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Chemical Compound Review

Furfuranol     2-furylmethanol

Synonyms: Furfurylcarb, PFFA, Furanmethanol, Furfuralcohol, Furylcarbinol, ...
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Disease relevance of LS-2036

  • The oxidation of furfuryl alcohol to furfural and further to 2-furoic acid by Pseudomonas putida Fu1 was catalyzed by two different dehydrogenases [1].
  • The biological results demonstrated that furfuryl alcohol had neither anti-HIV activity nor cytotoxicity in vitro, suggesting the acid instability of D4-nucleosides is unlikely to have an impact on the toxicity of these nucleoside analogs in humans [2].

High impact information on LS-2036

  • Nafion-polyfurfuryl alcohol nanocomposite membranes with low methanol permeability and high proton conductivity were synthesized by in-situ polymerisation of furfuryl alcohol inside commercial Nafion membranes [3].
  • Acid-labile THP- or TBS-protected alcohol, furfuryl alcohol, and geraniol could be acylated as well as base-labile alcohols [4].
  • By using the convenient protocol for conversion of 2-substituted furans into 4-oxo-2-alkenoic acids ((i) NBS, (ii) NaClO(2)), macrosphelide B (2) was synthesized from furyl alcohol 5 (>98% ee) and acid 6 (99% ee) [5].
  • The FFA was consumed when solutions of PABA, ODPABA, OMC, and OCR were illuminated, but no loss of FFA other than by direct photolysis occurred in solutions of BZ3, BZ8, or OCS [6].
  • Since parts of HMF such as furan, furfuryl alcohol, and 2-furaldehyde did not influence the activities of any enzymes tested, the substituted form of furan with a hyroxymethyl group and a formyl group might be important for the inhibition of pol lambda and TdT [7].

Chemical compound and disease context of LS-2036

  • The conversion of relatively toxic furfural to less toxic furfuryl alcohol suggests a beneficial role for this enzyme in mitigating furfural toxicity encountered during ethanol production from lignocellulosic biomass [8].

Biological context of LS-2036


Anatomical context of LS-2036


Associations of LS-2036 with other chemical compounds


Gene context of LS-2036


Analytical, diagnostic and therapeutic context of LS-2036


  1. Xanthine dehydrogenase and 2-furoyl-coenzyme A dehydrogenase from Pseudomonas putida Fu1: two molybdenum-containing dehydrogenases of novel structural composition. Koenig, K., Andreesen, J.R. J. Bacteriol. (1990) [Pubmed]
  2. 2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions. Shi, J., Ray, A.S., Mathew, J.S., Anderson, K.S., Chu, C.K., Schinazi, R.F. Bioorg. Med. Chem. Lett. (2004) [Pubmed]
  3. Nafion-polyfurfuryl alcohol nanocomposite membranes with low methanol permeation. Liu, J., Wang, H., Cheng, S., Chan, K.Y. Chem. Commun. (Camb.) (2004) [Pubmed]
  4. Highly powerful and practical acylation of alcohols with acid anhydride catalyzed by Bi(OTf)(3). Orita, A., Tanahashi, C., Kakuda, A., Otera, J. J. Org. Chem. (2001) [Pubmed]
  5. Furan ring oxidation strategy for the synthesis of macrosphelides A and B. Kobayashi, Y., Kumar, G.B., Kurachi, T., Acharya, H.P., Yamazaki, T., Kitazume, T. J. Org. Chem. (2001) [Pubmed]
  6. Photochemical formation of singlet molecular oxygen in illuminated aqueous solutions of several commercially available sunscreen active ingredients. Allen, J.M., Gossett, C.J., Allen, S.K. Chem. Res. Toxicol. (1996) [Pubmed]
  7. 5-(Hydroxymethyl)-2-furfural: a selective inhibitor of DNA polymerase lambda and terminal deoxynucleotidyltransferase. Mizushina, Y., Yagita, E., Kuramochi, K., Kuriyama, I., Shimazaki, N., Koiwai, O., Uchiyama, Y., Yomezawa, Y., Sugawara, F., Kobayashi, S., Sakaguchi, K., Yoshida, H. Arch. Biochem. Biophys. (2006) [Pubmed]
  8. Purification and characterization of a furfural reductase (FFR) from Escherichia coli strain LYO1--an enzyme important in the detoxification of furfural during ethanol production. Gutiérrez, T., Ingram, L.O., Preston, J.F. J. Biotechnol. (2006) [Pubmed]
  9. In vitro and occupational induction of sister-chromatid exchanges in human lymphocytes with furfuryl alcohol and furfural. Gomez-Arroyo, S., Souza, V. Mutat. Res. (1985) [Pubmed]
  10. Influence of furfural on anaerobic glycolytic kinetics of Saccharomyces cerevisiae in batch culture. Palmqvist, E., Almeida, J.S., Hahn-Hägerdal, B. Biotechnol. Bioeng. (1999) [Pubmed]
  11. Evidence for the absence of mutagenic activity of furfuryl alcohol in tests of germ cells in Drosophila melanogaster. Rodriguez-Arnaiz, R., Ramos Morales, P., Moctezuma, R.V., Bernal Salas, R.M. Mutat. Res. (1989) [Pubmed]
  12. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Nomeir, A.A., Silveira, D.M., McComish, M.F., Chadwick, M. Drug Metab. Dispos. (1992) [Pubmed]
  13. Photochemical studies on xanthurenic acid . Roberts, J.E., Wishart, J.F., Martinez, L., Chignell, C.F. Photochem. Photobiol. (2000) [Pubmed]
  14. Neurotoxicity of furfuryl alcohol vapor in prolonged inhalation exposure. Savolainen, H., Pfäffli, P. Environmental research. (1983) [Pubmed]
  15. Quantitation of the singlet oxygen produced by UVA irradiation of human lens proteins. Linetsky, M., Ortwerth, B.J. Photochem. Photobiol. (1997) [Pubmed]
  16. Chemosorption sampling and analysis of formaldehyde in air. Influence on recovery during the simultaneous sampling of formaldehyde, phenol, furfural and furfuryl alcohol. Andersson, K., Hallgren, C., Levin, J.O., Nilsson, C.A. Scandinavian journal of work, environment & health. (1981) [Pubmed]
  17. Genomic adaptation of ethanologenic yeast to biomass conversion inhibitors. Liu, Z.L. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  18. Photodegradation and phototoxicity studies of furosemide. Involvement of singlet oxygen in the photoinduced hemolysis and lipid peroxidation. Vargas, F., Martinez Volkmar, I., Sequera, J., Mendez, H., Rojas, J., Fraile, G., Velasquez, M., Medina, R. J. Photochem. Photobiol. B, Biol. (1998) [Pubmed]
  19. Influence of epicatechin reactions on the mechanisms of Maillard product formation in low moisture model systems. Totlani, V.M., Peterson, D.G. J. Agric. Food Chem. (2007) [Pubmed]
  20. Quantum yields and kinetics of the photobleaching of hematoporphyrin, Photofrin II, tetra(4-sulfonatophenyl)-porphine and uroporphyrin. Spikes, J.D. Photochem. Photobiol. (1992) [Pubmed]
  21. Reduction of furfural to furfuryl alcohol by ethanologenic strains of bacteria and its effect on ethanol production from xylose. Gutiérrez, T., Buszko, M.L., Ingram, L.O., Preston, J.F. Appl. Biochem. Biotechnol. (2002) [Pubmed]
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