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Chemical Compound Review

Fluazifop     2-[4-[5- (trifluoromethyl)pyridin-2...

Synonyms: SureCN67403, CHEMBL376218, PS1205_SUPELCO, AG-G-69620, AC1L3MMD, ...
 
 
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Disease relevance of Fluazifop

 

High impact information on Fluazifop

  • Results from four different types of experiment show that this inhibition is due to an action of fluazifop on acetyl-CoA carboxylase and not on fatty acid synthetase [2].
  • Fluazifop-butyl was hydrolysed to fluazifop by rat liver (Vmax mumol/min/g microsomes 6.2 +/- 0.4; cytosol 6.84 +/- 0.85), lung (Vmax microsomes 0.38 +/- 0.1; cytosol 1.5 +/- 0.32) and skin (Vmax microsomes 0.02 +/- 0.0015; cytosol 0.4 +/- 0.06) and by plasma (Vmax mumol/min/mL 5.8 +/- 0.48) and red blood cells (Vmax 0.03 +/- 0.015) [3].
  • Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop [1].
  • In contrast to other PPs fluazifop induced low rate of rcplicative DNA synthesis and did not affect mitoses (M-phase) [1].
  • 5. When six volunteers were given a daily dermal dose of the 0.5% formulation for five consecutive days, the plasma and urinary excretion kinetics of fluazifop could be accurately predicted by simple mathematical extrapolation of the kinetic data from the single exposure study at the equivalent daily dose [4].
 

Biological context of Fluazifop

 

Anatomical context of Fluazifop

  • The aim of this study was to determine the effect of herbicide fluazifop, on the early occurring changes in rat liver regarded as hepatic markers of peroxisome proliferators (PPs) [1].
 

Gene context of Fluazifop

  • 2. Urinary excretion rate of the principal metabolite fluazifop, following dosing with the 5% formulation, was described by a two-compartment pharmacokinetic model; the average elimination half-lives of initial and terminal phases were 18 h and approximately 70 h, respectively [4].
 

Analytical, diagnostic and therapeutic context of Fluazifop

  • Separation of the enantiomers of fluazifop and other 2-phenoxypropionic acids using chiral metal chelate additives in reversed-phase high-performance liquid chromatography [6].

References

  1. Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop. Kostka, G., Palut, D., Ludwicki, J.K., Kopeć-Szlezak, J., Wiadrowska, B., Lembowicz, K. Toxicology (2002) [Pubmed]
  2. Fluazifop, a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species. Walker, K.A., Ridley, S.M., Lewis, T., Harwood, J.L. Biochem. J. (1988) [Pubmed]
  3. Nature and role of xenobiotic metabolizing esterases in rat liver, lung, skin and blood. McCracken, N.W., Blain, P.G., Williams, F.M. Biochem. Pharmacol. (1993) [Pubmed]
  4. Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing. Ramsey, J.D., Woollen, B.H., Auton, T.R., Batten, P.L., Leeser, J.E. Human & experimental toxicology. (1992) [Pubmed]
  5. Determination of fluazifop-butyl and fluazifop acid in soybeans and soybean oil using liquid chromatography with oxidative amperometric detection. Worobey, B.L., Shields, J.B. Journal - Association of Official Analytical Chemists. (1989) [Pubmed]
  6. Separation of the enantiomers of fluazifop and other 2-phenoxypropionic acids using chiral metal chelate additives in reversed-phase high-performance liquid chromatography. Davy, G.S., Francis, P.D. J. Chromatogr. (1987) [Pubmed]
 
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