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Chemical Compound Review

PARALDEHYDE     2,4,6-trimethyl-1,3,5-trioxane

Synonyms: Elaldehyde, Paraldehyd, Paraldeide, Paral, p-Acetaldehyde, ...
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Disease relevance of PARALDEHYDE


Psychiatry related information on PARALDEHYDE


High impact information on PARALDEHYDE


Chemical compound and disease context of PARALDEHYDE


Biological context of PARALDEHYDE

  • The neurosecretory cells (NSCs) of the brain of the mature larvae and 3 months old diapause pupae of Amsacta collaris Hampson (Lepidopera: arctiidae) have been studied under different temperature regimes (0, 7, 18, 37, and 42 degrees C), using paraldehyde fuchsin and performic acid resorcin fuchsin staining techniques [12].

Anatomical context of PARALDEHYDE


Associations of PARALDEHYDE with other chemical compounds


Gene context of PARALDEHYDE

  • Positive staining for PAS and paraldehyde fuchsin, and a marked reaction to lectins PHA-L4, MAM, and RCA 60 suggested the presence of sialo-glycoproteins in the follicular cavities [21].

Analytical, diagnostic and therapeutic context of PARALDEHYDE


  1. Diazepam and paraldehyde for treatment of severe delirium tremens. A controlled trial. Thompson, W.L., Johnson, A.D., Maddrey, W.L. Ann. Intern. Med. (1975) [Pubmed]
  2. Paraldehyde therapy in childhood status epilepticus. Curless, R.G., Holzman, B.H., Ramsay, R.E. Arch. Neurol. (1983) [Pubmed]
  3. Severe lactic acidosis following paraldehyde administration. Linter, C.M., Linter, S.P. The British journal of psychiatry : the journal of mental science. (1986) [Pubmed]
  4. Pharmacokinetics of paraldehyde disposition in the neonate. Giacoia, G.P., Gessner, P.K., Zaleska, M.M., Boutwell, W.C. J. Pediatr. (1984) [Pubmed]
  5. Outcome of status epilepticus in immature rats varies according to the paraldehyde treatment. Kubová, H., Rejchrtová, J., Redkozubova, O., Mares, P. Epilepsia (2005) [Pubmed]
  6. Interactions of paraldehyde with ethanol and chloral hydrate. Gessner, P.K., Shakarjian, M.P. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  7. Metabolism of [14C]paraldehyde in mice in vivo, generation and trapping of acetaldehyde. Zaleska, M.M., Gessner, P.K. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  8. Metabolism of paraldehyde to acetaldehyde in liver microsomes. Evidence for the involvement of cytochrome P-450. Zaleska, M.M., Gessner, P.K. Biochem. Pharmacol. (1983) [Pubmed]
  9. Continuous infantile spasms as a form of status epilepticus. Coulter, D.L. J. Child Neurol. (1986) [Pubmed]
  10. Simplified staining in situ of neurosecretory cells of the supraoesophageal ganglion of the female Culex pipiens molestus (Forskal) (Diptera: Culicidae). Ghaffar, H.A. Folia morphologica. (1989) [Pubmed]
  11. DNA-protein cross-link formation in Burkitt lymphoma cells cultured with benzaldehyde and the sedative paraldehyde. Kuykendall, J.R., Jarvi, E.J., Finley, B.L., Paustenbach, D.J. Drug and chemical toxicology (2007) [Pubmed]
  12. An analytical study of the neurosecretory cells of the brain of the mature larvae and diapause pupae of Amsacta collaris Hampson (Lepidoptera: Arctiidae) under different temperature regimes. Awasthi, V.B., Singh, U.V. Gegenbaurs morphologisches Jahrbuch. (1982) [Pubmed]
  13. The analysis of blood serum for paraldehyde by ultrafiltration and gas chromatography with a wide-bore capillary column. Hessel, D.W. Journal of analytical toxicology. (1988) [Pubmed]
  14. Effects of paraldehyde on the convulsions induced by administration of soman in rats. Carpentier, P., Lallement, G., Bodjarian, N., Tarricone, A., Blanchet, G. Fundamental & clinical pharmacology. (1992) [Pubmed]
  15. The morphological and histochemical neurosecretory magnocellular system in the rat after administration of chlorpromazine. Arciszewska, E., Borowska, H., Sawicki, B. Folia morphologica. (2004) [Pubmed]
  16. Localization of insulin-like immunoreactivity in the synganglion of nymphal and adult Dermacentor variabilis (Acari: Ixodidae). Davis, H.H., Dotson, E.M., Oliver, J.H. Exp. Appl. Acarol. (1994) [Pubmed]
  17. Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. Ahmad, S., Ellis, J.C., Kamwendo, H., Molyneux, E. Lancet (2006) [Pubmed]
  18. EEG in anaesthetized rats. Sim, M.K., Chua, M.E. Pharmacol. Toxicol. (1989) [Pubmed]
  19. Abnormality in body curvature of Cyprinus carpio after injection of anaesthetics. Jain, S.M., Durve, V.S. Acta morphologica Neerlando-Scandinavica. (1978) [Pubmed]
  20. Mania pre-lithium. Cawte, J. The Australian and New Zealand journal of psychiatry. (1999) [Pubmed]
  21. Ultrastructural aspects of the follicular cells of the pars tuberalis in bats related to the seasonal cycle. Azzali, G., Arcari, M.L., Spaggiari, B., Romita, G. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2003) [Pubmed]
  22. ECT as a form of restraint. Jeffries, J.J., Rakoff, V.M. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1983) [Pubmed]
  23. Determination of paraldehyde by gas chromatography in whole blood from children. Githiga, I.M., Muchohi, S.N., Ogutu, B.R., Newton, C.R., Otieno, G.O., Gitau, E.N., Kokwaro, G.O. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  24. Diuresis during fluid infusion : buffer nerve and spinal influences on it. Suresh, T.P., Sharma, K.N. Indian J. Physiol. Pharmacol. (1979) [Pubmed]
  25. Vascular injury in the neonate associated with intra-arterial injection of paraldehyde. Wait, R.B., Greenhalgh, D., Gamelli, R.L. Clinical pediatrics. (1984) [Pubmed]
  26. Electrolyte changes in plasma and urine during tender coconut water infusion in dogs. Suresh, T.P., Sharma, K.N. Indian J. Physiol. Pharmacol. (1979) [Pubmed]
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