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Chemical Compound Review

Dimethoxyphenylethylamine     2-(3,4- dimethoxyphenyl)ethanamine

Synonyms: DIMPEA, DMPEA, PubChem22139, CHEMBL26019, SureCN210639, ...
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High impact information on Dimethoxyphenylethylamine


Biological context of Dimethoxyphenylethylamine


Anatomical context of Dimethoxyphenylethylamine

  • If the compound bis-N, N dimethoxyphenylethylamine (bis-DMPEA) was either added to DMPEA or substituted for it and incubated with inactive blood plasma taken from non-schizophrenics in the incubation step of the test system a marked positive response was elicited [6].

Associations of Dimethoxyphenylethylamine with other chemical compounds

  • The presence of mescaline in other similar Trichocereus species prompted us to reinvestigate this species, which is commercially available in the United States. The nonphenolic alkaloid extracts yielded an abundance of crystalline mescaline hydrochloride (0.82% yield) and a trace of 3,4-dimethoxyphenethylamine (tlc-ms) [7].
  • Administration of 3,4-dimethoxyphenylethylamine, (DMPEA) which has been incubated with blood plasma from unmedicated, acute schizophrenics, to aggregated mice pretreated with the monoamine oxidase inhibitor, phenylisobutylhydrazine, has been shown to produce an amphetamine-like excitatory, lethal response in such mice [6].

Analytical, diagnostic and therapeutic context of Dimethoxyphenylethylamine


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  4. The effect of mescaline, 3, 4-dimethoxyphenethylamine and 2, 5-dimethoxy-4-methylamphetamine on rat plasma prolactin: evidence for serotonergic mediation. Meltzer, H.Y., Fessler, R.G., Simonovic, M., Fang, V.S. Life Sci. (1978) [Pubmed]
  5. Synthesis and distribution kinetics in animals of [alpha-11C] 3,4-dimethoxyphenethylamine. Mestelan, G., Crouzel, C., Comar, D. International journal of nuclear medicine and biology. (1977) [Pubmed]
  6. Projection of an endocoid involved with schizophrenic reaction. Proctor, C.D., Cho, J.B., Nicolls, A.A. Prog. Clin. Biol. Res. (1985) [Pubmed]
  7. Cactus alkaloids. XXXVI. Mescaline and related compounds from Trichocereus peruvianus. Pardanani, J.H., McLaughlin, J.L., Kondrat, R.W., Cooks, R.G. Lloydia. (1977) [Pubmed]
  8. Preliminary preformulation studies of a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new drug development. Morita, M., Hosokami, T., Konno, T., Kinuno, K., Mafune, E., Takasugi, N. Chem. Pharm. Bull. (1995) [Pubmed]
  9. 3,4-Dimethoxyphenylethylamine excretion of normals and schizophrenics, behaviour during total fasting. Knoll, E., Wisser, H., Emrich, H.M. Clin. Chim. Acta (1978) [Pubmed]
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