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Chemical Compound Review

Palatinose     (2R,3S,4S,5R,6S)-2- (hydroxymethyl)-6-[[(2R...

Synonyms: Isomaltulose, CPD-230, SureCN118910, CHEBI:18394, STOCK1N-68373, ...
 
 
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Disease relevance of C01742

 

High impact information on C01742

 

Chemical compound and disease context of C01742

 

Biological context of C01742

 

Anatomical context of C01742

 

Associations of C01742 with other chemical compounds

 

Gene context of C01742

  • We identified a putative pal gene cluster (palR, palE, palF, palG, palK, palA, and palB) in the plant-tumorigenic bacterium Agrobacterium tumefaciens MAFF301001; by sequencing analyses, this cluster was found to be involved in palatinose transport, and its functional importance was revealed by mutational analyses [4].
  • Insertion mutations in the palK and palE genes showed the necessity of these genes for bacterial growth and chemotaxis with palatinose as the carbon source, but no inhibition of tumorigenesis was observed [4].
  • Molecular characterization of the alpha-glucosidase activity in Enterobacter sakazakii reveals the presence of a putative gene cluster for palatinose metabolism [11].
 

Analytical, diagnostic and therapeutic context of C01742

  • Based on our results we conclude that plants can efficiently be used as bioreactors for the production of palatinose [20].
  • 3. Growth and maintenance of rats demonstrated 20--40 percent diminished caloric utilisation of diets containing 34.5 percent hydrogenated palatinose whereas indirect calorimetry in man showed about 50 percent caloric deficit [15].
  • Consequently, repeated ingestion of DFAIII for 12 days was as safe as palatinose ingestion, especially with respect to abdominal symptoms and blood test results, and its high resistance to enterobacterial fermentation in humans was not impaired [21].
  • We investigated the effect of palatinose on mental concentration using the Uchida-Kraepelin psycho diagnostic test [22].
  • The determination of the three-dimensional structure of SmuA will provide a basis for rational protein-engineering studies in order to optimize the industrial production of palatinose [23].

References

  1. Metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. Participation and properties of sucrose-6-phosphate hydrolase and phospho-alpha-glucosidase. Thompson, J., Robrish, S.A., Immel, S., Lichtenthaler, F.W., Hall, B.G., Pikis, A. J. Biol. Chem. (2001) [Pubmed]
  2. Non-cariogenicity of the disaccharide palatinose in experimental dental caries of rats. Ooshima, T., Izumitani, A., Sobue, S., Okahashi, N., Hamada, S. Infect. Immun. (1983) [Pubmed]
  3. Cloning and characterization of the gene cluster for palatinose metabolism from the phytopathogenic bacterium Erwinia rhapontici. Börnke, F., Hajirezaei, M., Sonnewald, U. J. Bacteriol. (2001) [Pubmed]
  4. Structural and functional analysis of a putative gene cluster for palatinose transport on the linear chromosome of Agrobacterium tumefaciens MAFF301001. De Costa, D.M., Suzuki, K., Yoshida, K. J. Bacteriol. (2003) [Pubmed]
  5. Characterization of AGT1 encoding a general alpha-glucoside transporter from Saccharomyces. Han, E.K., Cotty, F., Sottas, C., Jiang, H., Michels, C.A. Mol. Microbiol. (1995) [Pubmed]
  6. Sugar-regulated expression of a putative hexose transport gene in grape. Atanassova, R., Leterrier, M., Gaillard, C., Agasse, A., Sagot, E., Coutos-Thévenot, P., Delrot, S. Plant Physiol. (2003) [Pubmed]
  7. Metabolizable and non-metabolizable sugars activate different signal transduction pathways in tomato. Sinha, A.K., Hofmann, M.G., Römer, U., Köckenberger, W., Elling, L., Roitsch, T. Plant Physiol. (2002) [Pubmed]
  8. The sucrose analog palatinose leads to a stimulation of sucrose degradation and starch synthesis when supplied to discs of growing potato tubers. Fernie, A.R., Roessner, U., Geigenberger, P. Plant Physiol. (2001) [Pubmed]
  9. Potato tubers as bioreactors for palatinose production. Börnke, F., Hajirezaei, M., Sonnewald, U. J. Biotechnol. (2002) [Pubmed]
  10. 13-Week oral toxicity study with isomaltulose (Palatinose) in rats. Jonker, D., Lina, B.A., Kozianowski, G. Food Chem. Toxicol. (2002) [Pubmed]
  11. Molecular characterization of the alpha-glucosidase activity in Enterobacter sakazakii reveals the presence of a putative gene cluster for palatinose metabolism. Lehner, A., Riedel, K., Rattei, T., Ruepp, A., Frishman, D., Breeuwer, P., Diep, B., Eberl, L., Stephan, R. Syst. Appl. Microbiol. (2006) [Pubmed]
  12. Effects of parenteral palatinose on glucose metabolism in normal and streptozotocin diabetic rats. Okuda, Y., Kawai, K., Chiba, Y., Koide, Y., Yamashita, K. Horm. Metab. Res. (1986) [Pubmed]
  13. Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion. Arai, H., Mizuno, A., Matsuo, K., Fukaya, M., Sasaki, H., Arima, H., Matsuura, M., Taketani, Y., Doi, T., Takeda, E. Metab. Clin. Exp. (2004) [Pubmed]
  14. Hydrolysis of alpha-D-glucopyranosyl-1,6-sorbitol and alpha-D-glucopyranosyl-1,6-mannitol by rat intestinal disaccharidases. Goda, T., Takase, S., Hosoya, N. J. Nutr. Sci. Vitaminol. (1988) [Pubmed]
  15. Metabolism of hydrogenated palatinose, an equimolar mixture of alpha-D-glucopyranosido-1,6-sorbitol and alpha-D-glucopyranosido-1,6-mannitol. Grupp, U., Siebert, G. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1978) [Pubmed]
  16. Decreased sucrose content triggers starch breakdown and respiration in stored potato tubers (Solanum tuberosum). Hajirezaei, M.R., Börnke, F., Peisker, M., Takahata, Y., Lerchl, J., Kirakosyan, A., Sonnewald, U. J. Exp. Bot. (2003) [Pubmed]
  17. Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men. Arai, H., Mizuno, A., Sakuma, M., Fukaya, M., Matsuo, K., Muto, K., Sasaki, H., Matsuura, M., Okumura, H., Yamamoto, H., Taketani, Y., Doi, T., Takeda, E. Metab. Clin. Exp. (2007) [Pubmed]
  18. Effects of frequent mouthrinses with palatinose and xylitol on dental plaque. Lingström, P., Lundgren, F., Birkhed, D., Takazoe, I., Frostell, G. Eur. J. Oral Sci. (1997) [Pubmed]
  19. Studies on the intestinal disaccharidases of the pigeon. III. Separation, purification and properties of sucrase-isomaltase and maltase-glucoamylase. Prakash, K., Patil, S.D., Hegde, S.N. Arch. Int. Physiol. Biochim. (1983) [Pubmed]
  20. High-level production of the non-cariogenic sucrose isomer palatinose in transgenic tobacco plants strongly impairs development. Börnke, F., Hajirezaei, M., Heineke, D., Melzer, M., Herbers, K., Sonnewald, U. Planta (2002) [Pubmed]
  21. Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans. Tamura, A., Shiomi, T., Tamaki, N., Shigematsu, N., Tomita, F., Hara, H. Biosci. Biotechnol. Biochem. (2004) [Pubmed]
  22. The effect of palatinose on mental concentration in humans. Kashimura, J., Nagai, Y., Ebashi, T. J. Nutr. Sci. Vitaminol. (2003) [Pubmed]
  23. Overexpression, purification, crystallization and preliminary diffraction studies of the Protaminobacter rubrum sucrose isomerase SmuA. Ravaud, S., Watzlawick, H., Haser, R., Mattes, R., Aghajari, N. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. (2006) [Pubmed]
 
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