Disease relevance of Isomaltulose

• The extraction and mechanism of a novel isomaltulose-synthesizing enzyme from Erwinia rhapontici [1].
• Isomaltulose synthase from Klebsiella sp. strain LX3: gene cloning and characterization and engineering of thermostability [2].
• The UQ68J SI differed substantially, and it showed the highest isomaltulose-producing efficiency in E. coli cells [3].
• In conclusion, the administration of isomaltulose at dietary levels up to 10% for 13 consecutive weeks was well tolerated without any signs of toxicity [4].
• The dietary level of 10% isomaltulose was equivalent to about 7 g/kg body weight/day [5].

Psychiatry related information on Isomaltulose

• Maximum yield of isomaltulose at 78-80% of supplied sucrose was achieved in less than half the reaction time needed by CBS574.77, and the amount of contaminating trehalulose (4%) was the lowest recorded from an isomaltulose-producing microbe [6].

High impact information on Isomaltulose

• UQ68J SI activity was optimal at pH 5 and 30 to 35 degrees C, and it produced a high ratio of isomaltulose to trehalulose (>22:1) across its pH and temperature ranges for activity (pH 4 to 7 and 20 to 50 degrees C) [3].
• Homology searches of the deduced amino acid sequences revealed that the proteins belong to a cluster of gene products putatively responsible for the metabolism of isomaltulose (palatinose; 6-O-alpha-d-glucopyranosyl-d-fructose) [7].
• The immobilized cells of Klebsiella sp. LX3 convert more than 99% of sucrose to products that consist of more than 87% of isomaltulose, 11.6% of trehalulose, and <1% of glucose [8].
• The potential subchronic oral toxicity of isomaltulose (Palatinose) was examined by administering this substance in the diet to groups of 20 male and 20 female Wistar rats at levels of 0, 2.5, 5 and 10% for 13 consecutive weeks [4].
• In several subchronic toxicity studies, the administration of large doses (up to 7.0 and 8.1 g/kg body weight/day in male and female rats, respectively) of isomaltulose, did not result in adverse effects [9].

Chemical compound and disease context of Isomaltulose

• Enhanced conversion of sucrose to isomaltulose by a mutant of Erwinia rhapontici [10].
• Effect of isomaltulose on acid production and insoluble glucan synthesis by Streptococcus mutans [11].

Biological context of Isomaltulose

• As hydrolysis in the small intestine is complete, even high levels of isomaltulose are well tolerated in animals and humans [9].
• Mutagenesis of Erwinia rhapontici was performed to enhance the production of isomaltulose from sucrose [10].

Anatomical context of Isomaltulose

• In vivo studies with rats and pigs indicate that isomaltulose is completely hydrolyzed and absorbed in the small intestine [9].

Associations of Isomaltulose with other chemical compounds

• The subjects were requested to refrain from all oral hygiene procedures for 3 days and were provided between-meal snacks containing 157 g of 4 test sugars (100% isomaltulose, 70% isomaltulose + 30% sucrose, 50% isomaltulose + 50% sucrose, and 100% sucrose) [12].

References