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Chemical Compound Review

Panaxadiol     (3S,5R,8R,9R,10S,12R,13S,14R,1 7S)-4,4,8,10...

Synonyms: CHEMBL491655, SureCN4401646, AC1L2JYG, ZINC26893090, NSC 308879, ...
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High impact information on Panaxadiol


Biological context of Panaxadiol


Associations of Panaxadiol with other chemical compounds

  • Capillary supercritical fluid chromatographic (SFC) method has been developed for the determination of panaxadiol and panaxatriol in ginseng and its preparations [5].

Gene context of Panaxadiol

  • On normal myocardial cells, Rb1, Rb2, Rb3 20 inhibited the AP and spontaneous contractility, (suggesting the Ca channel blockade action of panaxadiol saponins) [6].


  1. Panaxadiol selectively inhibits cyclin A-associated Cdk2 activity by elevating p21WAF1/CIP1 protein levels in mammalian cells. Jin, Y.H., Choi, J., Shin, S., Lee, K.Y., Park, J.H., Lee, S.K. Carcinogenesis (2003) [Pubmed]
  2. Cdk2 activity is associated with depolarization of mitochondrial membrane potential during apoptosis. Jin, Y.H., Yim, H., Park, J.H., Lee, S.K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. Modification of radiation response in mice by ginsenosides, active components of Panax ginseng. Kim, S.R., Jo, S.K., Kim, S.H. In Vivo (2003) [Pubmed]
  4. Transcriptional activation of Cu/Zn superoxide dismutase and catalase genes by panaxadiol ginsenosides extracted from Panax ginseng. Chang, M.S., Lee, S.G., Rho, H.M. Phytotherapy research : PTR. (1999) [Pubmed]
  5. Determination of panaxadiol and panaxatriol in ginseng and its preparations by capillary supercritical fluid chromatography (SFC). Li, Y.H., Li, X.L., Hong, L., Liu, J.Y., Zhang, M.Y. Biomed. Chromatogr. (1992) [Pubmed]
  6. Influences of ginsenosides Rb1, Rb2, and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes. Jiang, Y., Zhong, G.G., Chen, L., Ma, X.Y. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1992) [Pubmed]
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