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Chemical Compound Review

Fusilade     butyl2-[4-[5- (trifluoromethyl)pyridin-2...

Synonyms: Halokon, Onecide, Fusilade 4E, Onecide EC, SureCN54222, ...
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Disease relevance of SL-236


High impact information on SL-236


Chemical compound and disease context of SL-236

  • In order to determine the combined toxicity of the three herbicides, the medium concentration of Maloran 50 WP and three different concentrations of Flubalex of Fusilade S each were administered simultaneously at a final volume of 0.1 ml per egg, at similar times [7].

Anatomical context of SL-236


Associations of SL-236 with other chemical compounds


Analytical, diagnostic and therapeutic context of SL-236

  • Model predictions of the rate and extent of dermal absorption of fluazifop-butyl are compared with the results of dermal absorption studies in human volunteers [6].
  • 1. The absorption of the herbicide fluazifop-butyl (f-b), has been determined from plasma and urine measurements in groups of six male volunteers following dermal administration of 2.5, 25 and 250 micrograms cm-2 from standardized formulations containing 0.05, 0.5 and 5.0% (w/v) fluazifop-butyl to a skin area of 800 cm2 [13].


  1. Oral pharmacokinetics of fluazifop-butyl in human volunteers. Woollen, B.H., Hart, T.B., Batten, P.L., Laird, W.J., Davies, D.S., Dollery, C.T. Human & experimental toxicology. (1991) [Pubmed]
  2. Embryonic toxicity of insecticide Sumithion 50 EC and herbicide Fusilade S in pheasants after individual or combined administration. Varga, T., Hlubik, I., Várnagy, L., Budai, P., Molnár, E. Acta Vet. Hung. (1999) [Pubmed]
  3. Vehicle effects on in vitro percutaneous absorption through rat and human skin. Hilton, J., Woollen, B.H., Scott, R.C., Auton, T.R., Trebilcock, K.L., Wilks, M.F. Pharm. Res. (1994) [Pubmed]
  4. Comparison of two methods for determining the toxicokinetics of fluazifop-butyl after intravenous dosing in rats. Rawlings, J.M., Provan, W.M., Wilks, M.F., Batten, P.L. Human & experimental toxicology. (1994) [Pubmed]
  5. Fate of fluazifop butyl in rat and human skin in vitro. Clark, N.W., Scott, R.C., Blain, P.G., Williams, F.M. Arch. Toxicol. (1993) [Pubmed]
  6. Modelling dermal pharmacokinetics using in vitro data. Part II. Fluazifop-butyl in man. Auton, T.R., Ramsey, J.D., Woollen, B.H. Human & experimental toxicology. (1993) [Pubmed]
  7. Toxicity of the herbicides Flubalex, Fusilade S and Maloran 50 WP to chicken embryos after administration as single compounds or in combination. Várnagy, L., Varga, T., Hlubik, I., Budai, P., Molnár, E. Acta Vet. Hung. (1996) [Pubmed]
  8. Modelling dermal pharmacokinetics using in vitro data. Part I. Fluazifop-butyl in the rat. Auton, T.R., Ramsey, J.D., Woollen, B.H. Human & experimental toxicology. (1993) [Pubmed]
  9. Effect of diphenyl ether herbicides and oxadiazon on porphyrin biosynthesis in mouse liver, rat primary hepatocyte culture and HepG2 cells. Krijt, J., van Holsteijn, I., Hassing, I., Vokurka, M., Blaauboer, B.J. Arch. Toxicol. (1993) [Pubmed]
  10. Histological examination of CAM treated with irritative pesticides. Budai, P., Fáncsi, T., Várnagy, L. Cent. Eur. J. Public Health (2000) [Pubmed]
  11. Pig ear skin as an in-vitro model for human skin permeability. Dick, I.P., Scott, R.C. J. Pharm. Pharmacol. (1992) [Pubmed]
  12. Determination of fluazifop-butyl and fluazifop acid in soybeans and soybean oil using liquid chromatography with oxidative amperometric detection. Worobey, B.L., Shields, J.B. Journal - Association of Official Analytical Chemists. (1989) [Pubmed]
  13. Pharmacokinetics of fluazifop-butyl in human volunteers. II: Dermal dosing. Ramsey, J.D., Woollen, B.H., Auton, T.R., Batten, P.L., Leeser, J.E. Human & experimental toxicology. (1992) [Pubmed]
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