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Chemical Compound Review

Butalyde     butanal

Synonyms: Butyral, Butal, Butaldehyde, Butyraldehyd, Butanaldehyde, ...
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Disease relevance of butanal


High impact information on butanal


Biological context of butanal

  • ADH activities measured in the presence of both acetone and butyraldehyde did not exceed activities measured with either substrate present alone, indicating a common active site for both substrates [11].

Anatomical context of butanal


Associations of butanal with other chemical compounds

  • Microgram per m(3) (sub-ppb) levels of the aliphatic aldehydes, propanal, 1-butanal, 1-heptanal, and 1-hexanal, in ambient air were successfully determined by HPLC separation with fluorometric detection [13].
  • With only few exceptions, the animals of both species significantly discriminated concentrations below 1 ppm from the odorless solvent, and with n-butanal and n-hexanal individual pigtail macaques even demonstrated thresholds below 1 ppb [14].
  • This enzyme is responsible for the final conversion of butyraldehyde to butanol, and is distinct from the NADPH-dependent alcohol dehydrogenase (ADH) also present in the organism [15].
  • Column studies demonstrated that transport of particular electron donors varied significantly; ethyl acetate and butyraldehyde were transported more rapidly than butyl acetate and ethanol [16].
  • SKF 525-A not only inhibited the mutagenic activation of DBN by microsomes from rats treated with the inducers but also selectively inhibited the formation of butyraldehyde and butyl alcohols from DBN [17].

Gene context of butanal

  • An FDH/Os-polymer electrode responded linearly over the concentration range of 2 x 10(-6)-5 x 10(-4) M for formaldehyde, while an ADH/Os-polymer electrode, though responding similarly to long chain aldehydes, such as propionaldehyde and butylaldehyde, responded linearly over the concentration range of 4 x 10(-6)-2 x 10(-4) M for acetaldehyde [18].

Analytical, diagnostic and therapeutic context of butanal


  1. High-pressure and stark hole-burning studies of chlorosome antennas from Chlorobium tepidum. Wu, H.M., Rätsep, M., Young, C.S., Jankowiak, R., Blankenship, R.E., Small, G.J. Biophys. J. (2000) [Pubmed]
  2. Cloning and sequencing of the gene encoding an aldehyde dehydrogenase that is induced by growing Alteromonas sp. Strain KE10 in a low concentration of organic nutrients. Maeda, T., Yoshinaga, I., Shiba, T., Murakami, M., Wada, A., Ishida, Y. Appl. Environ. Microbiol. (2000) [Pubmed]
  3. Molecular cloning of an alcohol (butanol) dehydrogenase gene cluster from Clostridium acetobutylicum ATCC 824. Petersen, D.J., Welch, R.W., Rudolph, F.B., Bennett, G.N. J. Bacteriol. (1991) [Pubmed]
  4. Alpha-hydroxylation and mutagenicity of unsymmetrical N-nitrosodialkylamines with a butyl group. Suzuki, E., Mochizuki, M., Takeda, K., Okada, M. Jpn. J. Cancer Res. (1985) [Pubmed]
  5. A novel immunosensor based on immobilization of hepatitis B surface antibody on platinum electrode modified colloidal gold and polyvinyl butyral as matrices via electrochemical impedance spectroscopy. Tang, D., Yuan, R., Chai, Y., Dai, J., Zhong, X., Liu, Y. Bioelectrochemistry (Amsterdam, Netherlands) (2004) [Pubmed]
  6. Reaction pathway of bovine aortic lysyl oxidase. Williamson, P.R., Kagan, H.M. J. Biol. Chem. (1986) [Pubmed]
  7. Identification of the cytochrome P450 isozymes involved in the metabolism of N-nitrosodipropyl-,N-nitrosodibutyl- and N-nitroso-n-butyl-n-propylamine. Shu, L., Hollenberg, P.F. Carcinogenesis (1996) [Pubmed]
  8. Effect of lipid structure on the capacity of myelin basic protein to alter vesicle properties: potent effects of aliphatic aldehydes in promoting basic protein-induced vesicle aggregation. Epand, R.M., Dell, K., Surewicz, W.K., Moscarello, M.A. J. Neurochem. (1984) [Pubmed]
  9. Nicotinamide adenine dinucleotide phosphate-decanaldehyde adduct as an inhibitor of beef brain NADP-linked aldehyde reductase. Towell, J.F., Erwin, V.G., Deitrich, R.A. J. Med. Chem. (1979) [Pubmed]
  10. A study of the pH- and temperature-dependence of the reactions of yeast alcohol dehydrogenase with ethanol, acetaldehyde and butyraldehyde as substrates. Dickenson, C.J., Dickinson, F.M. Biochem. J. (1975) [Pubmed]
  11. Purification and characterization of a primary-secondary alcohol dehydrogenase from two strains of Clostridium beijerinckii. Ismaiel, A.A., Zhu, C.X., Colby, G.D., Chen, J.S. J. Bacteriol. (1993) [Pubmed]
  12. In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats. Kitamura, S., Suzuki, T., Kadota, T., Yoshida, M., Ohashi, K., Ohta, S. Drug Metab. Dispos. (2003) [Pubmed]
  13. Polymer-mediated extraction of the fluorescent compounds derived by Hantzsch reaction with dimedone for the sensitive determination of aliphatic aldehydes in air. Saitoh, T., Suzuki, S., Hiraide, M. Journal of chromatography. A (2006) [Pubmed]
  14. Olfactory sensitivity for aliphatic aldehydes in squirrel monkeys and pigtail macaques. Laska, M., Hofmann, M., Simon, Y. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. (2003) [Pubmed]
  15. Cloning of an NADH-dependent butanol dehydrogenase gene from Clostridium acetobutylicum. Petersen, D.J., Welch, R.W., Walter, K.A., Mermelstein, L.D., Papoutsakis, E.T., Rudolph, F.B., Bennett, G.N. Ann. N. Y. Acad. Sci. (1991) [Pubmed]
  16. In situ bioremediation of nitrate and perchlorate in vadose zone soil for groundwater protection using gaseous electron donor injection technology. Evans, P.J., Trute, M.M. Water Environ. Res. (2006) [Pubmed]
  17. In vitro metabolic activation of N,N-dibutylnitrosamine in mutagenesis. Suzuki, E., Mochizuki, M., Wakabayashi, Y., Okada, M. Gann = Gan. (1983) [Pubmed]
  18. Electroanalytical properties of aldehyde biosensors with a hybrid-membrane composed of an enzyme film and a redox Os-polymer film. Yao, T., Handa, S. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. (2003) [Pubmed]
  19. Ultrasensitive potentiometric immunosensor based on SA and OCA techniques for immobilization of HBsAb with colloidal Au and polyvinyl butyral as matrixes. Yuan, R., Tang, D., Chai, Y., Zhong, X., Liu, Y., Dai, J. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
  20. Unknown bisethylisooctanollactone isomers in industrial waste water. Isolation, identification and occurrence in surface water. Knepper, T.P., Müller, J., Wulff, T., Maes, A. Journal of chromatography. A. (2000) [Pubmed]
  21. Novel potentiometry immunoassay with amplified sensitivity for diphtheria antigen based on Nafion, colloidal Ag and polyvinyl butyral as matrixes. Tang, D., Yuan, R., Chai, Y., Zhang, L., Zhong, X., Dai, J., Liu, Y. J. Biochem. Biophys. Methods (2004) [Pubmed]
  22. Support film in transmission electron microscopy: experiences with polyvinyl butyral Pioloform BM 18. Kneissler, U., Harendza, S., Helmchen, U. Journal of electron microscopy. (2003) [Pubmed]
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