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Chemical Compound Review

FURFURAL     furan-2-carbaldehyde

Synonyms: Furfurol, Quakeral, Fufural, Furfurale, Furfurole, ...
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Disease relevance of FURFURAL


High impact information on FURFURAL

  • The importance of the syn conformation and the hydrogen-bonding capability was confirmed by the reduced antiviral activity of the 2-methylfuran and 2-formylfuran analogues [4].
  • Aflatoxin field-resistant maize genotypes exhibited a larger relative concentration of the antifungal aldehyde, furfural (2-furancarboxaldehyde), when compared to the relative concentrations of the field-susceptible varieties tested [5].
  • Cytotoxicity of copper complexes of 2-furaldehyde oxime derivatives in murine and human tissue cultured cell lines [6].
  • In order to induce the same magnitude of cell growth inhibition as the heat-sterilized PD fluids, the concentrations of 2-furaldehyde, glyoxal, and 5-HMF had to be 50 to 350 times higher than those quantified in the PD fluids [7].
  • The fate of furfural (2-furancarboxaldehyde) was investigated in male and female Fischer 344 (F344) rats given single oral doses of 1, 10 and 60 mg/kg and male and female CD1 mice given 1, 20 and 200 mg/kg [carbonyl-14C]furfural [8].

Chemical compound and disease context of FURFURAL

  • RESULTS AND DISCUSSION: From the CH fragments, 2-furfural in TCF, and from the LIG fragments, styrene in ECF showed the highest probabilities of originating from source structures of toxicity [9].

Biological context of FURFURAL


Associations of FURFURAL with other chemical compounds


Analytical, diagnostic and therapeutic context of FURFURAL


  1. Effect of alcohol compounds found in hemicellulose hydrolysate on the growth and fermentation of ethanologenic Escherichia coli. Zaldivar, J., Martinez, A., Ingram, L.O. Biotechnol. Bioeng. (2000) [Pubmed]
  2. DNA-protein cross-link formation in Burkitt lymphoma cells cultured with benzaldehyde and the sedative paraldehyde. Kuykendall, J.R., Jarvi, E.J., Finley, B.L., Paustenbach, D.J. Drug and chemical toxicology (2007) [Pubmed]
  3. Cytotoxicity of copper and cobalt complexes of furfural semicarbazone and thiosemicarbazone derivatives in murine and human tumor cell lines. Hall, I.H., Lackey, C.B., Kistler, T.D., Durham, R.W., Jouad, E.M., Khan, M., Thanh, X.D., Djebbar-Sid, S., Benali-Baitich, O., Bouet, G.M. Die Pharmazie. (2000) [Pubmed]
  4. An evaluation of the antirhinoviral activity of acetylfuran replacements for 3-methylisoxazoles. Are 2-acetylfurans bioisosteres for 3-methylisoxazoles? Bailey, T.R., Diana, G.D., Mallamo, J.P., Vescio, N., Draper, T.L., Carabateas, P.M., Long, M.A., Giranda, V.L., Dutko, F.J., Pevear, D.C. J. Med. Chem. (1994) [Pubmed]
  5. Identification and effects of maize silk volatiles on cultures of Aspergillus flavus. Zeringue, H.J. J. Agric. Food Chem. (2000) [Pubmed]
  6. Cytotoxicity of copper complexes of 2-furaldehyde oxime derivatives in murine and human tissue cultured cell lines. Hall, I.H., Taylor, K., Miller, M.C., Dothan, X., Khan, M.A., Bouet, F.M. Anticancer Res. (1997) [Pubmed]
  7. Are aldehydes in heat-sterilized peritoneal dialysis fluids toxic in vitro? Wieslander, A.P., Andrén, A.H., Nilsson-Thorell, C., Muscalu, N., Kjellstrand, P.T., Rippe, B. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. (1995) [Pubmed]
  8. Metabolism and excretion of [14C]furfural in the rat and mouse. Parkash, M.K., Caldwell, J. Food Chem. Toxicol. (1994) [Pubmed]
  9. Multivariate statistics of the pyrolysis products of high molecular components in pulping wastewaters to explain their toxicity. Paasivirta, J., Kukkola, J., Knuutinen, J., Pessala, P., Schultz, E., Herve, S. Environmental science and pollution research international. (2005) [Pubmed]
  10. Discoloration of dental pellicle by tannic acid. Nordbo, H. Acta Odontol. Scand. (1977) [Pubmed]
  11. DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells. Costa, M., Zhitkovich, A., Harris, M., Paustenbach, D., Gargas, M. Journal of toxicology and environmental health. (1997) [Pubmed]
  12. Quantification of deformed peaks in capillary gas chromatography (CGC): application to simultaneous analysis of free fatty acids and less polar compounds in aqueous distillery effluent. Morin-Couallier, E., Bleton, J., Lameloise, M.L., Tchapla, A. Anal. Chim. Acta (2007) [Pubmed]
  13. High-performance liquid chromatographic determination of 2-furaldehyde and 5-hydroxymethyl-2-furaldehyde in fruit juices. Lo Coco, F., Novelli, V., Valentini, C., Ceccon, L. Journal of chromatographic science. (1997) [Pubmed]
  14. A reversed-phase HPLC method for measurement of 5-hydroxymethyl furfuraldehyde and furfuraldehyde in processed juices. Roig, M.G., Bello, J.F., Kennedy, J.F., Rivera, Z.S., Lloyd, L.L. Bioseparation (1992) [Pubmed]
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