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Chemical Compound Review:

AGN-PC-00IO1Q 5-methyl-3a,4,7,7a- tetrahydroisobenzofuran...

Synonyms: ACMC-1C859, AG-F-16347, AG-F-82904, ANW-27817, NSC-52669, ...

Kanerva, L. et al., Jönsson, B.A. et al., Lindh, C.H. et al., Tarvainen, K. et al., Yokota, K. et al., et al.

Yokota, Johyama, Kunitani, Michitsuji, Yamada,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC52669

Another type of ER hardeners are the phthalic anhydrides, such as methylhexahydrophthalic anhydride (MHHPA) and methyltetrahydrophthalic anhydride (MTHPA), which have been reported as causing immunologically-mediated respiratory diseases and contact urticaria, but not allergic contact dermatitis [1].
Exposure-response relationships in rhinitis and conjunctivitis caused by methyltetrahydrophthalic anhydride [2].

High impact information on NSC52669

Anaphylactic bronchoconstriction in immunized guinea pigs provoked by inhalation and intravenous administration of hexahydrophthalic anhydride and methyltetrahydrophthalic anhydride [3].
Lysine adducts between methyltetrahydrophthalic anhydride and collagen in guinea pig lung [4].
The formation of adducts between methyltetrahydrophthalic anhydride (MTHPA), an important industrial chemical and potent allergen, and collagen from guinea pig lung tissue was investigated [4].
OBJECTIVES: Occupational exposure to methyltetrahydrophthalic anhydride (MTHPA) from an epoxy resin was studied to evaluate the nature of reported ocular and nasal complaints and some risk factors for sensitization [5].
Both patients' immediate allergy to MTHPA and MHHPA was verified by positive prick tests to MTHPA and MHHPA, conjugated with human serum albumin (HSA), and positive radioallergosorbent tests (RASTs) to these anhydrides [6].

Biological context of NSC52669

The investigated MTHP acid was obtained by hydrolysis of a commercial MTHPA mixture, composed of three major isomers [7].
Analysis of urine from a worker exposed to MTHPA makes it reasonable to assume that the method may be used for biological monitoring of MTHPA exposure [7].

Associations of NSC52669 with other chemical compounds

Methyltetrahydrophthalic acid in urine as an indicator of occupational exposure to methyltetrahydrophthalic anhydride [8].

Gene context of NSC52669

The relationship of atopy, smoking, and sensitization to methyltetrahydrophthalic anhydride [9].

Analytical, diagnostic and therapeutic context of NSC52669

Determination of methyltetrahydrophthalic anhydride in air using gas chromatography with electron-capture detection [10].

References

Delayed and immediate allergy caused by methylhexahydrophthalic anhydride. Kanerva, L., Hyry, H., Jolanki, R., Hytönen, M., Estlander, T. Contact Derm. (1997) [Pubmed]
Exposure-response relationships in rhinitis and conjunctivitis caused by methyltetrahydrophthalic anhydride. Yokota, K., Johyama, Y., Yamaguchi, K., Takeshita, T., Morimoto, K. International archives of occupational and environmental health. (1999) [Pubmed]
Anaphylactic bronchoconstriction in immunized guinea pigs provoked by inhalation and intravenous administration of hexahydrophthalic anhydride and methyltetrahydrophthalic anhydride. Zhao, H., Zhang, X.D., Welinder, H., Jonson, B. Allergy (1997) [Pubmed]
Lysine adducts between methyltetrahydrophthalic anhydride and collagen in guinea pig lung. Jönsson, B.A., Wishnok, J.S., Skipper, P.L., Stillwell, W.G., Tannenbaum, S.R. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
Specific antibodies against methyltetrahydrophthalic anhydride and risk factors for sensitization in occupationally exposed subjects. Yokota, K., Johyama, Y., Yamaguchi, K., Fujiki, Y., Takeshita, T., Morimoto, K. Scandinavian journal of work, environment & health. (1997) [Pubmed]
Immunologic contact urticaria due to airborne methylhexahydrophthalic and methyltetrahydrophthalic anhydrides. Tarvainen, K., Jolanki, R., Estlander, T., Tupasela, O., Pfäffli, P., Kanerva, L. Contact Derm. (1995) [Pubmed]
Method for analysis of methyltetrahydrophthalic acid in urine using gas chromatography and selected ion monitoring. Lindh, C.H., Jönsson, B.A. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
Methyltetrahydrophthalic acid in urine as an indicator of occupational exposure to methyltetrahydrophthalic anhydride. Yokota, K., Johyama, Y., Kunitani, Y., Michitsuji, H., Yamada, S. International archives of occupational and environmental health. (2005) [Pubmed]
The relationship of atopy, smoking, and sensitization to methyltetrahydrophthalic anhydride. Yokota, K., Johyama, J., Yamaguchi, K., Takeshita, T., Morimoto, K. International journal of immunopathology and pharmacology. (2004) [Pubmed]
Determination of methyltetrahydrophthalic anhydride in air using gas chromatography with electron-capture detection. Johyama, Y., Yokota, K., Fujiki, Y., Takeshita, T., Morimoto, K. Industrial health. (1999) [Pubmed]

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