Allelotype analysis of 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. Zhuang, S.M., Eklund, L.K., Cochran, C., Rao, G.N., Wiseman, R.W., Söderkvist, P. Cancer Res. (1996) [Pubmed]
  11. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine. Gu, Z., Gao, Q., Li, X., Parniak, M.A., Wainberg, M.A. J. Virol. (1992) [Pubmed]
  12. Anti-human immunodeficiency virus type 1 therapy and peripheral neuropathy: prevention of 2',3'-dideoxycytidine toxicity in PC12 cells, a neuronal model, by uridine and pyruvate. Keilbaugh, S.A., Hobbs, G.A., Simpson, M.V. Mol. Pharmacol. (1993) [Pubmed]
  13. Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase. Zhang, D., Caliendo, A.M., Eron, J.J., DeVore, K.M., Kaplan, J.C., Hirsch, M.S., D'Aquila, R.T. Antimicrob. Agents Chemother. (1994) [Pubmed]
  14. Induction of the SOS response in Escherichia coli by azidothymidine and dideoxynucleosides. Mamber, S.W., Brookshire, K.W., Forenza, S. Antimicrob. Agents Chemother. (1990) [Pubmed]
  15. Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues. Doong, S.L., Tsai, C.H., Schinazi, R.F., Liotta, D.C., Cheng, Y.C. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  16. Long-term inhibition of human T-lymphotropic virus type III/lymphadenopathy-associated virus (human immunodeficiency virus) DNA synthesis and RNA expression in T cells protected by 2',3'-dideoxynucleosides in vitro. Mitsuya, H., Jarrett, R.F., Matsukura, M., Di Marzo Veronese, F., DeVico, A.L., Sarngadharan, M.G., Johns, D.G., Reitz, M.S., Broder, S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  17. Multiple initiation sites of DNA replication flanking the origin region of lambda dv genome. Tsurimoto, T., Matsubara, K. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  18. Selective inhibition of the reverse transcription of duck hepatitis B virus by binding of 2',3'-dideoxyguanosine 5'-triphosphate to the viral polymerase. Howe, A.Y., Robins, M.J., Wilson, J.S., Tyrrell, D.L. Hepatology (1996) [Pubmed]
  19. Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene. Owens, J.K., Shewach, D.S., Ullman, B., Mitchell, B.S. Cancer Res. (1992) [Pubmed]
  20. Cellular metabolism of 2',3'-dideoxycytidine, a compound active against human immunodeficiency virus in vitro. Starnes, M.C., Cheng, Y.C. J. Biol. Chem. (1987) [Pubmed]
  21. Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. Hunsucker, S.A., Spychala, J., Mitchell, B.S. J. Biol. Chem. (2001) [Pubmed]
  22. Transport of the antiviral nucleoside analogs 3'-azido-3'-deoxythymidine and 2',3'-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. Yao, S.Y., Cass, C.E., Young, J.D. Mol. Pharmacol. (1996) [Pubmed]
  23. 2',3'-Dideoxycytidine alters calcium buffering in cultured dorsal root ganglion neurons. Werth, J.L., Zhou, B., Nutter, L.M., Thayer, S.A. Mol. Pharmacol. (1994) [Pubmed]
  24. The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics. Smith, K.M., Slugoski, M.D., Loewen, S.K., Ng, A.M., Yao, S.Y., Chen, X.Z., Karpinski, E., Cass, C.E., Baldwin, S.A., Young, J.D. J. Biol. Chem. (2005) [Pubmed]
  25. Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides. Medina, D.J., Tsai, C.H., Hsiung, G.D., Cheng, Y.C. Antimicrob. Agents Chemother. (1994) [Pubmed]
  26. Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2',3'-dideoxycytidine) and BEA005 (2', 3'-dideoxy-3'-hydroxymethylcytidine) in rats, studied by microdialysis. Borg, N., Ståhle, L. Antimicrob. Agents Chemother. (1998) [Pubmed]
  27. Deoxycytidine and 2',3'-dideoxycytidine metabolism in human monocyte-derived macrophages. A study of both anabolic and catabolic pathways. Arnér, E.S., Eriksson, S. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  28. Effect of hydroxyurea on 2',3'-dideoxycytidine activation. Agarwal, R.P., He, J. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  29. Inactivations of p16INK4a-alpha, p16INK4a-beta and p15INK4b genes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced murine lymphomas. Zhuang, S.M., Schippert, A., Haugen-Strano, A., Wiseman, R.W., Söderkvist, P. Oncogene (1998) [Pubmed]
  30. Mutation analysis of the pRb pathway in 2',3'-dideoxycytidine- and 1, 3-butadiene-induced mouse lymphomas. Zhuang, S.M., Wiseman, R.W., Söderkvist, P. Cancer Lett. (2000) [Pubmed]
  31. Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas. Zhuang, S.M., Cochran, C., Goodrow, T., Wiseman, R.W., Söderkvist, P. Cancer Res. (1997) [Pubmed]
  32. Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine. Chen, C.H., Cheng, Y.C. J. Biol. Chem. (1989) [Pubmed]
  33. 2',3'-dideoxycytidine (ddC) toxic neuropathy: a study of 52 patients. Berger, A.R., Arezzo, J.C., Schaumburg, H.H., Skowron, G., Merigan, T., Bozzette, S., Richman, D., Soo, W. Neurology (1993) [Pubmed]
  34. In vitro and in vivo evidence that the antiviral activity of 2',3'-dideoxycytidine is target cell dependent in a feline retrovirus animal model. Polas, P.J., Swenson, C.L., Sams, R., Cheney, C.M., Hayes, K.A., Tarr, M.J., Kociba, G.J., Mathes, L.E. Antimicrob. Agents Chemother. (1990) [Pubmed]
  35. Human red blood cells as bioreactors for the release of 2',3'-dideoxycytidine, an inhibitor of HIV infectivity. Magnani, M., Bianchi, M., Rossi, L., Stocchi, V. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  36. Isolation of experimental anti-AIDS glycerophospholipids by micro-preparative reversed-phase high-performance liquid chromatography. Amari, J.V., Brown, P.R., Pivarnik, P.E., Sehgal, R.K., Turcotte, J.G. J. Chromatogr. (1992) [Pubmed]
WikiGenes - Universities