Disease relevance of triphenyltin

• The ratio DHT+T/DHA, a possible indicator of metabolic androgenization, tended to increase (0.43 versus 0.35, p=0.06) in TPT exposed females [1].
• The present study was designed to assess potential reproductive toxicity caused by fentin and fenbutatin in the mice [2].
• Adult male mice received i.p. injections of fentin hydroxide and fenbutatin oxide at a dose of 0, 10 or 25mug/kg body weight on 1st, 3rd and 5th day of experimentation [2].

High impact information on triphenyltin

• In all cell lines, both TBT and TPT increased levels of hCG secretion and aromatase activity in a dose- and time-dependent fashion following exposure to nontoxic concentration ranges [3].
• Fungicide residues. Part VII. Determination of residues of fentin in vegetables and cocoa products by spectrofluorimetry [4].
• Effects of fentin hydroxide on reproduction of the Japanese quail (Coturnix coturnix japonica) [5].
• Reduction of spermatogenesis and steroidogenesis in mice after fentin and fenbutatin administration [2].
• Injection of three different organotin compounds such as tripalmitin, fentin and fenbutatin produced a significant increase in the hemolymph sugar level of intact crabs at Oziotelphusa senex senex apparently by stimulating release of the hyperglycemic hormone (HGH) [6].

Chemical compound and disease context of triphenyltin

• The results indicated that: (1) the decreasing order of the average acute toxicity to cyanobacteria and green algae of five dissimilar organotins and pyrethroids pesticides was: fentin hydroxide > cyhexatin > azocyclotin > fenbutatin oxide > beta-cyfluthrin [7].

Associations of triphenyltin with other chemical compounds

• The results suggest that fentin and fenbutatin cause impairment of spermatogenesis through the inhibition of testosterone production [2].

References