Disease relevance of butanenitrile

• Using GLC-mass spectrometry, 1-nitrobutane (an N-oxidation product) and butyronitrile (a dehydration product) were identified as metabolites from microsomal incubations of n-BO [1].
• Metabolism of benzonitrile and butyronitrile by Klebsiella pneumoniae [2].

High impact information on butanenitrile

• The title compound exhibits luminescence both at room temperature in acetonitrile fluid solution and at 77 K in butyronitrile rigid matrix [3].
• Gas-phase complex ions containing the vanadyl (VO(2+)), vanadyl hydroxide (VOOH(+)), or vanadium(V) dioxo (VO(2)(+)) cation and nitrile (acetonitrile, propionitrile, butyronitrile, or benzonitrile) ligands were generated by electrospray ionization (ESI) for study by multiple-stage tandem mass spectrometry [4].
• Aliphatic nitriles are the most effective substrates, showing increasing rates of hydrolysis with increasing size of the residues, as demonstrated in the series butyronitrile, octanenitrile, phenylpropionitrile [5].
• No common pattern could be drawn for all the eight nitriles tested in vitro, although there were some similarities between the malformations elicited by propionitrile and n-butyronitrile or between those elicited by the five unsaturated nitriles [6].
• Except for acrylonitrile, butyronitrile and isobutyronitrile metabolism, the ethmoturbinate microsomes had higher activities than the maxilloturbinate microsomes [7].

Chemical compound and disease context of butanenitrile

• 6. The data are consistent with two distinct pathways of metabolism for BOX, (1) reduction to an imine, hydrolysis and subsequent conversion of butyraldehyde to 14CO2 and (2) CYP3A-catalysed dehydration of BOX to butyronitrile followed by CYP2E1-catalysed release of cyanide [8].

Biological context of butanenitrile

• The present results are compared with those of previous studies, and the conclusions support the rationale for administration of inorganic cyanide antagonists to individuals poisoned by inhalation of acetonitrile, propionitrile, or n-butyronitrile [9].

Associations of butanenitrile with other chemical compounds

• We have measured the dynamics of solvation of a triplet state probe, quinoxaline, in the glass-forming dipolar liquid butyronitrile near its glass transition temperature T(g)=95 K [10].

References