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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Enuresis


Psychiatry related information on Enuresis


High impact information on Enuresis


Chemical compound and disease context of Enuresis


Biological context of Enuresis


Anatomical context of Enuresis


Gene context of Enuresis

  • This study clearly demonstrates that urinary calcium levels modulate AQP2 excretion and is likely to be useful for treatment of children with enuresis [26].
  • The polyuria and urinary concentrating defects associated with an abnormal nightly-increase in AVP in patients with nocturnal enuresis may partly be due to a lack of vasopressin-mediated AQP2 expression since treatment with desmopressin in these patients have normalised their nocturnal urine production [27].
  • This effect was attributed primarily to the reduction of amplitude inhibition following the 120-ms prestimulation interval regardless of whether or not enuresis was associated with ADHD [28].
  • MATERIALS AND METHODS: Urine was collected for 24-hour periods from 44 children with monosymptomatic nocturnal enuresis, 10 children with other forms of enuresis/incontinence (nonmonosymptomatic nocturnal enuresis) and 25 controls, and its aMT6s concentration was estimated using a commercially available radioimmunoassay [29].
  • Adult onset nocturnal enuresis [30].

Analytical, diagnostic and therapeutic context of Enuresis

  • The prostaglandin synthesis inhibitor indomethacin (used as a suppository) was compared to placebo in the treatment of primary nocturnal enuresis in a double-blind crossover study [31].
  • MATERIALS AND METHODS: A multicenter study was done comparing oral dosages (200 and 400 micrograms.) of desmopressin (4-week, randomized, double-blind phase followed by 12 weeks of open label treatment with 400 micrograms.) to 20 micrograms. nasal spray in 66 adults and adolescents 12 to 45 years old with primary nocturnal enuresis [32].
  • The effectiveness of oxybutynin in the treatment of primary enuresis was evaluated in a double-blind study [33].
  • We conclude from this preliminary retrospective study that a high rate of success may be predicted when desmopressin is used in patients with familial nocturnal enuresis, whereas less optimism is warranted when no family history of nocturnal enuresis can be elicited [34].
  • SETTING: West-Mine Region in the Netherlands. SUBJECTS AND METHODS: Prospective cohort study involving 66 of the 80 bedwetting children from all 1652 children born in 1983 in this region [35].


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  2. A pharmacological paradigm for urinary incontinence and enuresis. Ambrosini, P.J. Journal of clinical psychopharmacology. (1984) [Pubmed]
  3. Desmopressin associated symptomatic hyponatremic hypervolemia in children. Are there predictive factors? Thumfart, J., Roehr, C.C., Kapelari, K., Querfeld, U., Eggert, P., Müller, D. J. Urol. (2005) [Pubmed]
  4. Efficacy and toxicity of D-penicillamine in low-level lead poisoning. Shannon, M., Graef, J., Lovejoy, F.H. J. Pediatr. (1988) [Pubmed]
  5. Desmopressin for nocturnal incontinence in the spina bifida population. Horowitz, M., Combs, A.J., Gerdes, D. J. Urol. (1997) [Pubmed]
  6. Attention deficit/hyperactivity disorder in children with nocturnal enuresis. Baeyens, D., Roeyers, H., Hoebeke, P., Verté, S., Van Hoecke, E., Walle, J.V. J. Urol. (2004) [Pubmed]
  7. The effect of desmopressin on short-term memory in children with primary nocturnal enuresis. Müller, D., Florkowski, H., Chavez-Kattau, K., Carlsson, G., Eggert, P. J. Urol. (2001) [Pubmed]
  8. The enuretic child. Bindelglas, P.M. The Journal of family practice. (1975) [Pubmed]
  9. Hyponatremia in patients with nocturnal enuresis treated with DDAVP. Robson, W.L., Nørgaard, J.P., Leung, A.K. Eur. J. Pediatr. (1996) [Pubmed]
  10. Behavioural problems and attention-deficit hyperactivity disorder in children with enuresis: a literature review. Baeyens, D., Roeyers, H., Vande Walle, J., Hoebeke, P. Eur. J. Pediatr. (2005) [Pubmed]
  11. Assignment of dominant inherited nocturnal enuresis (ENUR1) to chromosome 13q. Eiberg, H., Berendt, I., Mohr, J. Nat. Genet. (1995) [Pubmed]
  12. Magical thinking and imipramine poisoning in two school-age children. Herson, V.C., Schmitt, B.D., Rumack, B.H. JAMA (1979) [Pubmed]
  13. Urapidil and enuresis. Karim, S., Zubair, M. Lancet (1992) [Pubmed]
  14. Nocturnal enuresis associated with sodium valproate. Panayiotopoulos, C.P. Lancet (1985) [Pubmed]
  15. Comparative effects of methylphenidate and thioridazine in hyperkinetic children. I. Clinical results. Gittelman-Klein, R., Klein, D.F., Katz, S., Saraf, K., Pollack, E. Arch. Gen. Psychiatry (1976) [Pubmed]
  16. Pimozide-induced enuresis. Shapiro, A.K. The American journal of psychiatry. (1981) [Pubmed]
  17. Preliminary report: amantadine hydrochloride in childhood enuresis. Ambrosini, P.J., Fried, J. Journal of clinical psychopharmacology. (1984) [Pubmed]
  18. Treatment of coexistent night-terrors and somnambulism in adults with imipramine and diazepam. Cooper, A.J. The Journal of clinical psychiatry. (1987) [Pubmed]
  19. The genetics of enuresis: a review. von Gontard, A., Schaumburg, H., Hollmann, E., Eiberg, H., Rittig, S. J. Urol. (2001) [Pubmed]
  20. A pharmacodynamic study of desmopressin in patients with nocturnal enuresis. Nørgaard, J.P., Jønler, M., Rittig, S., Djurhuus, J.C. J. Urol. (1995) [Pubmed]
  21. The aquaporin-2 water channel in autosomal dominant primary nocturnal enuresis. Deen, P.M., Dahl, N., Caplan, M.J. J. Urol. (2002) [Pubmed]
  22. Comparison of urodynamic findings and response to oxybutynin in nocturnal enuresis. Persson-Jünemann, C., Seemann, O., Köhrmann, K.U., Jünemann, K.P., Alken, P. Eur. Urol. (1993) [Pubmed]
  23. Prospective randomized trial using laser acupuncture versus desmopressin in the treatment of nocturnal enuresis. Radmayr, C., Schlager, A., Studen, M., Bartsch, G. Eur. Urol. (2001) [Pubmed]
  24. Platelet plasma membrane in subjects with primary nocturnal enuresis: effect of desmopressin. Giorgi, P.L., Fiorini, R., Biraghi, M., Kantar, A. Biol. Cell (1996) [Pubmed]
  25. Investigation of dysfunctional voiding in children with urgency frequency syndrome and urinary incontinence. Kuo, H.C., Liu, H.T. Urologia internationalis. (2006) [Pubmed]
  26. Low-calcium diet in hypercalciuric enuretic children restores AQP2 excretion and improves clinical symptoms. Valenti, G., Laera, A., Gouraud, S., Pace, G., Aceto, G., Penza, R., Selvaggi, F.P., Svelto, M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  27. Do aquaporins have a role in nocturnal enuresis? Frøkiaer, J., Nielsen, S. Scandinavian journal of urology and nephrology. Supplementum. (1997) [Pubmed]
  28. Prestimulation-induced startle modulation in attention-deficit hyperactivity disorder and nocturnal enuresis. Ornitz, E.M., Hanna, G.L., de Traversay, J. Psychophysiology. (1992) [Pubmed]
  29. Melatonin production is similar in children with monosymptomatic nocturnal enuresis or other forms of enuresis/incontinence and in controls. Kirchlechner, V., Hoffmann-Ehrhart, B., Kovacs, J., Waldhauser, F. J. Urol. (2001) [Pubmed]
  30. Adult onset nocturnal enuresis. Sakamoto, K., Blaivas, J.G. J. Urol. (2001) [Pubmed]
  31. Indomethacin suppository to treat primary nocturnal enuresis: double-blind study. al-Waili, N.S. J. Urol. (1989) [Pubmed]
  32. Oral desmopressin as a new treatment modality for primary nocturnal enuresis in adolescents and adults: a double-blind, randomized, multicenter study. Dutch Enuresis Study Group. Janknegt, R.A., Zweers, H.M., Delaere, K.P., Kloet, A.G., Khoe, S.G., Arendsen, H.J. J. Urol. (1997) [Pubmed]
  33. Oxybutynin efficacy in the treatment of primary enuresis. Lovering, J.S., Tallett, S.E., McKendry, J.B. Pediatrics (1988) [Pubmed]
  34. The role of family history in predicting response to desmopressin in nocturnal enuresis. Hogg, R.J., Husmann, D. J. Urol. (1993) [Pubmed]
  35. Bedwetting and behavioural and/or emotional problems. Hirasing, R.A., van Leerdam, F.J., Bolk-Bennink, L.B., Bosch, J.D. Acta Paediatr. (1997) [Pubmed]
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