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Chemical Compound Review:

Gelnique 4-diethylaminobut-2-ynyl 2-cyclohexyl-2...

Synonyms: Dridase, Gelinique, Tropax, Ditropan Xl, Prestwick_621, ...

This record was replaced with 4634.

DeLuca, R.V. et al., Li, L. et al., Van Arendonk, K.J. et al., Dmochowski, R.R., Lubeck, D.P. et al., et al.

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Disease relevance of Oxytrol

Is extended-release oxybutynin (Ditropan XL) or tolterodine (Detrol) more effective in the treatment of an overactive bladder [1]?

Psychiatry related information on Oxytrol

Oxybutynin chloride (Ditropan) in enuresis [2].

High impact information on Oxytrol

Oxybutynin (Ditropan) is widely utilized in treatment of incontinence due to neurogenic bladder dysfunction [3].
STUDY OBJECTIVE: Aerosolized ipratropium bromide or orally administered baclofen or oxybutynin chloride (Ditropan) block methacholine-associated airway hyperreactivity in subjects with chronic cervical spinal cord injury (SCI), whereas these agents do not inhibit airway hyperreactivity associated with the inhalation of histamine [4].
This model is used to model S-oxybutynin's kinetics following an oral administration of Ditropan, and allows the distribution rate to depend on time-dependent covariates blood pressure and heart rate, which are measured with errors [5].

Chemical compound and disease context of Oxytrol

METHODS: The U-IIQ and the U-UDI were incorporated in a single arm study of an investigational once-a-day formulation of oxybutynin (Ditropan XL) for urge incontinence [6].
Sepracor is developing (S)-oxybutynin, a single-isomer version of Alza's Ditropan (racemic oxybutynin), a muscarinic acetylcholine receptor antagonist, as a potential treatment for urinary incontinence [7].

Analytical, diagnostic and therapeutic context of Oxytrol

Significant increases in voided volume (38% versus 53%; P <0.01) and total bladder capacity (55% versus 70%; P = 0.03), normalized for age-expected bladder capacity, occurred by the first clinic visit after beginning Ditropan XL [8].

References

Is extended-release oxybutynin (Ditropan XL) or tolterodine (Detrol) more effective in the treatment of an overactive bladder? Hartnett, N.M., Saver, B.G. The Journal of family practice. (2001) [Pubmed]
Oxybutynin chloride (Ditropan) in enuresis. Buttarazzi, P.J. J. Urol. (1977) [Pubmed]
R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine. Kachur, J.F., Peterson, J.S., Carter, J.P., Rzeszotarski, W.J., Hanson, R.C., Noronha-Blob, L. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
Effects of a beta2-agonist on airway hyperreactivity in subjects with cervical spinal cord injury. DeLuca, R.V., Grimm, D.R., Lesser, M., Bauman, W.A., Almenoff, P.L. Chest (1999) [Pubmed]
A population pharmacokinetic model with time-dependent covariates measured with errors. Li, L., Lin, X., Brown, M.B., Gupta, S., Lee, K.H. Biometrics (2004) [Pubmed]
A health related quality of life measure for use in patients with urge urinary incontinence: a validation study. Lubeck, D.P., Prebil, L.A., Peeples, P., Brown, J.S. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (1999) [Pubmed]
(S)-oxybutynin (Sepracor). Dmochowski, R.R. Current opinion in investigational drugs (London, England : 2000) (2002) [Pubmed]
Improved efficacy of extended release oxybutynin in children with persistent daytime urinary incontinence converted from regular oxybutynin. Van Arendonk, K.J., Knudson, M.J., Austin, J.C., Cooper, C.S. Urology (2006) [Pubmed]

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