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Chemical Compound Review

SureCN852513     ethyl 3-phenylprop-2-ynoate

Synonyms: CCRIS 4504, E45309_ALDRICH, AG-E-62187, ACMC-209ft8, ANW-24762, ...
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Disease relevance of Ethylphenylpropiolate


High impact information on Ethylphenylpropiolate


Chemical compound and disease context of Ethylphenylpropiolate


Biological context of Ethylphenylpropiolate


Anatomical context of Ethylphenylpropiolate

  • Hyperplasiogenic agents such as mezerein and ethylphenylpropiolate were also effective in causing a reduction in the level of epidermal cytosol GC receptor level, but weak tumor promoters such as phorbol dibenzoate and 4-O-methyl TPA were less effective than TPA [13].

Gene context of Ethylphenylpropiolate

  • Multiple treatments with TPA or ethyl phenylpropiolate resulted in a sustained elevation of XO activity which peaked at five treatments and then declined [3].

Analytical, diagnostic and therapeutic context of Ethylphenylpropiolate

  • Two-dimensional gel electrophoresis was used to compare the changes in mouse epidermal proteins induced by the potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), by the moderate promoter mechanical abrasion, and by the weakly promoting hyperplasiogenic agents mezerein and ethylphenylpropiolate [14].


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  2. Anti-inflammatory glycoterpenoids from Scrophularia auriculata. Giner, R.M., Villalba, M.L., Recio, M.C., Máñez, S., Cerdá-Nicolás, M., Ríos, J. Eur. J. Pharmacol. (2000) [Pubmed]
  3. Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters. Pence, B.C., Reiners, J.J. Cancer Res. (1987) [Pubmed]
  4. Tumor promoter-induced refractory state against ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis. Takigawa, M., Simsiman, R.C., Boutwell, R.K. Cancer Res. (1986) [Pubmed]
  5. Tumor promoter actions on rat embryonic development in culture. Huber, B.E., Brown, N.A. Cancer Res. (1983) [Pubmed]
  6. Induction of ornithine decarboxylase in specific subpopulations of murine epidermal cells following multiple exposures to 12-O-tetradecanoylphorbol-13-acetate, mezerein and ethyl phenylpropriolate. Gilmour, S.K., Robertson, F.M., Megosh, L., O'Connell, S.M., Mitchell, J., O'Brien, T.G. Carcinogenesis (1992) [Pubmed]
  7. Comparative histomorphometric changes in SENCAR mouse epidermis in response to multiple treatments with complete and stage-specific tumor promoting agents. Baxter, C.S., Andringa, A., Chalfin, K., Miller, M.L. Carcinogenesis (1989) [Pubmed]
  8. In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acids. Giner, E.M., Máñez, S., Recio, M.C., Giner, R.M., Cerdá-Nicolás, M., Ríos, J.L. Planta Med. (2000) [Pubmed]
  9. Pharmacologically active phenylpropanoids from Senra incana. Farah, M.H., Samuelsson, G. Planta Med. (1992) [Pubmed]
  10. Non-phenolic linear diarylheptanoids from Curcuma xanthorrhiza: a novel type of topical anti-inflammatory agents: structure-activity relationship. Claeson, P., Pongprayoon, U., Sematong, T., Tuchinada, P., Reutrakul, V., Soontornsaratune, P., Taylor, W.C. Planta Med. (1996) [Pubmed]
  11. Anti-inflammatory activity of methanolic extracts from Ventilago harmandiana Pierre. Panthong, A., Kanjanapothi, D., Taesotikul, T., Phankummoon, A., Panthong, K., Reutrakul, V. Journal of ethnopharmacology. (2004) [Pubmed]
  12. Effect of tumor promoters on lipid peroxidation in mouse skin. Logani, M.K., Solanki, V., Slaga, T.J. Carcinogenesis (1982) [Pubmed]
  13. Effects of phorbol ester tumor promoters and hyperplasiogenic agents on cytoplasmic glucocorticoid receptors in epidermis. Davidson, K.A., Slaga, T.J. J. Invest. Dermatol. (1982) [Pubmed]
  14. Protein modifications induced in mouse epidermis by potent and weak tumor-promoting hyperplasiogenic agents. Nelson, K.G., Stephenson, K.B., Slaga, T.J. Cancer Res. (1982) [Pubmed]
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